2023
Mobile zinc as a modulator of sensory perception. Jacob M. Goldberg and Stephen J. Lippard, FEBS Lett., 597, 151-165 (2023).
2020
Aneuploidy increases resistance to chemotherapeutics by antagonizing cell division. John Michael Replogle, Wen Zhou, Adrianna E. Amaro, James M. McFarland, Mariana Villalobos-Ortiz, Jeremy Ryan, Anthon Letai, Ömer H. Yilmaz, Jason Sheltzer, Stephen J. Lippard, Uri Ben-David, and Angelika Amon, Proc. Nat. Acad. Sci. U. S. A., 117, 30566-30576 (2020).
Enhancing chemotherapy response through augmented synthetic lethality by co-targeting nucleotide excision repair and cell-cycle checkpoints. Yi Wen Kong, Erik C. Dreaden, Sandra Morandell, Wen Zhou, Sanjeev S. Dhara, Ganapathy Sriram, Fred C. Lam, Jesse C. Patterson, Mohiuddin Quadir, Anh Dinh, Kevin E. Shopsowitz, Shohreh Varmeh, Ömer H. Yilmaz, Stephen J. Lippard, H. Christian Reinhardt, Michael T. Hemann, Paula T. Hammond, and Michael B. Yaffe, Nat. Commun., 11:4124 (2020).
A Platinum(IV) Prodrug-Perfluoroaryl Macrocyclic Peptide Conjugate Enhances Platinum Uptake in the Brain. Colin M. Fadzen, Justin M. Wolfe, Wen Zhou, Choi-Fong Cho, Niklas von Spreckelsen, Kathryn T. Hutchinson, Yen-Chun Lee, E. Antonio Chiocca, Sean E. Lawler, Ömer H. Yilmaz, Stephen J. Lippard, and Bradley L. Pentelute, J. Med. Chem., 63, 6741-6747 (2020).
Native Zinc Catalyzes Selective and Traceless Release of Small Molecules in β-Cells. Miseon Lee, Basudeb Maji, Debasish Manna, Sevim Kahraman, Ruth M. Elgamal, Jonnell Small, Praveen Kokkonda, Amedeo Vetere, Jacob M. Goldberg, Stephen J. Lippard, Rohit N. Kulkarni, Bridget K. Wagner, and Amit Choudhary, J. Am. Chem. Soc., 142, 6477-6482 (2020).
HaloTag-Based Hybrid Targetable and Ratiometric Sensors for Intracellular Zinc. Melissa L. Zastrow, Zhen Huang, and Stephen J. Lippard, ACS Chem. Biol., 15, 396-406 (2020).
2019
Sensing intracellular calcium ions using a manganese-based MRI contrast agent. Ali Barandov, Benjamin B. Bartelle, Catherine G. Williamson, Emily S. Loucks, Stephen J. Lippard, and Alan Jasanoff, Nat. Commun., 10:897 (2019).
DNA Intercalation Facilitates Efficient DNA-Targeted Covalent Binding of Phenanthriplatin. Ali A. Almaqwashi, Wen Zhou, M. Nabuan Naufer, Imogen A. Riddell, Ömer H. Yilmaz, Stephen J. Lippard, and Mark C. Williams, J. Am. Chem. Soc., 141, 1537-1545 (2019).
2018
A Sensitive, Nonradioactive Assay for Zn(II) Uptake into Metazoan Cells. Christopher E. R. Richardson, Elizabeth M. Nolan, Matthew D. Shoulders, and Stephen J. Lippard, Biochemistry, 57, 6807-6815 (2018).
Superiority of SpiroZin2 Versus FluoZin-3 for monitoring vesicular Zn2+ allows tracking of lysosomal Zn2+ pools. Yu Han, Jacob M. Goldberg, Stephen J. Lippard, and Amy E. Palmer, Sci. Rep., 8:15034 (2018).
Glutathione-Scavenging Poly(disulfide amide) Nanoparticles for the Effective Delivery of Pt(IV) Prodrugs and Reversal of Cisplatin Resistance. Xiang Ling, Xing Chen, Imogen A. Riddell, Wei Tao, Junqing Wang, Geoffrey Hollett, Stephen J. Lippard, Omid C. Farokhzad, Jinjun Shi, and Jun Wu, Nano Lett., 18, 4618-4625 (2018).
New Tools Uncover New Functions for Mobile Zinc in the Brain. Jacob M. Goldberg and Stephen J. Lippard, Biochemistry, 57, 3991-3992, (2018).
Interaction of the New Monofunctional Anticancer Agent Phenanthriplatin With Transporters for Organic Cations. Anna Hucke, Ga Young Park, Oliver B. Bauer, Georg Beyer, Christina Köppen, Dorothea Zeeh, Christoph A. Wehe, Michael Sperling, Rita Schröter, Marta Kantauskaite, Yohannes Hagos, Uwe Karst, Stephen J. Lippard, and Giuliano Ciarimboli, Front. Chem., 6:180 (2018).
Speciation of Phenanthriplatin and Its Analogs in the Core of Tobacco Mosaic Virus. Amit A. Vernekar, Gilles Berger, Anna E. Czapar, Frank A. Veliz, David I. Wang, Nicole F. Steinmetz, and Stephen J. Lippard, J. Am. Chem. Soc., 140, 4279-4287 (2018).
Cisplatin and Oxaliplatin: Our Current Understanding of Their Actions. Imogen A. Riddell and Stephen J. Lippard, In: Metallo-Drugs: Development and Action of Anticancer Agents. Metal Ions in Life Sciences, Astrid Sigel, Helmut Sigel, Eva Freisinger, Roland K. O. Sigel, Eds., de Gruyter: Berlin, 18, 1-42 (2018).
The effect of geometric isomerism on the anticancer activity of the monofunctional platinum complex trans-[Pt(NH3)2(phenanthridine)Cl]NO3. Wen Zhou, Mohammad Almeqdadi, Michael E. Xifaras, Imogen A. Riddell, Ömer H. Yilmaz, and Stephen J. Lippard, Chem. Commun., 54, 2788-2791 (2018).
A Method for Selective Depletion of Zn(II) Ions from Complex Biological Media and Evaluation of Cellular Consequences of Zn(II) Deficiency. Christopher E. R. Richardson, Lisa S. Cunden, Vincent L. Butty, Elizabeth M. Nolan, Stephen J. Lippard, and Matthew D. Shoulders, J. Am. Chem. Soc., 140, 2413-2416 (2018).
Photoactivatable Sensors for Detecting Mobile Zinc. Jacob M. Goldberg, Fang Wang, Chanan D. Sessler, Nathan W. Vogler, Daniel Y. Zhang, William H. Loucks, Thanos Tzounopoulos, and Stephen J. Lippard, J. Am. Chem. Soc., 140, 2020-2023 (2018).
Anticancer activity of osmium(VI) nitrido complexes in patient-derived glioblastoma initiating cells and in vivo mouse models. Gilles Berger, Korneel Grauwet, Hong Zhang, Amanda M. Hussey, Michal O. Nowicki, David I. Wang, E. Antonio Chiocca, Sean E. Lawler, and Stephen J. Lippard, Cancer Lett., 415, 138-148 (2018).
2017
Direct ratiometric detection of nitric oxide with Cu(II)-based fluorescent probes. Andrei Loas and Stephen J. Lippard, J Mater. Chem. B, 5, 8929-8933 (2017).
Tuning the Diiron Core Geometry in Carboxylate-Bridged Macrocyclic Model Complexes Affects Their Redox Properties and Supports Oxidation Chemistry. Fang Wang, Sabine Becker, Mikael A. Minier, Andrei Loas, Megan N. Jackson, and Stephen J. Lippard, Inorg. Chem., 56, 11050-11058 (2017).
CF2H, a Hydrogen Bond Donor. Chanan D. Sessler, Martin Rahm, Sabine Becker, Jacob M. Goldberg, Fang Wang, and Stephen J. Lippard, J. Am. Chem. Soc., 139, 9325-9332 (2017).
A subset of platinum-containing chemotherapeutic agents kills cells by inducing ribosome biogenesis stress. Peter M. Bruno, Yunpeng Liu, Ga Young Park, Junko Murai, Catherine E. Koch, Timothy J. Eisen, Justin R. Pritchard, Yves Pommier, and Stephen J. Lippard, Nat. Medicine, 23, 461-471 (2017).
Challenges and Opportunities in Brain Bioinorganic Chemistry. Jacob M. Goldberg and Stephen J. Lippard, Acc. Chem. Res., 50, 577-579 (2017).
Repair shielding of Pt-DNA lesions in testicular germ cell tumors by high-mobility group box protein 4 imparts cisplatin hypersensitivity. Samuel G. Awuah, Imogen Riddell, and Stephen J. Lippard, Proc. Natl. Acad. Sci. U. S. A., 114, 950-955 (2017).
Mobile zinc increases rapidly in the retina after optic nerve injury and regulates ganglion cell survival and optic nerve regeneration. Yiqing Li, Lukas Andereggen, Kenya Yuki, Kumiko Omura, Yuqin Yin, Hui-Ya Gilbert, Burcu Erdogan, Maria S. Asdourian, Christine Schrock, Silmara de Lima, Ulf-Peter Apfel, Yehong Zhuo, Michal Hershfinkel, Stephen J. Lippard, Paul A. Rosenberg, and Larry I. Benowitz, Proc. Natl. Acad. Sci. U. S. A., 114, E209-E218 (2017).
2016
Phenanthriplatin Acts as a Covalent Poison of Topoisomerase II Cleavage Complexes. Imogen A. Riddell, Keli Agama, Ga Young Park, Yves Pommier, and Stephen J. Lippard, ACS Chem. Biol., 11, 2996-3001 (2016).
Roger Y. Tsien (1952-2016). Stephen J. Lippard, Science, 354, 41 (2016).
Metalloneurochemistry and the Pierian Spring: 'Shallow Draughts Intoxicate the Brain'. Jacob M. Goldberg, Andrei Loas, and Stephen J. Lippard, Isr. J. Chem., 56, 791-802 (2016).
Chemical Approach to Positional Isomers of Glucose–Platinum Conjugates Reveals Specific Cancer Targeting through Glucose-Transporter-Mediated Uptake in Vitro and in Vivo. Malay Patra, Samuel G. Awuah, and Stephen J. Lippard, J. Am. Chem. Soc., 138, 12541-12551 (2016).
Mechanistic studies of the anticancer activity of an octahedral hexanuclear Pt(II) cage. Yao-Rong Zheng, Kogularamanan Suntharalingam, Peter M. Bruno, Wei Lin, Weixue Wang, Michael T. Hemann, and Stephen J. Lippard, Inorg. Chim. Act., 452, 125-129 (2016).
Nucleotide Binding Preference of the Monofunctional Platinum Anticancer-Agent Phenanthriplatin. Imogen A. Riddell, Timothy C. Johnstone, Ga Young Park, and Stephen J. Lippard, Chem. - Eur. J., 22, 7574-7581 (2016).
Membrane-Permeable Mn(III) Complexes for Molecular Magnetic Resonance Imaging of Intracellular Targets. Ali Barandov, Benjamin B. Bartelle, Beatriz A. Gonzalez, William L. White, Stephen J. Lippard, and Alan Jasanoff, J. Am. Chem. Soc., 138, 5483-5486 (2016).
Achieving Reversible Sensing of Nitroxyl by Tuning the Ligand Environment of Azamacrocyclic Copper(II) Complexes. Sunghee Kim, Mikael A. Minier, Andrei Loas, Sabine Becker, Fang Wang, and Stephen J. Lippard, J. Am. Chem. Soc., 138, 1804-1807 (2016).
Tobacco Mosaic Virus Delivery of Phenanthriplatin for Cancer therapy. Anna E. Czapar, Yao-rong Zheng, Imogen A. Riddell, Sourabh Shukla, Samuel G. Awuah, Stephen J. Lippard, and Nicole F. Steinmetz, ACS Nano, 10, 4119-4126 (2016).
The Next Generation of Platinum Drugs: Targeted Pt(II) Agents, Nanoparticle Delivery, and Pt(IV) Prodrugs. Timothy C. Johnstone, Kogularamanan Suntharalingam, and Stephen J. Lippard, Chem. Rev., 116, 3436-3486 (2016).
A Potent Glucose-Platinum Conjugate Exploits Glucose Transporters and Preferentially Accumulates in Cancer Cells. Malay Patra, Timothy C. Johnstone, Kogularamanan Suntharalingam, and Stephen J. Lippard, Angew. Chem., Int. Ed., 55, 2550-2554 (2016).
Reaction-Based Probes for Imaging Mobile Zinc in Live Cells and Tissues. Melissa L. Zastrow, Robert J. Radford, Wen Chyan, Charles T. Anderson, Daniel Y. Zhang, Andrei Loas, Thanos Tzounopoulos, and Stephen J. Lippard, ACS Sensors, 1, 32-39 (2016).
2015
Cisplatin and Related Drugs. Timothy C. Johnstone, Pieter M. Pil, and Stephen J. Lippard, Reference Module in Biomedical Sciences, 1-13 (2015).
A Pt(IV) Pro-drug Preferentially Targets Indoleamine-2,3-dioxygenase, Providing Enhanced Ovarian Cancer Immuno-Chemotherapy. Samuel G. Awuah, Yao-Rong Zheng, Peter M. Bruno, Michael T. Hemann, and Stephen J. Lippard, J. Am. Chem. Soc., 137, 14854-14857 (2015).
AMPA receptor inhibition by synaptically released zinc. Bopanna I. Kalappa, Charles T. Anderson, Jacob M. Goldberg, Stephen J. Lippard, and Thanos Tzounopoulos, Proc. Natl. Acad. Sci. U. S. A., 112, 15749-15754 (2015).
Metal-Based Optical Probes for Live Cell Imaging of Nitroxyl (HNO). Pablo Rivera-Fuentes and Stephen J. Lippard, Acc. Chem. Res., 48, 2927-2934 (2015).
Tumour-associated macrophages act as a slow-release reservoir of nano-therapeutic Pt(IV) pro-drug. Miles A. Miller, Yaorong Zheng, Suresh Gadde, Christina Pfirschke, Harshal Zope, Camilla Engblom, Rainer H. Kohler, Yoshiko Iwamoto, Katherine S. Yang, Bjorn Askevold, Mikael Pittet, Stephen J. Lippard, Omid C. Farokhzad, Ralph Weissleder, Nat. Commun., 6:8692 (2015).
Tonic zinc inhibits spontaneous neuronal firing in dorsal cochlear nucleus principal neurons by enhancing glycinergic neurotransmission. Tamara Perez-Rosello, Charles T. Anderson, Cindy Ling, Stephen J. Lippard, and Thanos Tzounopoulos, Neurobiology of Disease, 81, 14-19 (2015).
19F NMR study of ligand dynamics in carboxylate-bridged diiron(II) complexes supported by a macrocyclic ligand. Mikael A. Minier and Stephen J. Lippard, Dalton Trans., 18111-18121 (2015).
Single Turnover Reveals Oxygenated Intermediates in Toluene/o-Xylene Monooxygenase in the Presence of the Native Redox Partners. Alexandria D. Liang and Stephen J. Lippard, J. Am. Chem. Soc., 137, 10520-10523 (2015).
Coupling Oxygen Consumption with Hydrocarbon Oxidation in Bacterial Multicomponent Monooxygenases. Weixue Wang, Alexandria D. Liang, and Stephen J. Lippard, Acc. Chem. Res., 48, 2632-2639 (2015).
Singlet-Triplet Gaps of Cobalt Nitrosyls: Insights from Tropocoronand Complexes. Kathrin H. Hopmann, Jeanet Conradie, Espen Tangen, Zachary J. Tonzetich, Stephen J. Lippard, and Abhik Ghosh, Inorg. Chem., 54, 7362-7367 (2015).
Solid-phase synthesis provides a modular, lysine-based platform for fluorescent discrimination of nitroxyl and biological thiols. Andrei Loas, Robert J. Radford, Alexandria D. Liang, and Stephen J. Lippard, Chem. Sci., 6, 4131-4140 (2015).
Modulation of extrasynaptic NMDA receptors by synaptic and tonic zinc. Charles T. Anderson, Robert J. Radford, Daniel Y. Zhang, Ulf-Peter Apfel, Stephen J. Lippard, and Thanos Tzounopoulos, Proc. Natl. Acad. Sci. U. S. A., 112, E2705-E2714 (2015).
Methane Monooxygenase: Functionalizing Methane at Iron and Copper. Matthew H. Sazinsky and Stephen J. Lippard, In: Sustaining Life on Planet Earth: Metalloenzymes Mastering Dioxygen and Other Chewy Gases. Metal Ions in Life Sciences, Peter M. H. Kroneck, Martha E. Sosa Torres, Eds., Springer: Cham, Switzerland, 15, 205-256 (2015).
Necroptosis-Inducing Rhenium(V) Oxo Complexes. Kogularamanan Suntharalingam, Samuel G. Awuah, Peter M. Bruno, Timothy C. Johnstone, Fang Wang, Wei Lin, Yao-Rong Zheng, Julia E. Page, Michael T. Hemann, and Stephen J. Lippard, J. Am. Chem. Soc., 137, 2967–2974 (2015).
A far-red emitting probe for unambiguous detection of mobile zinc in acidic vesicles and deep tissue. Pablo Rivera-Fuentes, Alexandra T. Wrobel, Melissa L. Zastrow, Mustafa Khan, John Georgiou, Thomas T. Luyben, John C. Roder, Kenichi Okamoto, and Stephen J. Lippard, Chem. Sci., 6, 1944-1948 (2015).
Peptide-Based, Two-Fluorophore, Ratiometric Probe for Quantifying Mobile Zinc in Biological Solutions. Daniel Y. Zhang, Maria Azrad, Wendy Demark-Wahnefried, Christopher J. Frederickson, Stephen J. Lippard, and Robert J. Radford. ACS Chem. Biol., 10, 385–389 (2015).
Encapsulation of Pt(IV) prodrugs within a Pt(II) cage for drug delivery. Yao-Rong Zheng, Kogularamanan Suntharalingam, and Stephen J. Lippard, Chem. Sci., 6, 1189-1193 (2015).
Synthesis and Characterization of Mononuclear, Pseudotetrahedral Cobalt(III) Compounds. Julia Kozhukh, Mikael A. Minier, and Stephen J. Lippard, Inorg. Chem., 54, 418-424 (2015).
Oxidative halogenation of cisplatin and carboplatin: Synthesis, spectroscopy, and crystal and molecular structures of Pt(IV) prodrugs. Timothy C. Johnstone, Sarah M. Alexander, Justin J. Wilson, and Stephen J. Lippard, Dalton Trans., 119-129 (2015).
Third row transition metals for the treatment of cancer. Timothy C. Johnstone, Kogularamanan Suntharalingam, and Stephen J. Lippard, , 373, (2015)
Methane monooxygenase: functionalizing methane at iron and copper. Matthew H. Sazinsky and Stephen J. Lippard, Met Ions Life Sci., 15, 205-256 (2015).
2014
Peptide targeting of fluorescein-based sensors to discrete intracellular locales. Robert J. Radford, Wen Chyan, and Stephen J. Lippard, Chem. Sci., 5, 4512-4516 (2014).
Synthesis of Bis(imidazole) Metal Complexes and Their Use in Rapid NO Detection and Quantification Devices. Eric Victor, Sunghee Kim, and Stephen J. Lippard, Inorg. Chem., 53, 12809-12821 (2014).
Component Interactions and Electron Transfer in Toluene/o-Xylene Monooxygenase. Alexandria D. Liang and Stephen J. Lippard, Biochemistry, 53, 7368-7375 (2014).
A Breast Cancer Stem Cell-Selective, Mammospheres-Potent Osmium(VI) Nitrido Complex. Kogularamanan Suntharalingam, Wei Lin, Timothy C. Johnstone, Peter M. Bruno, Yao-Rong Zheng, Michael T. Hemann, and Stephen J. Lippard, J. Am. Chem. Soc., 136, 14413-14416 (2014).
Light-Induced N2O Production from a Non-heme Iron-Nitrosyl Dimer. Yunbo Jiang, Takahiro Hayashi, Hirotoshi Matsumura, Loi H. Do, Amit Majumdar, Stephen J. Lippard, and Pierre Moënne-Loccoz, J. Am. Chem. Soc., 136, 12524-12527 (2014).
Improvements in the synthesis and understanding of the iodo-bridged intermediate en route to the Pt(IV) prodrug satraplatin. Timothy C. Johnstone and Stephen J. Lippard, Inorg. Chim. Acta, 424, 254-259 (2014).
Synthesis and Characterization of a Linear Dinitrosyl-Triiron Complex. Eric Victor, Mikael A. Minier, and Stephen J. Lippard, Eur. J. Inorg. Chem., 2014, 5640-5645 (2014).
Electron Transfer Control in Soluble Methane Monooxygenase. Weixue Wang, Roxana E. Iacob, Rebecca P. Luoh, John R. Engen, and Stephen J. Lippard, J. Am. Chem. Soc., 136, 9754-9762 (2014).
Addition of a Second Binding Site Increases the Dynamic Range but Alters the Cellular Localization of a Red Fluorescent Probe for Mobile Zinc. Andrei Loas, Robert J. Radford , and Stephen J. Lippard, Inorg. Chem., 53, 6491-6493 (2014).
Structural and mechanistic studies of polymerase η bypass of phenanthriplatin DNA damage. Mark T. Gregorya, Ga Young Park, Timothy C. Johnstone, Young-Sam Lee, Wei Yang, and Stephen J. Lippard, Proc. Natl. Acad. Sci. U. S. A., 111, 9133-9138 (2014).
Pt(IV) Prodrugs Designed to Bind Non-Covalently to Human Serum Albumin for Drug Delivery. Yao-Rong Zheng, Kogularamanan Suntharalingam, Timothy C. Johnstone, Hyunsuk Yoo, Wei Lin, Jamar G. Brooks, and Stephen J. Lippard, J. Am. Chem. Soc., 136, 8790-8798 (2014).
A Flexible Glutamine Regulates the Catalytic Activity of Toluene o-Xylene Monooxygenase. Alexandria D. Liang, Alexandra T. Wrobel, and Stephen J. Lippard, Biochemistry, 53, 3585-3592 (2014).
A Tetranitrosyl [4Fe-4S] Cluster Forms En Route to Roussin's Black Anion: Nitric Oxide Reactivity of [Fe4S4(LS3)L'] 2-. Eric Victor and Stephen J. Lippard, Inorg. Chem., 53, 5311-5320 (2014).
Two-photon imaging of Zn2+ dynamics in mossy fiber boutons of adult hippocampal slices. Mustafa Khana, Christian R. Goldsmith, Zhen Huang, John Georgiou, Thomas T. Luybena, John C. Rodera, Stephen J. Lippard, and Kenichi Okamotoa, Proc. Natl. Acad. Sci. U. S. A., 111, 6786-6791 (2014).
Synthetic Methods for the Preparation of Platinum Anticancer Complexes. Justin J. Wilson and Stephen J. Lippard, Chem. Rev., 114, 4470-4495 (2014).
A Fast and Selective Near-Infrared Fluorescent Sensor for Multicolor Imaging of Biological Nitroxyl (HNO). Alexandra T. Wrobel, Timothy C. Johnstone, Alexandria D. Liang, Stephen J. Lippard, and Pablo Rivera-Fuentes, J. Am. Chem. Soc., 136, 4697-4705 (2014).
Conversion between Doubly and Triply Carboxylate Bridged Bis(ethylzinc) Complexes and Formation of the (μ-Oxo)tetrazinc Carboxylate [Zn4O(ArTolCO2)6]. Mikael A. Minier and Stephen J. Lippard, Organometallics, 33, 1462-1466 (2014).
Conjugation of vitamin E analog α-TOS to Pt(IV) complexes for dual-targeting anticancer therapy. Kogularamanan Suntharalingam, Ying Song, and Stephen J. Lippard, Chem. Commun., 50, 2465-2468 (2014).
A dual-targeting, p53-independent, apoptosis-inducing platinum(II) anticancer complex, [Pt(BDIQQ)]Cl. Kogularamanan Suntharalingam, Justin J. Wilson, Wei Lin, and Stephen J. Lippard, Metallomics, 6, 437-443 (2014).
Diiron Oxidation State Control of Substrate Access to the Active Site of Soluble Methane Monooxygenase Mediated by the Regulatory Component. Weixue Wang and Stephen J. Lippard , J. Am. Chem. Soc., 136, 2244-2247 (2014).
The Chiral Potential of Phenanthriplatin and Its Influence on Guanine Binding. Timothy C. Johnstone and Stephen J. Lippard, J. Am. Chem. Soc., 136, 2126-2134 (2014).
Reaction-based fluorescent sensor for investigating mobile Zn2+ in mitochondria of healthy versus cancerous prostate cells. Wen Chyan, Daniel Y. Zhang, Stephen J. Lippard, and Robert J. Radford, Proc. Natl. Acad. Sci. U. S. A., 111, 143-148 (2014).
Effects of Monofunctional Platinum Agents on Bacterial Growth: A Retrospective Study. Timothy C. Johnstone, Sarah M. Alexander, Wei Lin, and Stephen J. Lippard, J. Am. Chem. Soc., 136, 116-118 (2014).
Versatile Reactivity of a Solvent-Coordinated Diiron(II) Compound: Synthesis and Dioxygen Reactivity of a Mixed-Valent Fe(II)Fe(III) Species. Amit Majumdar, Ulf-Peter Apfel, Yunbo Jiang, Pierre Moënne-Loccoz, and Stephen J. Lippard, Inorg. Chem., 53, 167-181 (2014).
Understanding and Improving Platinum Anticancer Drugs – Phenanthriplatin. Timothy C. Johnstone, Ga Young Park, and Stephen J. Lippard, Anticancer Res., 34, 471-476 (2014).
Reinterpretation of the vibrational spectroscopy of the medicinal bioinorganic synthon c,c,t-[Pt(NH3)2Cl2(OH)2]. Timothy C. Johnstone and Stephen J. Lippard, J. Biol. Inorg. Chem., 19, 667-674 (2014).
SpiroZin1: a Reversible and pH-Insensitive, Reaction-Based, Red-Fluorescent Probe for Imaging Biological Mobile Zinc. Pablo Rivera-Fuentes and Stephen J. Lippard, ChemMedChem, 9, 1238-1243 (2014).
2013
Enhancing tumor cell response to chemotherapy through nanoparticle-mediated codelivery of siRNA and cisplatin prodrug. Xiaoyang Xu, Kun Xie, Xue-Qing Zhang, Eric M. Pridgen, Ga Young Park, Danica S. Cui, Jinjun Shi, Jun Wu, Philip W. Kantoff, Stephen J. Lippard, Robert Langer, Graham C. Walker, and Omid C. Farokhzad, Proc. Natl. Acad. Sci. U. S. A., 110, 18638-18643 (2013).
Identification and Rescue of α-Synuclein Toxicity in Parkinson Patient-Derived Neurons. Chee Yeun Chung, Vikram Khurana, Pavan K. Auluck, Daniel F. Tardiff, Joseph R. Mazzulli, Frank Soldner, Valeriya Baru, Yali Lou, Yelena Freyzon, Sukhee Cho, Alison E. Mungenast, Julien Muffat, Maisam Mitalipova, Michael D. Pluth, Nathan T. Jui, Birgitt Schüle, Stephen J. Lippard, Li-Huei Tsai, Dimitri Krainc, Stephen L. Buchwald, Rudolf Jaenisch, and Susan Lindquist, Science, 342, 983-987 (2013).
Non-heme Mononitrosyldiiron Complexes: Importance of Iron Oxidation State in Controlling the Nature of the Nitrosylated Products. Amit Majumdar and Stephen J. Lippard, Inorg. Chem., 52, 13292-13294 (2013).
Targeting Mitochondrial DNA with a Platinum-Based Anticancer Agent. Simon P. Wisnovsky, Justin J. Wilson, Robert J. Radford, Mark P. Pereira, Maria R. Chan, Rebecca R. Laposa, Stephen J. Lippard, and Shana O. Kelley, Chem. Biol., 20, 1323-1328 (2013).
Monofunctional and Higher-Valent Platinum Anticancer Agents. Timothy C. Johnstone, Justin J. Wilson, and Stephen J. Lippard, Inorg. Chem., 52, 12234-12249 (2013).
Synthesis and Characterization of Pt(IV) Fluorescein Conjugates to Investigate Pt(IV) Intracellular Transformations. Ying Song, Kogularamanan Suntharalingam, Jessica S. Yeung, Maksim Royzen, and Stephen J. Lippard, Bioconjugate Chem., 24, 1733-1740 (2013).
Bidentate Ligands on Osmium(VI) Nitrido Complexes Control Intracellular Targeting and Cell Death Pathways. Kogularamanan Suntharalingam, Timothy C. Johnstone, Peter M. Bruno, Wei Lin, Michael T. Hemann, and Stephen J. Lippard, J. Am. Chem. Soc., 135, 14060-14063 (2013).
Specific Visualization of Nitric Oxide in the Vasculature with Two-Photon Microscopy Using a Copper Based Fluorescent Probe. Mitrajit Ghosh, Nynke M. S. van den Akker, Karolina A. P. Wijnands, Martijn Poeze, Christian Weber, Lindsey E. McQuade, Michael D. Pluth, Stephen J. Lippard, Mark J. Post, Daniel G. M. Molin, and Marc A. M. J. van Zandvoort, PLos ONE, 8, e75331 (2013).
Visualization of Peroxynitrite-Induced Changes of Labile Zn2+ in the Endoplasmic Reticulum with Benzoresorufin-Based Fluorescent Probes. Wei Lin, Daniela Buccella, and Stephen J. Lippard, J. Am. Chem. Soc., 135, 13512-13520 (2013).
Effect of a Monofunctional Phenanthriplatin-DNA Adduct on RNA Polymerase II Transcriptional Fidelity and Translesion Synthesis. Matthew W. Kellinger, Ga Young Park, Jenny Chong, Stephen J. Lippard, and Dong Wang, J. Am. Chem. Soc., 135, 13054-13061 (2013).
The Effect of Ligand Lipophilicity on the Nanoparticle Encapsulation of Pt(IV) Prodrugs. Timothy C. Johnstone and Stephen J. Lippard, Inorg. Chem., 52, 9915-9920 (2013).
Peptide-based targeting of fluorescent zinc sensors to the plasma membrane of live cells. Robert J. Radford, Wen Chyan, and Stephen J. Lippard, Chem. Sci., 4, 3080-3084 (2013).
Nanoparticle Encapsulation of Mitaplatin and the Effect Thereof on In Vivo Properties. Timothy C. Johnstone, Nora Kulak, Eric M. Pridgen, Omid C. Farokhzad, Robert Langer, and Stephen J. Lippard, ACS Nano, 7, 5675-5683 (2013).
Visualizing Inhibition of Nucleosome Mobility and Transcription by Cisplatin-DNA Interstrand Crosslinks in Live Mammalian Cells. Guangyu Zhu, Lina Song, and Stephen J Lippard, Cancer Res., 73, 4451-4460 (2013).
Tris(2-pyridylmethyl)amine (TPA) as a membrane-permeable chelator for interception of biological mobile zinc. Zhen Huang, Xiao-an Zhang, Miquel Bosch, Sarah J. Smith, and Stephen J. Lippard, Metallomics, 5, 648-655 (2013).
Synergistic cytotoxicity of irinotecan and cisplatin in dual-drug targeted polymeric nanoparticles. Pedro M, Valencia, Eric M. Pridgen, Brian Perea, Suresh Gadde, Christopher Sweeney, Philip W. Kantoff, Stephen J. Lippard, Robert Langer, Rohit Karnik, and Omid C. Farokhzad, Nanomedicine, 8, 687-698 (2013).
Oxidative reactivity and cytotoxic properties of a platinum(II) complex prepared by outer-sphere amide bond coupling. Justin J. Wilson and Stephen J. Lippard, Polyhedron, 58, 71-78 (2013).
Chelators for investigating zinc metalloneurochemistry. Robert J. Radford and Stephen J. Lippard, Curr. Opin. Chem. Biol., 17, 129-136 (2013).
Triptycene-Based, Carboxylate-Bridged Biomimetic Diiron(II) Complexes. Yang Li, Chan Myae Myae Soe, Justin J. Wilson, Suan Lian Tuang, Ulf-Peter Apfel, and Stephen J. Lippard, Eur. J. Inorg. Chem., 2013, 2011-2019 (2013).
Aging-Associated Enzyme Human Clock-1: Substrate-Gated Reduction of the Diiron Center for 5-Demethoxyubiquinone Hydroxylation. Tsai-Te Lu, Seung Jae Lee, Ulf-Peter Apfel, and Stephen J. Lippard, Biochemistry, 52, 2236-2244 (2013).
Detection of Nitric Oxide and Nitroxyl with Benzoresorufin-Based Fluorescent Sensors. Ulf-Peter Apfel, Daniela Buccella, Justin J. Wilson, and Stephen J. Lippard, Inorg.Chem., 52, 3285-3294 (2013).
Conformational isomerism of trans-[Pt(NH2C6H11)2I2] and the classical Wernerian chemistry of [Pt(NH2C6H11)4]X2 (X = Cl, Br, I). Timothy C. Johnstone and Stephen J. Lippard, Polyhedron, 52, 565-575 (2013).
Zinc released from olfactory bulb glomeruli by patterned electrical stimulation of the olfactory nerve. Laura J. Blakemore, Elisa Tomat, Stephen J. Lippard, and Paul Q. Trombley, Metallomics, 5, 208-213 (2013).
Photoluminescent DNA binding and cytotoxic activity of a platinum(II) complex bearing a tetradentate β-diketiminate ligand. Jennifer M. Hope, Justin J. Wilson, and Stephen J. Lippard, Dalton Trans., 3176-3180 (2013).
Control of substrate access to the active site in methane monooxygenase. Seung Jae Lee, Michael S. McCormick, Stephen J. Lippard, and Uhn-Soo Cho, Nature, 494, 380-384 (2013).
Physical and structural properties of [Cu(BOT1)Cl]Cl, a fluorescent imaging probe for HNO. Maksim Royzen, Justin J. Wilson, and Stephen J. Lippard, J. Inorg. Biochem., 118, 162-170 (2013).
2012
Reactions of Organozinc Thiolates with Nitrosonium Ion: C-Nitroso Formation by Intramolecular Transnitrosation. Julia Kozhukh, Juliana Fedoce Lopes, Hélios F. Dos Santos, and Stephen J. Lippard, Organometallics, 31, 8063-8066 (2012).
Reversible binding of nitric oxide to an Fe(III) complex of a tetra-amido macrocycle. Michael D. Pluth and Stephen J. Lippard, Chem. Commun., 48, 11981-11983 (2012).
Acetate-Bridged Platinum(III) Complexes Derived from Cisplatin. Justin J. Wilson and Stephen J. Lippard, Inorg. Chem., 51, 9852-9864 (2012).
Variable Nitric Oxide Reactivity of Tropocoronand Cobalt(III) Nitrite Complexes as a Function of the Polymethylene Linker Chain Length. Julia Kozhukh and Stephen J. Lippard, Inorg. Chem., 51, 9416-9422 (2012).
Role of Ca2+ in the Control of H2O2-Modulated Phosphorylation Pathways Leading to eNOS Activation in Cardiac Myocytes. Juliano L. Sartoretto, Hermann Kalwa, Takashi Shiroto, Simone M. Sartoretto, Michael D. Pluth, Stephen J. Lippard, and Thomas Michel, PLoS ONE, 7, e44627 (2012).
Zinc Thiolate Reactivity toward Nitrogen Oxides: Insights into the Interaction of Zn2+ with S-Nitrosothiols and Implications for Nitric Oxide Synthase. Julia Kozhukh and Stephen J. Lippard, Inorg. Chem., 51, 7346-7353 (2012).
Binding Interaction of HMGB4 with Cisplatin-Modified DNA. Semi Park and Stephen J. Lippard, Biochemistry, 51, 6728-6737 (2012).
Chemical Characterization of the Smallest S-Nitrosothiol, HSNO; Cellular Cross-talk of H2S and S-Nitrosothiols. Milos R. Filipovic, Jan Lj. Miljkovic, Thomas Nauser, Maksim Royzen, Katharina Klos, Tatyana Shubina, Willem H. Koppenol, Stephen J. Lippard, and Ivana Ivanović-Burmazović, J. Am. Chem. Soc., 134, 12016-12027 (2012).
Redox activation of metal-based prodrugs as a strategy for drug delivery. Nora Graf and Stephen J. Lippard, Advanced Drug Delivery Reviews, 64, 993-1004 (2012).
Phenanthriplatin, a monofunctional DNA-binding platinum anticancer drug candidate with unusual potency and cellular activity profile. Ga Young Park, Justin J. Wilson, Ying Song, and Stephen J. Lippard, Proc. Natl. Acad. Sci. U. S. A., 109, 11987-11992 (2012).
A C2-symmetric, basic Fe(III) carboxylate complex derived from a novel triptycene-based chelating carboxylate ligand. Yang Li, Justin J. Wilson, Loi H. Do, Ulf-Peter Apfel, and Stephen J. Lippard, Dalton Trans., 9272-9275 (2012).
Influence of Tetraazamacrocyclic Ligands on the Nitric Oxide Reactivity of their Cobalt(II) Complexes. Julia Kozhukh and Stephen J. Lippard, J. Am. Chem. Soc., 134, 11120-11123 (2012).
In Vitro Anticancer Activity of cis-Diammineplatinum(II) Complexes with ß-Diketonate Leaving Group Ligands. Justin J. Wilson and Stephen J. Lippard, J. Med. Chem., 55, 5326-5336 (2012).
aVß3 Integrin-Targeted PLGA-PEG Nanoparticles for Enhanced Anti-tumor Efficacy of a Pt(IV) Prodrug. Nora Graf, Diane R. Bielenberg, Nagesh Kolishetti, Christoph Muus, Jacqueline Banyard, Omid C. Farokhzad, and Stephen J. Lippard, ACS Nano, 6, 4530-4539 (2012).
Modulation of ligand fluorescence by the Pt(II)/Pt(IV) redox couple. Justin J. Wilson and Stephen J. Lippard, Inorg. Chim. Acta, 389, 77-84 (2012).
Platinum(IV)-chlorotoxin (CTX) conjugates for targeting cancer cells. Nora Graf, Tara E. Mokhtari, Ioannis A. Papayannopoulos, and Stephen J. Lippard, J. Inorg. Biochem., 110, 58-63 (2012).
Evaluating the Identity and Diiron Core Transformations of a (μ-Oxo)diiron(III) Complex Supported by Electron-Rich Tris(pyridyl-2-methyl)amine Ligands. Loi H. Do, Genqiang Xue, Lawrence Que, Jr., and Stephen J. Lippard, Inorg. Chem., 51, 2393-2402 (2012).
Monofunctional Platinum–DNA Adducts Are Strong Inhibitors of Transcription and Substrates for Nucleotide Excision Repair in Live Mammalian Cells. Guangyu Zhu, MyatNoeZin Myint, Wee Han Ang, Lina Song, and Stephen J. Lippard, Cancer Research, 72, 790-800 (2012).
Illuminating Mobile Zinc with Fluorescence: From Cuvettes to Live Cells and Tissues. Zhen Huang and Stephen J. Lippard, Methods in Enzymology, 505, 445-468 (2012).
2011
Analysis of Substrate Access to Active Sites in Bacterial Multicomponent Monooxygenase Hydroxylases: X-Ray Crystal Structure of Xenon-Pressurized Phenol Hydroxylase from Pseudomonas sp. OX1. Michael S. McCormick and Stephen J. Lippard, Biochemistry, 50, 11058-11069 (2011).
Synthesis, Photophysics, Electrochemistry, and Electrogenerated Chemiluminescence of a Homologous Set of BODIPY-Appended Bipyridine Derivatives. Joel Rosenthal, Alexander B. Nepomnyashchii, Julia Kozhukh, Allen J. Bard, and Stephen J. Lippard, J. Phys. Chem. C, 115, 17993-18001 (2011).
Evolution of strategies to prepare synthetic mimics of carboxylate-bridged diiron protein active sites. Loi H. Do and Stephen J. Lippard, J. Inorg. Biochem., 105, 1774-1785 (2011).
Spectrum of Cellular Responses to Pyriplatin, a Monofunctional Cationic Antineoplastic Platinum(II) Compound, in Human Cancer Cells. Katherine S. Lovejoy, Maria Serova, Ivan Bieche, Shahin Emami, Maurizio D'Incalci, Massimo Broggini, Eugenio Erba, Christian Gespach, Esteban Cvitkovic, Sandrine Faivre, Eric Raymond, and Stephen J. Lippard, Molecular Cancer Therapeutics, 10, 1709-1719 (2011).
Phosphorescent Sensor for Biological Mobile Zinc. Youngmin You, Sumin Lee, Taehee Kim, Kei Ohkubo, Weon-Sik Chae, Shunichi Fukuzumi Gil-Ja Jhon, Wonwoo Nam, and Stephen J. Lippard, J. Am. Chem. Soc., 133, 18328-18342 (2011).
Vesicular Zinc Promotes Presynaptic and Inhibits Postsynaptic Long-Term Potentiation of Mossy Fiber-CA3 Synapse. Enhui Pan, Xiao-an Zhang, Zhen Huang, Artur Krezel, Min Zhao, Christine E. Tinberg, Stephen J. Lippard, and James O. McNamara, Neuron, 71, 1116-1126 (2011).
Generation, Translocation, and Action of Nitric Oxide in Living Systems. Andrew G. Tennyson and Stephen J. Lippard, Chem. Biol., 18, 1211-1220 (2011).
Hydrogen peroxide differentially modulates cardiac myocyte nitric oxide synthesis. Juliano L. Sartoretto, Hermann Kalwa, Michael D. Pluth, Stephen J. Lippard, and Thomas Michel, Proc. Natl. Acad. Sci. U. S. A., 108, 15792-15797 (2011).
Design and Synthesis of a Novel Triptycene-Based Ligand for Modeling Carboxylate-Bridged Diiron Enzyme Active Sites. Yang Li, Rui Cao, and Stephen J. Lippard, Org. Lett., 13, 5052-5055 (2011).
Immobilization, Trapping, and Anion Exchange of Perrhenate Ion Using Copper-Based Tripodal Complexes. Rui Cao, Brian D. McCarthy, and Stephen J. Lippard, Inorg. Chem., 50, 9499-9507 (2011).
Seminaphthofluorescein-Based Fluorescent Probes for Imaging Nitric Oxide in Live Cells. Michael D. Pluth, Maria R. Chan, Lindsey E. McQuade, Stephen J. Lippard, Inorg. Chem., 50, 9385-9392 (2011).
Characterization of a synthetic peroxodiiron(III) protein model complex by nuclear resonance vibrational spectroscopy. Loi H. Do, Hongxin Wang, Christine E. Tinberg, Eric Dowty, Yoshitaka Yoda, Stephen P. Cramer, and Stephen J. Lippard, Chem. Commun., 47, 10945-10947 (2011).
Tracking a defined route for O2 migration in a dioxygen-activating diiron enzyme. Woon Ju Song, Grant Gucinski, Matthew H. Sazinsky, and Stephen J. Lippard, Proc. Natl. Acad. Sci. U. S. A., 108, 14795-14800 (2011).
Phosphorescent Sensor for Robust Quantification of Copper(II) Ion. Youngmin You, Yejee Han, Yong-Min Lee, Soo Young Park, Wonwoo Nam, and Stephen J. Lippard, J. Am. Chem. Soc., 133, 11488-11491 (2011).
Toward Functional Carboxylate-Bridged Diiron Protein Mimics: Achieving Structural Stability and Conformational Flexibility Using a Macrocyclic Ligand Framework. Loi H. Do and Stephen J. Lippard, J. Am. Chem. Soc., 133, 10568-10581 (2011).
Redox State-Dependent Interaction of HMGB1 and Cisplatin-Modified DNA. Semi Park and Stephen J. Lippard, Biochemistry, 50, 2567-2574 (2011).
Mechanistic Studies of Reactions of Peroxodiiron(III) Intermediates in T201 Variants of Toluene/o-Xylene Monooxygenase Hydroxylase. Woon Ju Song and Stephen J. Lippard, Biochemistry, 50, 5391-5399 (2011).
Biochemistry of Mobile Zinc and Nitric Oxide Revealed by Fluorescent Sensors. Michael D. Pluth, Elisa Tomat, and Stephen J. Lippard, Annu. Rev. Biochem., 80, 333-355 (2011).
Insights into the Different Dioxygen Activation Pathways of Methane and Toluene Monooxygenase Hydroxylase. Arteum D. Bochevarov, Jianing Li, Woon Ju Song, Richard A. Friesner, and Stephen J. Lippard, J. Am. Chem. Soc., 133, 7384-7397 (2011).
Role of Endonucleases XPF and XPG in Nucleotide Excision Repair of Platinated DNA and Cisplatin/Oxaliplatin Cytotoxicity. Nora Graf, Wee Han Ang, Guangyu Zhu, MyatNoeZin Myint, and Stephen J. Lippard, ChemBioChem, 12, 1115-1123 (2011).
Dioxygen Activation in Soluble Methane Monooxygenase. Christine E. Tinberg and Stephen J. Lippard, Acc. Chem. Res., 44, 280-288 (2011).
Understanding Zinc Quantification with Existing and Advanced Ditopic Fluorescent Zinpyr Sensors. Daniela Buccella, Joshua A. Horowitz, and Stephen J. Lippard, J. Am. Chem. Soc., 133, 4101-4114 (2011).
Synthesis, Characterization, and Cytotoxicity of Platinum(IV) Carbamate Complexes. Justin J. Wilson and Stephen J. Lippard, Inorg. Chem., 50, 3103-3115 (2011).
Multiple Roles of Component Proteins in Bacterial Multicomponent Monooxygenases: Phenol Hydroxylase and Toluene/o-Xylene Monooxygenase from Pseudomonas sp. OX1. Christine E. Tinberg, Woon Ju Song, Viviana Izzo, and Stephen J. Lippard, Biochemistry, 50, 1788-1798 (2011).
Current Status and Mechanism of Action of Platinum-Based Anticancer Drugs. Shanta Dhar and Stephen J. Lippard, In: Bioinorganic Medicinal Chemistry, Enzo Alessio, Ed., Wiley-VCH: Weinheim, Germany, 79-95 (2011).
Chemistry of Nitrosyliron Complexes Supported by a β-Diketiminate Ligand. Zachary J. Tonzetich, Florent Héroguel, Loi H. Do, and Stephen J. Lippard, Inorg. Chem., 50, 1570-1579 (2011).
Targeted delivery of a cisplatin prodrug for safer and more effective prostate cancer therapy in vivo. Shanta Dhar, Nagesh Kolishetti, Stephen J. Lippard, and Omid C. Farokhzad, Proc. Natl. Acad. Sci. U. S. A., 108, 1850-1855 (2011).
2010
Prediction of 57Fe Mössbauer Parameters by Density Functional Theory: A Benchmark Study. Arteum D. Bochevarov, Richard A. Friesner, and Stephen J. Lippard, J. Chem. Theory Comput., 6, 3735-3749 (2010).
Characterization of Iron Dinitrosyl Species Formed in the Reaction of Nitric Oxide with a Biological Rieske Center. Christine E. Tinberg, Zachary J. Tonzetich, Hongxin Wang, Loi H. Do, Yoshitaka Yoda, Stephen P. Cramer, and Stephen J. Lippard, J. Am. Chem. Soc., 132, 18168-18176 (2010).
Consequences of Cisplatin Binding on Nucleosome Structure and Dynamics. Ryan C. Todd and Stephen J. Lippard, Chem. Biol., 17, 1334-1343 (2010).
Tripodal Tris-tacn and Tris-dpa Platforms for Assembling Phosphate-Templated Trimetallic Centers. Rui Cao, Peter Müller, and Stephen J. Lippard, J. Am. Chem. Soc., 132, 17366-17369 (2010).
A Highly Selective Turn-On Colorimetric, Red Fluorescent Sensor for Detecting Mobile Zinc in Living Cells. Pingwu Du and Stephen J. Lippard, Inorg. Chem., 49, 10753-10755 (2010).
The Aging-Associated Enzyme CLK-1 Is a Member of the Carboxylate-Bridged Diiron Family of Proteins. Rachel K. Behan and Stephen J. Lippard, Biochemistry, 49, 9679-9681 (2010).
Engineering of self-assembled nanoparticle platform for precisely controlled combination drug therapy. Nagesh Kolishetti, Shanta Dhar, Pedro M. Valencia, Lucy Q. Lin, Rohit Karnik, Stephen J. Lippard, Robert Langer, and Omid C. Farokhzad, Proc. Natl. Acad. Sci. U. S. A., 107, 17939-17944 (2010).
The Interface of Inorganic Chemistry and Biology. Stephen J. Lippard, J. Am. Chem. Soc., 132, 14689-14693 (2010).
Ratiometric and Intensity-Based Zinc Sensors Built on Rhodol and Rhodamine Platforms. Elisa Tomat and Stephen J. Lippard, Inorg. Chem., 49, 9113-9115 (2010).
Cell-Trappable Quinoline-Derivatized Fluoresceins for Selective and Reversible Biological Zn(II) Detection. Lindsey E. McQuade and Stephen J. Lippard, Inorg. Chem., 49, 9535-9545 (2010).
Active Site Threonine Facilitates Proton Transfer during Dioxygen Activation at the Diiron Center of Toluene/o-Xylene Monooxygenase Hydroxylase. Woon Ju Song, Michael S. McCormick, Rachel K. Behan, Matthew H. Sazinsky, Wei Jiang, Jeffery Lin, Carsten Krebs, and Stephen J. Lippard, J. Am. Chem. Soc., 132, 13582-13585 (2010).
Oxidation Reactions Performed by Soluble Methane Monooxygenase Hydroxylase Intermediates Hperoxo and Q Proceed by Distinct Mechanisms. Christine E. Tinberg and Stephen J. Lippard, Biochemistry, 49, 7902-7912 (2010).
Mechanism of Nitric Oxide Reactivity and Fluorescence Enhancement of the NO-Specific Probe CuFL1. Lindsey E. McQuade, Michael D. Pluth, and Stephen J. Lippard, Inorg. Chem., 49, 8025-8033 (2010).
Fluorescence-Based Nitric Oxide Sensing by Cu(II) Complexes That Can Be Trapped in Living Cells. Lindsey E. McQuade and Stephen J. Lippard, Inorg. Chem., 49, 7464-7471 (2010).
Detecting and Understanding the Roles of Nitric Oxide in Biology. Zachary J. Tonzetich, Lindsey E. McQuade, and Stephen J. Lippard, Inorg. Chem., 49, 6338-6348 (2010).
Recognition of Platinum-DNA Damage by Poly(ADP-ribose) Polymerase-1. Guangyu Zhu, Paul Chang, and Stephen J. Lippard, Biochemistry, 49, 6177-6183 (2010).
A Novel Imaging Approach for Early Detection of Prostate Cancer Based on Endogenous Zinc Sensing. Subrata K. Ghosh, Pilhan Kim, Xiao-an Zhang, Seok-Hyun Yun, Anna Moore, Stephen J. Lippard, and Zdravka Medarova, Cancer Research, 70, 6119-6127 (2010).
Structure of duplex DNA containing the cisplatin 1,2-{Pt(NH3)2}2+-d(GpG) cross-link at 1.77 Å resolution. Ryan C. Todd, Stephen J. Lippard, J. Inorg. Biochem., 104, 902-908 (2010).
Current challenges of modeling diiron enzyme active sites for dioxygen activation by biomimetic synthetic complexes. Simone Friedle, Erwin Reisner, and Stephen J. Lippard, Chem. Soc. Rev., 39, 2768-2779 (2010).
In Vivo Imaging with a Cell-Permeable Porphyrin-Based MRI Contrast Agent. Taekwan Lee, Xiao-an Zhang, Shanta Dhar, Henryk Faas, Stephen J. Lippard, and Alan Jasanoff, Chem. Biol., 17, 665-673, (2010).
Manganese displacement from Zinpyr-1 allows zinc detection by fluorescence microscopy and magnetic resonance imaging. Youngmin You, Elisa Tomat, Kevin Hwang, Tatjana Atanasijevic, Wonwoo Nam, Alan P. Jasanoff, and Stephen J. Lippard, Chem. Commun., 46, 4139-4141 (2010).
X-ray structure and mechanism of RNA polymerase II stalled at an antineoplastic monofunctional platinum-DNA adduct. Dong Wang, Guangyu Zhu, Xuhui Huang, and Stephen J. Lippard, Proc. Natl. Acad. Sci. U. S. A., 107, 9584-9589 (2010).
Transcription Inhibition by Platinum DNA Cross-Links in Live Mammalian Cells. Wee Han Ang, MyatNoeZin Myint, and Stephen J. Lippard, J. Am. Chem. Soc., 132, 7429-7435 (2010).
Synthesis, Characterization, and Photophysical Properties of Three Pt(II) Complexes Bearing Fluorescent Analogues of the Di-2-pyridylmethane Ligand. Justin J. Wilson, Juliana Fedoce Lopes, and Stephen J. Lippard, Inorg. Chem., 49, 5303-5315 (2010).
Identification of Protein-Bound Dinitrosyl Iron Complexes by Nuclear Resonance Vibrational Spectroscopy. Zachary J. Tonzetich, Hongxin Wang, Devrani Mitra, Christine E. Tinberg, Loi H. Do, Francis E. Jenney, Jr., Michael W. W. Adams, Stephen P. Cramer, and Stephen J. Lippard, J. Am. Chem. Soc., 132, 6914-6916 (2010).
Cell-Trappable Fluorescent Probes for Nitric Oxide Visualization in Living Cells. Michael D. Pluth, Lindsey E. McQuade, and Stephen J. Lippard, Org. Lett., 12, 2318-2321 (2010).
Electronic Structure of a Paramagnetic {MNO}6 Complex: MnNO 5,5-Tropocoronand. Espen Tangen, Jeanet Conradie, Katherine Franz, Simone Friedle, Joshua Telser, Stephen J. Lippard, and Abhik Ghosh, Inorg. Chem., 49, 2701-2705 (2010).
MRI Sensing Based on Displacement of Paramagnetic Ions from Chelated Complexes. Tatjana Atanasijevic, Xiao-an Zhang, Stephen J. Lippard, and Alan Jasanoff, Inorg. Chem., 49, 2589-2591 (2010).
Visualization of nitric oxide production in the mouse main olfactory bulb by a cell-trappable copper(II) fluorescent probe. Lindsey E. McQuade, Jie Ma, Graeme Lowe, Ambarish Ghatpande, Alan Gelperin, and Stephen J. Lippard, Proc. Natl. Acad. Sci. U. S. A., 107, 8525-8530 (2010).
Direct Detection of Nitroxyl in Aqueous Solution Using a Tripodal Copper(II) BODIPY Complex. Joel Rosenthal and Stephen J. Lippard, J. Am. Chem. Soc., 132, 5536-5537 (2010).
Chronic cisplatin treatment promotes enhanced damage repair and tumor progression in a mouse model of lung cancer. Trudy G. Oliver, Kim L. Mercer, Leanne C. Sayles, James R. Burke, Diana Mendus, Katherine S. Lovejoy, Mei-Hsin Cheng, Aravind Subramanian, David Mu, Scott Powers, Denise Crowley, Roderick T. Bronson, Charles A. Whittaker, Arujun Bhutkar, Stephen J. Lippard, Todd Golub, Juergen Thomale, Tyler Jacks, and E. Alejandro Sweet-Cordero, Genes Dev., 24, 837-852 (2010).
Carboxylate as the Protonation Site in (Peroxo)diiron(III) Model Complexes of Soluble Methane Monooxygenase and Related Diiron Proteins. Loi H. Do, Takahiro Hayashi, Pierre Möenne-Loccoz, and Stephen J. Lippard, J. Am. Chem. Soc., 132, 1273-1275 (2010).
Fluorescent probes to investigate nitric oxide and other reactive nitrogen species in biology (truncated form: fluorescent probes of reactive nitrogen species). Lindsey E. McQuade and Stephen J. Lippard, Curr. Opin. Chem. Biol., 14, 43-49 (2010).
Imaging mobile zinc in biology. Elisa Tomat and Stephen J. Lippard, Curr. Opin. Chem. Biol., 14, 225-230 (2010).
2009
Mitaplatin, a potent fusion of cisplatin and the orphan drug dichloroacetate. Shanta Dhar and Stephen J. Lippard, Proc. Natl. Acad. Sci. U. S. A., 106, 22199-22204 (2009).
Revisiting the Mechanism of Dioxygen Activation in Soluble Methane Monooxygenase from M. capsulatus (Bath): Evidence for a Multi-Step, Proton-Dependent Reaction Pathway. Christine E. Tinberg and Stephen J. Lippard, Biochemistry, 48, 12145-12158 (2009).
Synthesis, Characterization, and Oxygenation Studies of Carboxylate-Bridged Diiron(II) Complexes with Aromatic Substrates Tethered to Pyridine Ligands and the Formation of a Unique Trinuclear Complex. Simone Friedle and Stephen J. Lippard, Eur. J. Inorg. Chem., 2009, 5506-5515 (2009).
Non-traditional platinum compounds for improved accumulation, oral bioavailability, and tumor targeting. Katherine S. Lovejoy and Stephen J. Lippard, Dalton Trans., 10651-10659 (2009).
2-Phenoxypyridyl Dinucleating Ligands for Assembly of Diiron(II) Complexes: Efficient Reactivity with O2 to Form (μ-Oxo)diiron(III) Units. Loi H. Do and Stephen J. Lippard, Inorg. Chem., 48, 10708-10719 (2009).
Polyvalent Oligonucleotide Gold Nanoparticle Conjugates as Delivery Vehicles for Platinum(IV) Warheads. Shanta Dhar, Weston L. Daniel, David A. Giljohann, Chad A. Mirkin, and Stephen J. Lippard, J. Am. Chem. Soc., 131, 14652-14653 (2009).
Modeling the Syn Disposition of Nitrogen Donors in Non-Heme Diiron Enzymes. Synthesis, Characterization, and Hydrogen Peroxide Reactivity of Diiron(III) Complexes with the Syn N-Donor Ligand H2BPG2DEV. Simone Friedle, Jeremy J. Kodanko, Anna J. Morys, Takahiro Hayashi, Pierre Moënne-Loccoz, and Stephen J. Lippard, J. Am. Chem. Soc., 131, 14508-14520 (2009).
Functional consequence of plasmid DNA modified site-specifically with 7-deaza-dexoyadenosine at a single, programmable site. Wee Han Ang and Stephen J. Lippard, Chem. Commun., 5820-5822 (2009).
Inhibition of transcription by platinum antitumor compounds. Ryan C. Todd and Stephen J. Lippard, Metallomics, 1, 280-291 (2009).
Subtle Modification of 2,2-Dipicolylamine Lowers the Affinity and Improves the Turn-On of Zn(II)-Selective Fluorescent Sensors. Brian A. Wong, Simone Friedle, and Stephen J. Lippard, Inorg. Chem., 48, 7009-7011 (2009).
Dinitrosyl Iron Complexes Relevant to Rieske Cluster Nitrosylation. Zachary J. Tonzetich, Loi H. Do, and Stephen J. Lippard, J. Am. Chem. Soc., 131, 7964-7965 (2009).
Photoaffinity Labeling Reveals Nuclear Proteins that Uniquely Recognize Cisplatin–DNA Interstrand Cross-Links. Guangyu Zhu and Stephen J. Lippard, Biochemistry, 48, 4916-4925 (2009).
Preparation of Mammalian Expression Vectors Incorporating Site-Specifically Platinated-DNA Lesions. Wee Han Ang, William Wesley Brown, and Stephen J. Lippard, Bioconjugate Chem., 20, 1058-1063 (2009).
Solution and Fluorescence Properties of Symmetric Dipicolylamine-Containing Dichlorofluorescein-Based Zn2+ Sensors. Brian A. Wong, Simone Friedle, and Stephen J. Lippard, J. Am. Chem. Soc., 131, 7142-7152 (2009).
Characterization of a Peroxodiiron(III) Intermediate in the T201S Variant of Toluene/o-Xylene Monooxygenase Hydroxylase from Pseudomonas sp. OX1. Woon Ju Song, Rachel K. Behan, Sunil G. Naik, Boi Hanh Huynh, and Stephen J. Lippard, J. Am. Chem. Soc., 131, 6074-6075 (2009).
Structural and Mechanistic Studies of Anticancer Platinum Drugs: Uptake, Activation, and the Cellular Response to DNA Binding. Shanta Dhar and Stephen J. Lippard, In: Platinum and Other Heavy Metal Compounds in Cancer Chemotherapy. Molecular Mechanisms and Clinical Applications, Andrea Bonetti, Roberto Leone, Franco M. Muggia, Stephen B. Howell, Eds., Humana Press: Totowa, NJ, 135-147 (2009).
X-ray Crystal Structure of a Monofunctional Platinum–DNA Adduct, cis-{Pt(NH3)2-(Pyridine)}2+ Bound to Deoxyguanosine in a Dodecamer Duplex. Ryan C. Todd and Stephen J. Lippard, In: Platinum and Other Heavy Metal Compounds in Cancer Chemotherapy. Molecular Mechanisms and Clinical Applications, Andrea Bonetti, Roberto Leone, Franco M. Muggia, Stephen B. Howell, Eds., Humana Press: Totowa, NJ, 67-72 (2009).
Small-Molecule Fluorescent Sensors for Investigating Zinc Metalloneurochemistry. Elizabeth M. Nolan and Stephen J. Lippard, Acc. Chem. Res., 42, 193-203 (2009).
The State of the Art of Chemical Biology. Karl-Heinz Altmann, Johannes Buchner, Horst Kessler, François Diederich, Bernhard Kräutler, Stephen J. Lippard, Rob Liskamp, Klaus Müller, Elizabeth M. Nolan, Bruno Samorì, Gisbert Schneider, Stuart L. Schreiber, Harald Schwalbe, Claudio Toniolo, Constant A. A. van Boeckel, Herbert Waldmann, and Christopher T. Walsh, ChemBioChem, 10, 16-29 (2009).
Photoaffinity Isolation and Identification of Proteins in Cancer Cell Extracts that Bind to Platinum-Modified DNA. Evan R. Guggenheim, Dong Xu, Christiana X. Zhang, Pamela V. Chang, and Stephen J. Lippard, ChemBioChem, 10, 141-157 (2009).
2008
New Strategy for Quantifying Biological Zinc by a Modified Zinpyr Fluorescence Sensor. Xiao-an Zhang, Dugan Hayes, Sarah J. Smith, Simone Friedle, and Stephen J. Lippard, J. Am. Chem. Soc., 130, 15788-15789 (2008).
Organelle-Specific Zinc Detection Using Zinpyr-Labeled Fusion Proteins in Live Cells. Elisa Tomat, Elizabeth M. Nolan, Jacek Jaworski, and Stephen J. Lippard, J. Am. Chem. Soc., 130, 15776-15777 (2008).
Reactions of Synthetic [2Fe-2S] and [4Fe-4S] Clusters with Nitric Oxide and Nitrosothiols. Todd C. Harrop, Zachary J. Tonzetich, Erwin Reisner, and Stephen J. Lippard, J. Am. Chem. Soc., 130, 15602-15610 (2008).
Poly(ADP-ribose) polymerase-1 activity facilitates the dissociation of nuclear proteins from platinum-modified DNA. Evan R. Guggenheim, Alison E. Ondrus, Mohammad Movassaghi, and Stephen J. Lippard, Bioorg. Med. Chem., 16, 10121-10128 (2008).
Synthesis and Characterization of {Ni(NO)}10 and {Co(NO)2}10 Complexes Supported by Thiolate Ligands. Andrew G. Tennyson, Shanta Dhar, and Stephen J. Lippard, J. Am. Chem. Soc., 130, 15087-15098 (2008).
Targeted delivery of cisplatin to prostate cancer cells by aptamer functionalized Pt(IV) prodrug-PLGA-PEG nanoparticles. Shanta Dhar, Frank X. Gu, Robert Langer, Omid C. Farokhzad, and Stephen J. Lippard, Proc. Natl. Acad. Sci. U. S. A., 105, 17356-17361 (2008).
9-Triptycenecarboxylate-bridged diiron(II) complexes: Capture of the paddlewheel geometric isomer. Simone Friedle, Jeremy J. Kodanko, Kyrstin L. Fornace, Stephen J. Lippard, J. Mol. Struct., 890, 317-327 (2008).
Tools and Tactics for the Optical Detection of Mercuric Ion. Elizabeth M. Nolan and Stephen J. Lippard, Chem. Rev., 108, 3443-3480 (2008).
Targeted Single-Wall Carbon Nanotube-Mediated Pt(IV) Prodrug Delivery Using Folate as a Homing Device. Shanta Dhar, Zhuang Liu, Jürgen Thomale, Hongjie Dai, and Stephen J. Lippard, J. Am. Chem. Soc., 130, 11467-11476 (2008).
cis-Diammine(pyridine)chloroplatinum(II), a monofunctional platinum(II) antitumor agent: Uptake, structure, function, and prospects. Katherine S. Lovejoy, Ryan C. Todd, Shuzhong Zhang, Michael S. McCormick, J. Alejandro D'Aquino, Joyce T. Reardon, Aziz Sancar, Kathleen M. Giacomini, and Stephen J. Lippard, Proc. Natl. Acad. Sci. U. S. A., 105, 8902-8907 (2008).
Bacterial Nitric-oxide Synthases Operate without a Dedicated Redox Partner. Ivan Gusarov, Marina Starodubtseva, Zhi-Qiang Wang, Lindsey McQuade, Stephen J. Lippard, Dennis J. Stuehr, and Evgeny Nudler, J. Biol. Chem., 283, 13140-13147 (2008).
Iron Complexes of Dendrimer-Appended Carboxylates for Activating Dioxygen and Oxidizing Hydrocarbons. Min Zhao, Brett Helms, Elena Slonkina, Simone Friedle, Dongwhan Lee, Jennifer DuBois, Britt Hedman, Keith O. Hodgson, Jean M. J. Fréchet, and Stephen J. Lippard, J. Am. Chem. Soc., 130, 4352-4363 (2008).
A 1,2-d(GpG) Cisplatin Intrastrand Cross-Link Influences the Rotational and Translational Setting of DNA in Nucleosomes. Matthias Ober and Stephen J. Lippard, J. Am. Chem. Soc., 130, 2851-2861 (2008).
Synthesis and characterization of a ditriflate-bridged, diiron(II) complex with syn-N-donor ligands: [Fe2(μ-OTf)2(PIC2DET)2](BARF)2. Jeremy J. Kodanko and Stephen J. Lippard, Inorg. Chim. Acta, 361, 894-900 (2008).
Bacillus anthracis-derived nitric oxide is essential for pathogen virulence and survival in macrophages. Konstantin Shatalin, Ivan Gusarov, Ekaterina Avetissova, Yelena Shatalina, Lindsey E. McQuade, Stephen J. Lippard, and Evgeny Nudler, Proc. Natl. Acad. Sci. U. S. A., 105, 1009-1013 (2008).
Conjugated Platinum(IV)–Peptide Complexes for Targeting Angiogenic Tumor Vasculature. Sumitra Mukhopadhyay, Carmen M. Barnés, Ariel Haskel, Sarah M. Short, Katie R. Barnes, and Stephen J. Lippard, Bioconjugate Chem., 19, 39-49 (2008).
A Reversible pH-Dependent Intramolecular Pyridine–Aldehyde Cyclization. Xiao-an Zhang, Datong Song, and Stephen J. Lippard, J. Org. Chem., 73, 734-737 (2008).
Synthesis of Dicarboxylate "C-Clamp" 1,2-Diethynylarene Compounds as Potential Transition-Metal Ion Hosts. Erwin Reisner and Stephen J. Lippard, Eur. J. Org. Chem., 2008, 156-163 (2008).
2007
Dioxygen Activation at Non-Heme Diiron Centers: Oxidation of a Proximal Residue in the I100W Variant of Toluene/o-Xylene Monooxygenase Hydroxylase. Leslie J. Murray, Ricardo García-Serres, Michael S. McCormick, Roman Davydov, Sunil G. Naik, Sun-Hee Kim, Brian M. Hoffman, Boi Hanh Huynh, and Stephen J. Lippard, Biochemistry, 46, 14795-14809 (2007).
A Planar Carboxylate-Rich Tetrairon(II) Complex and Its Conversion to Linear Triiron(II) and Paddlewheel Diiron(II) Complexes. Erwin Reisner, Joshua Telser, and Stephen J. Lippard, Inorg. Chem., 46, 10754-10770 (2007).
Characterization of the Arene-Oxidizing Intermediate in ToMOH as a Diiron(III) Species. Leslie J. Murray, Sunil G. Naik, Danilo O. Ortillo, Ricardo García-Serres, Jessica K. Lee, Boi Hanh Huynh, and Stephen J. Lippard, J. Am. Chem. Soc., 129, 14500-14510 (2007).
Influence of Steric Hindrance on the Core Geometry and Sulfoxidation Chemistry of Carboxylate-Rich Diiron(II) Complexes. Erwin Reisner, Tanya C. Abikoff, and Stephen J. Lippard, Inorg. Chem., 46, 10229-10240 (2007).
Reactivity pathways for nitric oxide and nitrosonium with iron complexes in biologically relevant sulfur coordination spheres. Todd C. Harrop, Datong Song, and Stephen J. Lippard, J. Inorg. Biochem., 101, 1730-1738 (2007).
Selective fluorescence detection of nitroxyl over nitric oxide in buffered aqueous solution using a conjugated metallopolymer. Andrew G. Tennyson, Loi Do, Rhett C. Smith, and Stephen J. Lippard, Polyhedron, 26, 4625-4630 (2007).
Electronic Structure and FeNO Conformation of Nonheme Iron–Thiolate–NO Complexes: An Experimental and DFT Study. Jeanet Conradie, Duncan A. Quarless, Jr., Hua-Fen Hsu, Todd C. Harrop, Stephen J. Lippard, Stephen A. Koch, and Abhik Ghosh, J. Am. Chem. Soc., 129, 10446-10456 (2007).
Substrate Trafficking and Dioxygen Activation in Bacterial Multicomponent Monooxygenases. Leslie J. Murray and Stephen J. Lippard, Acc. Chem. Res., 40, 466-474 (2007).
Soluble Single-Walled Carbon Nanotubes as Longboat Delivery Systems for Platinum(IV) Anticancer Drug Design. Rodney P. Feazell, Nozomi Nakayama-Ratchford, Hongjie Dai, and Stephen J. Lippard, J. Am. Chem. Soc., 129, 8438-8439 (2007).
Synthesis, Structure, and Properties of a Mixed-Valent Triiron Complex of Tetramethyl Reductic Acid, an Ascorbic Acid Analogue, and Its Relationship to a Functional Non-Heme Iron Oxidation Catalyst System. YooJin Kim, Xudong Feng, and Stephen J. Lippard, Inorg. Chem., 46, 6099-6107 (2007).
Water-soluble porphyrins as a dual-function molecular imaging platform for MRI and fluorescence zinc sensing. Xiao-an Zhang, Katherine S. Lovejoy, Alan Jasanoff, and Stephen J. Lippard, Proc. Natl. Acad. Sci. U. S. A., 104, 10780-10785 (2007).
Direct Cellular Responses to Platinum-Induced DNA Damage. Yongwon Jung and Stephen J. Lippard, Chem. Rev., 107, 1387-1407 (2007).
Understanding the Effect of Carbonate Ion on Cisplatin Binding to DNA. Ryan C. Todd, Katherine S. Lovejoy, and Stephen J. Lippard, J. Am. Chem. Soc., 129, 6370-6371 (2007).
Cisplatin Damage Overrides the Predefined Rotational Setting of Positioned Nucleosomes. Matthias Ober and Stephen J. Lippard, J. Am. Chem. Soc., 129, 6278-6286 (2007).
Turn-On and Ratiometric Mercury Sensing in Water with a Red-Emitting Probe. Elizabeth M. Nolan and Stephen J. Lippard, J. Am. Chem. Soc., 129, 5910-5918 (2007).
Frank Albert Cotton (1930–2007). Stephen J. Lippard, Nature, 446, 626 (2007).
Bifunctional Binding of Cisplatin to DNA: Why Does Cisplatin Form 1,2-Intrastrand Crosslinks with AG But Not with GA? Yogita Mantri, Stephen J. Lippard, and Mu-Hyun Baik, J. Am. Chem. Soc., 129, 5023-5030 (2007).
Intermediates in Dioxygen Activation by Methane Monooxygenase: A QM/MM Study. David Rinaldo, Dean M. Philipp, Stephen J. Lippard, and Richard A. Friesner, J. Am. Chem. Soc., 129, 3135-3147 (2007).
Products from Enzyme-Catalyzed Oxidations of Norcarenes. Martin Newcomb, Dharmika S. P. Lansakara-P., Hye-Yeong Kim, R. Esala P. Chandrasena, Stephen J. Lippard, Laurance G. Beauvais, Leslie J. Murray, Viviana Izzo, Paul F. Hollenberg, and Minor J. Coon, J. Org. Chem., 72, 1128-1133 (2007).
Desaturase Reactions Complicate the Use of Norcarane as a Mechanistic Probe. Unraveling the Mixture of Twenty-Plus Products Formed in Enzyme-Catalyzed Oxidations of Norcarane. Martin Newcomb, R. Esala P. Chandrasena, Dharmika S. P. Lansakara-P., Hye-Yeong Kim, Stephen J. Lippard, Laurance G. Beauvais, Leslie J. Murray, Viviana Izzo, Paul F. Hollenberg, and Minor J. Coon, J. Org. Chem., 72, 1121-1127 (2007).
Metal-Based Turn-On Fluorescent Probes for Sensing Nitric Oxide. Mi Hee Lim and Stephen J. Lippard, Acct. Chem. Res., 40, 41-51 (2007).
2006
X-Ray Structure of a Hydroxylase-Regulatory Protein Complex from a Hydrocarbon-Oxidizing Multicomponent Monooxygenase, Pseudomonas sp. OX1 Phenol Hydroxylase. Matthew H. Sazinsky, Pete W. Dunten, Michael S. McCormick, Alberto DiDonato, and Stephen J. Lippard, Biochemistry, 45, 15392-15404 (2006).
Zinspy Sensors with Enhanced Dynamic Range for Imaging Neuronal Cell Zinc Uptake and Mobilization. Elizabeth M. Nolan, Jubin W. Ryu, Jacek Jaworski, Rodney P. Feazell, Morgan Sheng, and Stephen J. Lippard, J. Am. Chem. Soc., 128, 15517-15528 (2006).
X-ray Crystal Structures of Manganese(II)-Reconstituted and Native Toluene/o-xylene Monooxygenase Hydroxylase Reveal Rotamer Shifts in Conserved Residues and an Enhanced View of the Protein Interior. Michael S. McCormick, Matthew H. Sazinsky, Karen L. Condon, and Stephen J. Lippard, J. Am. Chem. Soc., 128, 15108-15110 (2006).
Midrange Affinity Fluorescent Zn(II) Sensors of the Zinpyr Family: Syntheses, Characterization, and Biological Imaging Applications. Elizabeth M. Nolan, Jacek Jaworski, Maryann E. Racine, Morgan Sheng, and Stephen J. Lippard, Inorg. Chem., 45, 9748-9757 (2006).
Conjugated Metallopolymers for Fluorescent Turn-On Detection of Nitric Oxide. Rhett C. Smith, Andrew G. Tennyson, Annie C. Won, and Stephen J. Lippard, Inorg. Chem., 45, 9367-9373 (2006).
Luminescent Properties of Water-Soluble Conjugated Metallopolymers and Their Application to Fluorescent Nitric Oxide Detection. Loi Do, Rhett C. Smith, Andrew G. Tennyson, and Stephen J. Lippard, Inorg. Chem., 45, 8998-9005 (2006).
Fluorescent Nitric Oxide Detection by Copper Complexes Bearing Anthracenyl and Dansyl Fluorophore Ligands. Mi Hee Lim and Stephen J. Lippard, Inorg. Chem., 45, 8980-8989 (2006).
Direct Nitric Oxide Detection In Aqueous Solution by Copper(II) Fluorescein Complexes. Mi Hee Lim, Brian A. Wong, William H. Pitcock, Jr., Deepa Mokshagundam, Mu-Hyun Baik, and Stephen J. Lippard, J. Am. Chem. Soc., 128, 14364-14373 (2006).
The inorganic side of chemical biology. Stephen J. Lippard, Nat. Chem. Biol., 2, 504-507 (2006).
Characterization of the Particulate Methane Monooxygenase Metal Centers in Multiple Redox States by X-ray Absorption Spectroscopy. Raquel L. Lieberman, Kalyan C. Kondapalli, Deepak B. Shrestha, Amanda S. Hakemian, Stephen M. Smith, Joshua Telser, Jane Kuzelka, Rajeev Gupta, A. S. Borovik, Stephen J. Lippard, Brian M. Hoffman, Amy C. Rosenzweig, and Timothy L. Stemmler, Inorg. Chem., 45, 8372-8381 (2006).
Nitric Oxide-Induced Fluorescence Enhancement by Displacement of Dansylated Ligands from Cobalt. Mi Hee Lim, Chaoyuan Kuang, and Stephen J. Lippard, ChemBioChem, 7, 1571-1576 (2006).
Organic Cation Transporters Are Determinants of Oxaliplatin Cytotoxicity. Shuzhong Zhang, Katherine S. Lovejoy, James E. Shima, Leah L. Lagpacan, Yan Shu, Anna Lapuk, Ying Chen, Takafumi Komori, Joe W. Gray, Xin Chen, Stephen J. Lippard, and Kathleen M. Giacomini, Cancer Research, 66, 8847-8857 (2006).
Correlating Structure with Function in Bacterial Multicomponent Monooxygenases and Related Diiron Proteins. Matthew H. Sazinsky and Stephen J. Lippard, Acct. Chem. Res., 39, 558-566 (2006).
Analogues of Zinpyr-1 Provide Insight into the Mechanism of Zinc Sensing. Christian R. Goldsmith and Stephen J. Lippard, Inorg. Chem., 45, 6474-6478 (2006).
Water Induces a Structural Conversion and Accelerates the Oxygenation of Carboxylate-Bridged Non-Heme Diiron Enzyme Synthetic Analogues. Min Zhao, Datong Song, and Stephen J. Lippard, Inorg. Chem., 45, 6323-6330 (2006).
Polymer-Bound Dirhodium Tetracarboxylate Films for Fluorescent Detection of Nitric Oxide. Rhett C. Smith, Andrew G. Tennyson, and Stephen J. Lippard, Inorg. Chem., 45, 6222-6226 (2006).
Mechanistic Studies of the Oxidative N-Dealkylation of a Substrate Tethered to Carboxylate-Bridged Diiron(II) Complexes, [Fe2(μ-O2CArTol)2(O2CArTol)2(N,N-Bn2en)2]. Sungho Yoon and Stephen J. Lippard, Inorg. Chem., 45, 5438-5446 (2006).
Visualization of Nitric Oxide in Living Cells by a Copper-Based Fluorescent Probe. Mi Hee Lim, Dong Xu, and Stephen J. Lippard, Nat. Chem. Biol., 2, 375-380 (2006).
Dioxygen Activation at Non-Heme Diiron Centers: Characterization of Intermediates in a Mutant Form of Toluene/o-Xylene Monooxygenase Hydroxylase. Leslie J. Murray, Ricardo García-Serres, Sunil Naik, Boi Hanh Huynh, and Stephen J. Lippard, J. Am. Chem. Soc., 128, 7458-7459 (2006).
Synthesis and oxidation of carboxylate-bridged diiron(II) complexes with substrates tethered to primary alkyl amine ligands. Emily C. Carson and Stephen J. Lippard, J. Inorg. Biochem., 100, 1109-1117 (2006).
Zinc Metalloneurochemistry: Physiology, Pathology, and Probes. Christopher J. Chang and Stephen J. Lippard, Met. Ions Life Sci., 1, 321-370 (2006).
Interaction of Nitric Oxide with Tetrathiolato Iron(II) Complexes: Relevance to the Reaction Pathways of Iron Nitrosyls in Sulfur-Rich Biological Coordination Environments. Todd C. Harrop, Datong Song, and Stephen J. Lippard, J. Am. Chem. Soc., 128, 3528-3529 (2006).
Selective Hg(II) Detection in Aqueous Solution with Thiol Derivatized Fluoresceins. Elizabeth M. Nolan, Maryann E. Racine, and Stephen J. Lippard, Inorg. Chem., 45, 2742-2749 (2006).
Zinc-secreting Paneth Cells Studied by ZP Fluorescence. Leonard J. Giblin, Christopher J. Chang, Anthony F. Bentley, Cathleen Frederickson, Stephen J. Lippard, and Christopher J. Frederickson, J. Histochem. Cytochem., 54, 311-316 (2006).
RNA Polymerase II Blockage by Cisplatin-damaged DNA: Stability and Polyubiquitylation of Stalled Polymerase. Yongwon Jung and Stephen J. Lippard, J. Biol. Chem., 281, 1361-1370 (2006).
Selective Labeling of Extracellular Proteins Containing Polyhistidine Sequences by a Fluorescein-Nitrilotriacetic Acid Conjugate. Christian R. Goldsmith, Jacek Jaworski, Morgan Sheng, and Stephen J. Lippard, J. Am. Chem. Soc., 128, 418-419 (2006).
Dioxygen-Initiated Oxidation of Heteroatomic Substrates Incorporated into Ancillary Pyridine Ligands of Carboxylate-Rich Diiron(II) Complexes. Emily C. Carson and Stephen J. Lippard, Inorg. Chem., 45, 837-848 (2006).
Synthesis, Characterization, and Preliminary Oxygenation Studies of Benzyl- and Ethyl-Substituted Pyridine Ligands of Carboxylate-Rich Diiron(II) Complexes. Emily C. Carson and Stephen J. Lippard, Inorg. Chem., 45, 828-836 (2006).
6-Methylpyridyl for Pyridyl Substitution Tunes the Properties of Fluorescent Zinc Sensors of the Zinpyr Family. Christian R. Goldsmith and Stephen J. Lippard, Inorg. Chem., 45, 555-561 (2006).
2005
Structural Aspects of Pt-DNA Adduct Recognition by Proteins. Uta-Maria Ohndorf and Stephen J. Lippard, In: DNA Damage Recognition, Wolfram Siede, Yoke Wah Kow, Paul W. Doetsch, Eds., CRC Press: Boca Raton, FL, 12, 239-261 (2005).
Intermolecular Electron-Transfer Reactions in Soluble Methane Monooxygenase: A Role for Hysteresis in Protein Function. Jessica L. Blazyk, George T. Gassner, and Stephen J. Lippard, J. Am. Chem. Soc., 127, 17364-17376 (2005).
QZ1 and QZ2: Rapid, Reversible Quinoline-Derivatized Fluoresceins for Sensing Biological Zn(II). Elizabeth M. Nolan, Jacek Jaworski, Ken-Ichi Okamoto, Yasunori Hayashi, Morgan Sheng, and Stephen J. Lippard, J. Am. Chem. Soc., 127, 16812-16823 (2005).
Iron Substitution for Sodium in a Carboxylate-Bridged, Heterodinuclear Sodium–Iron Complex. Jeremy J. Kodanko, Dong Xu, Datong Song, and Stephen J. Lippard, J. Am. Chem. Soc., 127, 16004-16005 (2005).
Reactions of the diiron(IV) intermediate Q in soluble methane monooxygenase with fluoromethanes. Laurance G. Beauvais and Stephen J. Lippard, Biochem. Biophys. Res. Commun., 338, 262-266 (2005).
Conjugated Polymer-Based Fluorescence Turn-On Sensor for Nitric Oxide. Rhett C. Smith, Andrew G. Tennyson, Mi Hee Lim, and Stephen J. Lippard, Org. Lett., 7, 3573-3575 (2005).
Synthesis of Diethynyltriptycene-Linked Dipyridyl Ligands. Jeremy J. Kodanko, Anna J. Morys, and Stephen J. Lippard, Org. Lett., 7, 4585-4588 (2005).
Metal Ion Chemistry for Sustaining Life. Stephen J. Lippard, In: Medicinal Inorganic Chemistry, Jonathan L. Sessler, Susan R. Doctrow, Thomas J. McMurry, Stephen J. Lippard, Eds., ACS Symp. Ser., 903, 1-3 (2005).
Copper Complexes for Fluorescence-Based NO Detection in Aqueous Solution. Mi Hee Lim and Stephen J. Lippard, J. Am. Chem. Soc., 127, 12170-12171 (2005).
Platinum anticancer drug damage enforces a particular rotational setting of DNA in nucleosomes. Andrew Danford, Dong Wang, Qun Wang, Thomas D. Tullius, and Stephen J. Lippard, Proc. Natl. Acad. Sci. U. S. A., 102, 12311-12316 (2005).
MS4, a seminaphthofluorescein-based chemosensor for the ratiometric detection of Hg(II). Elizabeth M. Nolan and Stephen J. Lippard, J. Mat. Chem., 15, 2778-2783 (2005).
Fluorescence-Based Nitric Oxide Detection. Scott A. Hilderbrand, Mi Hee Lim, and Stephen J. Lippard, In: Topics in Fluorescence Spectroscopy Advanced Concepts in Fluorescence Sensing Part A: Small Molecule Sensing, Chris D. Geddes, Joseph R. Lakowicz, Eds., Springer: New York, 9, 163-188 (2005).
Esterase-Activated Two-Fluorophore System for Ratiometric Sensing of Biological Zinc(II). Carolyn C. Woodroofe, Annie C. Won, and Stephen J. Lippard, Inorg. Chem., 44, 3112-3120 (2005).
X-Ray Absorption Spectroscopic Study of the Reduced Hydroxylases of Methane Monooxygenase and Toluene/o-Xylene Monooxygenase: Differences in Active Site Structure and Effects of the Coupling Proteins MMOB and ToMOD. Deanne Jackson Rudd, Matthew H. Sazinsky, Stephen J. Lippard, Britt Hedman, and Keith O. Hodgson, Inorg. Chem., 44, 4546-4554 (2005).
Water Affects the Stereochemistry and Dioxygen Reactivity of Carboxylate-Rich Diiron(II) Models for the Diiron Centers in Dioxygen-Dependent Non-Heme Enzymes. Sungho Yoon and Stephen J. Lippard, J. Am. Chem. Soc., 127, 8386-8397 (2005).
Hydroxylation of C–H bonds at carboxylate-bridged diiron centres. Stephen J. Lippard, Phil. Trans. R. Soc. A, 363, 861-877 (2005).
Reactions of the Peroxo Intermediate of Soluble Methane Monooxygenase Hydroxylase with Ethers. Laurance G. Beauvais and Stephen J. Lippard, J. Am. Chem. Soc., 127, 7370-7378 (2005).
Product Bound Structures of the Soluble Methane Monooxygenase Hydroxylase from Methylococcus capsulatus (Bath): Protein Motion in the α-Subunit. Matthew H. Sazinsky and Stephen J. Lippard, J. Am. Chem. Soc., 127, 5814-5825 (2005).
Fourier Transform Infrared Characterization of the Azido Complex of Methane Monooxygenase Hydroxylase from Methylococcus capsulatus (Bath). Shen Lu, Matthew H. Sazinsky, James W. Whittaker, Stephen J. Lippard, and Pierre Moënne-Loccoz, J. Am. Chem. Soc., 127, 4148-4149 (2005).
Cellular Processing of Platinum Anticancer Drugs. Dong Wang and Stephen J. Lippard, Nat. Rev. Drug. Disc., 4, 307-320 (2005).
Synthesis of isomerically pure carboxylate- and sulfonate-substituted xanthene fluorophores. Carolyn C. Woodroofe, Mi Hee Lim, Weiming Bu, and Stephen J. Lippard, Tetrahedron, 61, 3097-3105 (2005).
Substrate Hydroxylation in Methane Monooxygenase: Quantitative Modeling via Mixed Quantum Mechanics/Molecular Mechanics Techniques. Benjamin F. Gherman, Stephen J. Lippard, and Richard A. Friesner, J. Am. Chem. Soc., 127, 1025-1037 (2005).
Synthesis of a constrained ligand comprising carboxylate and amine donor groups via direct 1,8-functionalization of positionally protected fluorene. Dirk Burdinski, Karen Cheng, and Stephen J. Lippard, Tetrahedron, 61, 1587-1594 (2005).
2004
Membrane-Permeable and -Impermeable Sensors of the Zinpyr Family and Their Application to Imaging of Hippocampal Zinc in Vivo. Carolyn C. Woodroofe, Rafik Masalha, Katie R. Barnes, Christopher J. Frederickson, and Stephen J. Lippard, Chem. Biol., 11, 1659-1666 (2004).
Preparation and X-ray Structures of Metal-Free, Dicobalt and Dimanganese Forms of Soluble Methane Monooxygenase Hydroxylase from Methylococus capsulatus (Bath). Matthew H. Sazinsky, Maarten Merkx, Elisabeth Cadieux, Sonya Tang, and Stephen J. Lippard, Biochemistry, 43, 16263-16276 (2004).
The Zinspy Family of Fluorescent Zinc Sensors: Syntheses and Spectroscopic Investigations. Elizabeth M. Nolan and Stephen J. Lippard, Inorg. Chem., 43, 8310-8317 (2004).
Water-Dependent Reactions of Diiron(II) Carboxylate Complexes. Sungho Yoon and Stephen J. Lippard, J. Am. Chem. Soc., 126, 16692-16693 (2004).
Di- and tetra-bridged diiron(II) complexes with four terphenyl-derived carboxylates and two water molecules. Sungho Yoon, Amy E. Kelly, and Stephen J. Lippard, Polyhedron, 23, 2805-2812 (2004).
ZP8, a Neuronal Zinc Sensor with Improved Dynamic Range; Imaging Zinc in Hippocampal Slices with Two-Photon Microscopy. Christopher J. Chang, Elizabeth M. Nolan, Jacek Jaworski, Ken-Ichi Okamoto, Yasunori Hayashi, Morgan Sheng, and Stephen J. Lippard, Inorg. Chem., 43, 6774-6779 (2004).
Fluorescence-Based Nitric Oxide Detection by Ruthenium Porphyrin Fluorophore Complexes. Mi Hee Lim and Stephen J. Lippard, Inorg. Chem., 43, 6366-6370 (2004).
NMR Structure of the Flavin Domain from Soluble Methane Monooxygenase Reductase from Methylococcus capsulatus (Bath). Lisa L. Chatwood, Jens Müller, John D. Gross, Gerhard Wagner, and Stephen J. Lippard, Biochemistry, 43, 11983-11991 (2004).
Synthesis of fluorescein derivatives containing metal-coordinating heterocycles. Matthew A. Clark, Scott A. Hilderbrand, and Stephen J. Lippard, Tetrahedron Lett., 45, 7129-7131 (2004).
Method for identifying neuronal cells suffering zinc toxicity by use of a novel fluorescent sensor. Christopher J. Frederickson, Shawn C. Burdette, Cathy J. Frederickson, Stefano L. Sensi, John H. Weiss, Hong Z. Yin, Rengarajan V. Balaji, Ai Q. Truong-Tran, Eric Bedell, Donald S. Prough, and Stephen J. Lippard, J. Neurosci. Meth., 139, 79-89 (2004).
Nitric Oxide Reactivity of Fluorophore Coordinated Carboxylate-Bridged Diiron(II) and Dicobalt(II) Complexes. Scott A. Hilderbrand and Stephen J. Lippard, Inorg. Chem., 43, 5294-5301 (2004).
Cobalt Chemistry with Mixed Aminotroponiminate Salicylaldiminate Ligands: Synthesis, Characterization, and Nitric Oxide Reactivity. Scott A. Hilderbrand and Stephen J. Lippard, Inorg. Chem., 43, 4674-4682 (2004).
Determination by X-ray Absorption Spectroscopy of the Fe–Fe Separation in the Oxidized Form of the Hydroxylase of Methane Monooxygenase Alone and in the Presence of MMOD. Deanne Jackson Rudd, Matthew H. Sazinsky, Maarten Merkx, Stephen J. Lippard, Britt Hedman, and Keith O. Hodgson, Inorg. Chem., 43, 4579-4589 (2004).
Catalytic Oxidative Ring Opening of THF Promoted by a Carboxylate-Bridged Diiron Complex, Triarylphosphines, and Dioxygen. Rayane F. Moreira, Edit Y. Tshuva, and Stephen J. Lippard, Inorg. Chem., 43, 4427-4434 (2004).
Crystal Structure of the Toluene/o-Xylene Monooxygenase Hydroxylase from Pseudomonas stutzeri OX1. Matthew H. Sazinsky, Joel Bard, Alberto Di Donato, and Stephen J. Lippard, J. Biol. Chem., 279, 30600-30610 (2004).
Identification of Nuclear Proteins that Interact with Platinum-Modified DNA by Photoaffinity Labeling. Christiana Xin Zhang, Pamela V. Chang, and Stephen J. Lippard, J. Am. Chem. Soc., 126, 6536-6537 (2004).
Cisplatin-induced Post-translational Modification of Histones H3 and H4. Dong Wang and Stephen J. Lippard, J. Biol. Chem., 279, 20622-20625 (2004).
Bioinorganic chemistry: Editorial overview. Jeremy M. Berg and Stephen J. Lippard, Curr. Opin. Chem. Biol., 8, 160-161 (2004).
Synthesis, Characterization, and Cytotoxicity of a Series of Estrogen-Tethered Platinum(IV) Complexes. Katie R. Barnes, Alexander Kutikov, and Stephen J. Lippard, Chem. Biol., 11, 557-564 (2004).
Dirhodium Tetracarboxylate Scaffolds as Reversible Fluorescence-Based Nitric Oxide Sensors. Scott A. Hilderbrand, Mi Hee Lim, and Stephen J. Lippard, J. Am. Chem. Soc., 126, 4972-4978 (2004).
Synthesis and Characterization of Zinc Sensors Based on a Monosubstituted Fluorescein Platform. Elizabeth M. Nolan, Shawn C. Burdette, Jessica H. Harvey, Scott A. Hilderbrand, and Stephen J. Lippard, Inorg. Chem., 43, 2624-2635 (2004).
Cisplatin and Related Anticancer Drugs: Recent Advances and Insights. Katie R. Barnes and Stephen J. Lippard, In: Metal Ions in Biological Systems: Metal Complexes in Tumor Diagnosis and as Anticancer Agents, Astrid Sigel and Helmut Sigel, Eds., Marcel Dekker: New York, 42, 143-177 (2004).
Oxidation of Sulfide, Phosphine, and Benzyl Substrates Tethered to N-Donor Pyridine Ligands in Carboxylate-Bridged Diiron(II) Complexes. Emily C. Carson and Stephen J. Lippard, J. Am. Chem. Soc., 126, 3412-3413 (2004).
Synthesis and Characterization of Cu2(I,I), Cu2(I,II), and Cu2(II,II) Compounds Supported by Two Phthalazine-Based Ligands: Influence of a Hydrophobic Pocket. Jane Kuzelka, Sumitra Mukhopadhyay, Bernhard Spingler, and Stephen J. Lippard, Inorg. Chem., 43, 1751-1761 (2004).
Dioxygen Activation in Methane Monooxygenase: A Theoretical Study. Benjamin F. Gherman, Mu-Hyun Baik, Stephen J. Lippard, and Richard A. Friesner, J. Am. Chem. Soc., 126, 2978-2990 (2004).
Synthesis and Characterization of Carboxylate-Rich Complexes Having the {Fe2(μ-OH)2(μ-O2CR)}3+ and {Fe2(μ-O)(μ-O2CR)}3+ Cores of O2-Dependent Diiron Enzymes. Sungho Yoon and Stephen J. Lippard, J. Am. Chem. Soc., 126, 2666-2667 (2004).
Bright Fluorescent Chemosensor Platforms for Imaging Endogenous Pools of Neuronal Zinc. Christopher J. Chang, Elizabeth M. Nolan, Jacek Jaworski, Shawn C. Burdette, Morgan Sheng, and Stephen J. Lippard, Chem. Biol., 11, 203-210 (2004).
Synthetic Models for Non-Heme Carboxylate-Bridged Diiron Metalloproteins: Strategies and Tactics. Edit Y. Tshuva and Stephen J. Lippard, Chem. Rev., 104, 987-1012 (2004).
Domain Engineering of the Reductase Component of Soluble Methane Monooxygenase from Methylococcus capsulatus (Bath). Jessica L. Blazyk and Stephen J. Lippard, J. Biol. Chem., 279, 5630-5640 (2004).
A tautomeric zinc sensor for ratiometric fluorescence imaging: Application to nitric oxide-induced release of intracellular zinc. Christopher J. Chang, Jacek Jaworski, Elizabeth M. Nolan, Morgan Sheng, and Stephen J. Lippard, Proc. Natl. Acad. Sci. U. S. A., 101, 1129-1134 (2004).
2003
Modeling the Syn Disposition of Nitrogen Donors at the Active Sites of Carboxylate-Bridged Diiron Enzymes. Enforcing Dinuclearity and Kinetic Stability with a 1,2-Diethynylbenzene-Based Ligand. Jane Kuzelka, Joshua R. Farrell, and Stephen J. Lippard, Inorg. Chem., 42, 8652-8662 (2003).
cis-[Pt(NH3)2(L)]2+/+ (L = Cl, H2O, NH3) Binding to Purines and CO: Does π-Back-Donation Play a Role? Mu-Hyun Baik, Richard A. Friesner, and Stephen J. Lippard, Inorg. Chem., 42, 8615-8617 (2003).
Synthesis, Characterization, and Dioxygen Reactivity of Tetracarboxylate-Bridged Diiron(II) Complexes with Coordinated Substrates. Sungho Yoon and Stephen J. Lippard, Inorg. Chem., 42, 8606-8608 (2003).
Multiple States of Stalled T7 RNA Polymerase at DNA Lesions Generated by Platinum Anticancer Agents. Yongwon Jung and Stephen J. Lippard, J. Biol. Chem., 278, 52084-52092 (2003).
Nonheme Di-iron Enzymes. Dongwhan Lee and Stephen J. Lippard, In: Comprehensive Coordination Chemistry II, Lawrence Que, Jr. and William B. Tolman, Eds., Pergamon Press: Oxford, 8, 309-342 (2003).
A “Turn-On” Fluorescent Sensor for the Selective Detection of Mercuric Ion in Aqueous Media. Elizabeth M. Nolan and Stephen J. Lippard, J. Am. Chem. Soc., 125, 14270-14271 (2003).
Theoretical Study of Cisplatin Binding to Purine Bases: Why Does Cisplatin Prefer Guanine over Adenine? Mu-Hyun Baik, Richard A. Friesner, and Stephen J. Lippard, J. Am. Chem. Soc., 125, 14082-14092 (2003).
Modeling Features of the Non-Heme Diiron Cores in O2-Activating Enzymes through the Synthesis, Characterization, and Oxidation of 1,8-Naphthyridine-Based Complexes. Jane Kuzelka, Sumitra Mukhopadhyay, Bernhard Spingler, and Stephen J. Lippard, Inorg. Chem., 42, 6447-6457 (2003).
A Novel Two-Fluorophore Approach to Ratiometric Sensing of Zn2+. Carolyn C. Woodroofe and Stephen J. Lippard, J. Am. Chem. Soc., 125, 11458-11459 (2003).
Stopped-Flow Fourier Transform Infrared Spectroscopy of Nitromethane Oxidation by the Diiron(IV) Intermediate of Methane Monooxygenase. Mylrajan Muthusamy, Edna A. Ambundo, Simon J. George, Stephen J. Lippard, and Roger N. F. Thorneley, J. Am. Chem. Soc., 125, 11150-11151 (2003).
New metal complexes as potential therapeutics. Christiana Xin Zhang and Stephen J. Lippard, Curr. Opin. Chem. Biol., 7, 481-489 (2003).
Mechanistic Studies on the Hydroxylation of Methane by Methane Monooxygenase. Mu-Hyun Baik, Martin Newcomb, Richard A. Friesner, and Stephen J. Lippard, Chem. Rev., 103, 2385-2420 (2003).
Peripheral heme substituents control the hydrogen-atom abstraction chemistry in cytochromes P450. Victor Guallar, Mu-Hyun Baik, Stephen J. Lippard, and Richard A. Friesner, Proc. Natl. Acad. Sci. U. S. A., 100, 6998-7002 (2003).
Structural Features of Covalently Cross-linked Hydroxylase and Reductase Proteins of Soluble Methane Monooxygenase as Revealed by Mass Spectrometric Analysis. Daniel A. Kopp, Eric A. Berg, Catherine E. Costello, and Stephen J. Lippard, J. Biol. Chem., 278, 20939-20945 (2003).
Nucleotide Excision Repair from Site-Specifically Platinum-Modified Nucleosomes. Dong Wang, Ryujiro Hara, Gitanjali Singh, Aziz Sancar, and Stephen J. Lippard, Biochemistry, 42, 6747-6753 (2003).
Synthesis and Metal-Binding Properties of Chelating Fluorescein Derivatives. Matthew A. Clark, Kathryn Duffy, Jyoti Tibrewala, and Stephen J. Lippard, Org. Lett., 5, 2051-2054 (2003).
How iron-containing proteins control dioxygen chemistry: a detailed atomic level description via accurate quantum chemical and mixed quantum mechanics/molecular mechanics calculations. Richard A. Friesner, Mu-Hyun Baik, Benjamin F. Gherman, Victor Guallar, Maria Wirstam, Robert B. Murphy, and Stephen J. Lippard, Coord. Chem. Rev., 238-239, 267-290 (2003).
Meeting of the minds: Metalloneurochemistry. Shawn C. Burdette and Stephen J. Lippard, Proc. Natl. Acad. Sci. U. S. A., 100, 3605-3610 (2003).
Reversible Dioxygen Binding to Hemerythrin. Maria Wirstam, Stephen J. Lippard, and Richard A. Friesner, J. Am. Chem. Soc., 125, 3980-3987 (2003).
Preparation of macrocyclic and 'C-clamp' dicarboxylate compounds. Joshua R. Farrell, Dylan Stiles, Weiming Bu, and Stephen J. Lippard, Tetrahedron, 59, 2463-2469 (2003).
Nature of Full-Length HMGB1 Binding to Cisplatin-Modified DNA. Yongwon Jung and Stephen J. Lippard, Biochemistry, 42, 2664-2671 (2003).
Zinc-Bound Thiolate-Disulfide Exchange: A Strategy for Inhibiting Metallo-β-Lactamases. Heidi Boerzel, Margery Koeckert, Weiming Bu, Bernhard Spingler, and Stephen J. Lippard, Inorg. Chem., 42, 1604-1615 (2003).
ZP4, an Improved Neuronal Zn2+ Sensor of the Zinpyr Family. Shawn C. Burdette, Christopher J. Frederickson, Weiming Bu, and Stephen J. Lippard, J. Am. Chem. Soc., 125, 1778-1787 (2003).
Cisplatin Sensitivity in Hmgb1-/- and Hmgb1+/+ Mouse Cells. Min Wei, Olga Burenkova, and Stephen J. Lippard, J. Biol. Chem., 278, 1769-1773 (2003).
2002
2.4-Å Crystal Structure of the Asymmetric Platinum Complex {Pt(ammine)(cyclohexylamine)}2+ Bound to a Dodecamer DNA Duplex. Adam P. Silverman, Weiming Bu, Seth M. Cohen, and Stephen J. Lippard, J. Biol. Chem., 277, 49743-49749 (2002).
Expression and Characterization of Ferredoxin and Flavin Adenine Dinucleotide Binding Domains of the Reductase Component of Soluble Methane Monooxygenase from Methylococcus capsulatus (Bath). Jessica L. Blazyk and Stephen J. Lippard, Biochemistry, 41, 15780-15794 (2002).
The Rhodafluor Family. An Initial Study of Potential Ratiometric Fluorescent Sensors for Zn2+. Shawn C. Burdette and Stephen J. Lippard, Inorg. Chem., 41, 6816-6823 (2002).
Hydroxylation of Methane by Non-Heme Diiron Enzymes. Molecular Orbital Analysis of C–H Bond Activation by Reactive Intermediate Q. Mu-Hyun Baik, Benjamin F. Gherman, Richard A. Friesner, and Stephen J. Lippard, J. Am. Chem. Soc., 124, 14608-14615 (2002).
Structural flexibility within a sterically hindered ligand platform: mononuclear iron(II) carboxylate complexes as subsite models for diiron(II) centers. Donghwan Lee and Stephen J. Lippard, Inorg. Chim. Acta, 341, 1-11 (2002).
Component B Binding to the Soluble Methane Monooxygenase Hydroxylase by Saturation-Recovery EPR Spectroscopy of Spin-Labeled MMOB. Ryan MacArthur, Matthew H. Sazinsky, Henriette Kühne, Douglas A. Whittington, Stephen J. Lippard, and Gary W. Brudvig, J. Am. Chem. Soc., 124, 13392-13393 (2002).
Carboxylate-bridged diiron(II) complexes with a sterically hindered phthalazine ligand. Jane Kuzelka, Bernhard Spingler, and Stephen J. Lippard, Inorg. Chim. Acta, 337, 212-222 (2002).
Soluble methane monooxygenase: activation of dioxygen and methane. Daniel A. Kopp and Stephen J. Lippard, Curr. Opin. Chem. Biol., 6, 568-576 (2002).
Testis-specific HMG-domain protein alters the responses of cells to cisplatin. Deborah B. Zamble, Yuji Mikata, Christina H. Eng, Karen E. Sandman, and Stephen J. Lippard, J. Inorg. Biochem., 91, 451-462 (2002).
Theoretical Studies of Diiron(II) Complexes That Model Features of the Dioxygen-Activating Centers in Non-Heme Diiron Enzymes. Mu-Hyun Baik, Dongwhan Lee, Richard A. Friesner, and Stephen J. Lippard, Isr. J. Chem., 41, 173-186 (2002).
Reactions of Methane Monooxygenase Intermediate Q with Derivatized Methanes. Edna A. Ambundo, Richard A. Friesner, and Stephen J. Lippard, J. Am. Chem. Soc., 124, 8770-8771 (2002).
Evaluation of Norcarane as a Probe for Radicals in Cytochome P450- and Soluble Methane Monooxygenase-Catalyzed Hydroxylation Reactions. Martin Newcomb, Runnan Shen, Yun Lu, Minor J. Coon, Paul F. Hollenberg, Daniel A. Kopp, and Stephen J. Lippard, J. Am. Chem. Soc., 124, 6879-6886 (2002).
Structural and Spectroscopic Studies of Valence-Delocalized Diiron(II,III) Complexes Supported by Carboxylate-Only Bridging Ligands. Dongwhan Lee, Jennifer L. Dubois, Brad Pierce, Britt Hedman, Keith O. Hodgson, Michael P. Hendrich, and Stephen J. Lippard, Inorg. Chem., 41, 3172-3182 (2002).
Modeling Dioxygen-Activating Centers in Non-Heme Diiron Enzymes: Carboxylate Shifts in Diiron(II) Complexes Supported by Sterically Hindered Carboxylate Ligands. Dongwhan Lee and Stephen J. Lippard, Inorg. Chem., 41, 2704-2719 (2002).
Synthesis and Structure of [Fe13O4F24(OMe)12]5-: The First Open-Shell Keggin Ion. Avi Bino, Michael Ardon, Dongwhan Lee, Bernhard Spingler, and Stephen J. Lippard, J. Am. Chem. Soc., 124, 4578-4579 (2002).
Theoretical Study on the Stability of N-Glycosyl Bonds: Why Does N7-Platination not Promote Depurination? Mu-Hyun Baik, Richard A. Friesner, and Stephen J. Lippard, J. Am. Chem. Soc., 124, 4495-4503 (2002).
Transcription-coupled and DNA damage-dependent ubiquitination of RNA polymerase II in vitro. Keng-Boon Lee, Dong Wang, Stephen J. Lippard, and Philip A. Sharp, Proc. Nat. Acad. Sci. U. S. A., 99, 4239-4244 (2002).
Dynamics of Alkane Hydroxylation at the Non-heme Diiron Center in Methane Monooxygenase. Victor Guallar, Benjamin F. Gherman, William H. Miller, Stephen J. Lippard, and Richard A. Friesner, J. Am. Chem. Soc., 124, 3377-3384 (2002).
Quantum chemical studies of methane monooxygenase: comparision with P450. Victor Guallar, Benjamin F. Gherman, Stephen J. Lippard, and Richard A. Friesner, Curr. Opin. Chem. Biol., 6, 236-242 (2002).
The Art of Chemistry. Stephen J. Lippard, Nature, 416, 587 (2002).
Functional Mimic of Dioxygen-Activating Centers in Non-Heme Diiron Enzymes: Mechanistic Implications of Paramagnetic Intermediates in the Reactions between Diiron(II) Complexes and Dioxygen. Dongwhan Lee, Brad Pierce, Carsten Krebs, Michael P. Hendrich, Boi Hanh Huynh, and Stephen J. Lippard, J. Am. Chem. Soc., 124, 3993-4007 (2002).
Product Binding to the Diiron(III) and Mixed-Valence Diiron Centers of Methane Monooxygenase Hydroxylase Studied by 1,2H and 19F ENDOR Spectroscopy. Stoyan K. Smoukov, Daniel A. Kopp, Ann M. Valentine, Roman Davydov, Stephen J. Lippard, and Brian M. Hoffman. J. Am. Chem. Soc., 124, 2657-2663 (2002).
Catalytic Oxidation by a Carboxylate-Bridged Non-Heme Diiron Complex. Edit Y. Tshuva, Dongwhan Lee, Weiming Bu, and Stephen J. Lippard, J. Am. Chem. Soc., 124, 2416-2417 (2002).
Synthetic Analogue of the {Fe2(μ-OH)2(μ-O2CR)}3+ Core of Soluble Methane Monooxygenase Hydroxylase via Synthesis and Dioxygen Reactivity of Carboxylate-Bridged Diiron(II) Complexes. Dongwhan Lee and Stephen J. Lippard, Inorg. Chem., 41, 827-837 (2002).
Why OrfY? Characterization of MMOD, a Long Overlooked Component of the Soluble Methane Monooxygenase from Methylococcus capsulatus (Bath). Maarten Merkx and Stephen J. Lippard, J. Biol. Chem., 277, 5858-5865 (2002).
Sterically Hindered Carboxylate Ligands Support Water-Bridged Dimetallic Centers That Model Features of Metallohydrolase Active Sites. Donghwan Lee, Pei-Lin Hung, Bernhard Spingler, and Stephen J. Lippard, Inorg. Chem., 41, 521-531 (2002).
NMR Structure of the [2Fe-2S] Ferredoxin Domain from Soluble Methane Monooxygenase Reductase and Interaction with Its Hydroxylase. Jens Müller, Alexey A. Lugovskoy, Gerhard Wagner, and Stephen J. Lippard, Biochemistry, 41, 42-51 (2002).
2001
Hydroxo-Bridged Cubane-Type Tetrairon(II) Clusters Supported by Sterically-Hindered Carboxylate Ligands. Dongwhan Lee, Lorenzo Sorace, Andrea Caneschi, and Stephen J. Lippard, Inorg. Chem., 40, 6774-6781, (2001).
Electron-Transfer Reactions of the Reductase Component of Soluble Methane Monooxygenase from Methylococcus capsulatus (Bath). Daniel A. Kopp, George T. Gassner, Jessica L. Blazyk, and Stephen J. Lippard, Biochemistry, 40, 14932-14941 (2001).
Kinetic Studies of the TATA-binding Protein Interaction with Cisplatin-modified DNA. Yongwon Jung, Yuji Mikata, and Stephen J. Lippard, J. Biol. Chem., 276, 43589-43596 (2001).
Effects of Spectator Ligands on the Specific Recognition of Intrastrand Platinum-DNA Cross-links by High Mobility Group Box and TATA-binding Proteins. Min Wei, Seth M. Cohen, Adam P. Silverman, and Stephen J. Lippard, J. Biol. Chem., 276, 38774-38780 (2001).
2.4 Å Crystal Structure of an Oxaliplatin 1,2-d(GpG) Intrastrand Cross-link in a DNA Dodecamer Duplex. Bernhard Spingler, Douglas A. Whittington, and Stephen J. Lippard, Inorg. Chem., 40, 5596-5602 (2001).
Synthesis and Spectroscopic Studies of Non-Heme Diiron(III) Species with a Terminal Hydroperoxide Ligand: Models for Hemerythrin. Tadashi J. Mizoguchi, Jane Kuzelka, Bernhard Spingler, Jennifer L. Dubois, Roman M. Davydov, Britt Hedman, Keith O. Hodgson, and Stephen J. Lippard, Inorg. Chem., 40, 4662-4673 (2001).
Interchain hydrogen-bonding interactions may facilitate translocation of K+ ions across the potassium channel selectivity filter, as suggested by synthetic modeling chemistry. Juan C. Mareque Rivas, Harald Schwalbe, and Stephen J. Lippard, Proc. Natl. Acad. Sci. U. S. A., 98, 9478-9483 (2001).
Fluorescent Sensors for Zn2+ Based on a Fluorescein Platform: Synthesis, Properties and Intracellular Distribution. Shawn C. Burdette, Grant K. Walkup, Bernhard Spingler, Roger Y. Tsien, and Stephen J. Lippard, J. Am. Chem. Soc., 123, 7831-7841 (2001).
Dioxygen Activation and Methane Hydroxylation by Soluble Methane Monooxygenase: A Tale of Two Irons and Three Proteins. Maarten Merkx, Daniel A. Kopp, Matthew H. Sazinsky, Jessica L. Blazyk, Jens Müller, and Stephen J. Lippard, Angew. Chem., Int. Ed., 40, 2782-2807, (2001).
Cisplatin: From DNA Damage to Cancer Chemotherapy. Seth M. Cohen and Stephen J. Lippard, Progress in Nucelic Acids Research and Molecular Biology, 67, 93-130, (2001).
Trinuclear Zn(II) and Cu(II) Homo and Heterotrimetallic Complexes Involving D-Glucopyranosyl and Biscarboxylate Bridging Ligands. A Substrate Binding Model of Xylose Isomerases. Tomoaki Tanase, Hiromi Inukai, Tomoko Onaka, Merii Kato, Shigenobu Yano, and Stephen J. Lippard, Inorg. Chem., 40, 3943-3953 (2001).
Pentacoordinate Cobalt(III) Thiolate and Nitrosyl Tropocoronand Compounds. Katherine J. Franz, Linda H. Doerrer, Bernhard Spingler, and Stephen J. Lippard, Inorg. Chem., 40, 3774-3780 (2001).
Coordination chemistry for the neurosciences. Shawn C. Burdette and Stephen J. Lippard, Coord. Chem. Rev., 216-217, 333-361 (2001).
Intermediate in β-Lactam Hydrolysis Catalyzed by a Dinuclear Zinc(II) Complex: Relevance to the Mechanism of Metallo-β-lactamase. Natalia V. Kaminskaia, Bernhard Spingler, and Stephen J. Lippard, J. Am. Chem. Soc., 123, 6555-6563 (2001).
Interaction of FACT, SSRP1, and the High Mobility Group (HMG) Domain of SSRP1 with DNA Damaged by the Anticancer Drug Cisplatin. Amanda Yarnell, Sangtaek Oh, Danny Reinberg, and Stephen J. Lippard, J. Biol. Chem., 276, 25736-25741 (2001).
Laser-Induced Photo-Cross-Linking of Cisplatin-Modified DNA to HMG-Domain Proteins. Yuji Mikata, Qing He, and Stephen J. Lippard, Biochemistry, 40, 7533-7541 (2001).
Methane monooxygenase hydroxylase. Douglas A. Whittington and Stephen J. Lippard, In: Handbook of Metalloproteins, Albrecht Messerschmidt, Robert Huber, Thomas L. Poulos, and Karl Wieghardt, Eds., John Wiley & Sons Ltd.: Chichester, England, 712-724 (2001).
Oxidative N-Dealkylation of a Carboxylate-Bridged Diiron(II) Precursor Complex by Reaction with O2 Affords the Elusive {Fe2(μ-OH)2(μ-O2CR}3+ Core of Soluble Methane Monooxygenase Hydroxylase. Dongwhan Lee and Stephen J. Lippard, J. Am. Chem. Soc., 123, 4611-4612 (2001).
Activation of the C–H Bond of Methane by Intermediate Q of Methane Monooxygenase: A Theoretical Study. Benjamin F. Gherman, Barry D. Dunietz, Douglas A. Whittington, Stephen J. Lippard, and Richard A. Friesner, J. Am. Chem. Soc., 123, 3836-3837 (2001).
A Short Copper-Copper Distance in a (μ-1,2-Peroxo)dicopper(II) Complex Having a 1,8-Naphthyridine Unit as an Additional Bridge. Chuan He, Jennifer L. DuBois, Britt Hedman, Keith O. Hodgson, and Stephen J. Lippard, Angew. Chem., Int. Ed., 40, 1484-1487 (2001).
Synthesis and Electrochemical Studies of Diiron Complexes of 1,8-Naphthyridine-Based Dinucleating Ligands to Model Features of the Active Sites of Non-Heme Diiron Enzymes. Chuan He and Stephen J. Lippard, Inorg. Chem., 40, 1414-1420 (2001).
Xenon and Halogenated Alkanes Track Putative Substrate Binding Cavities in the Soluble Methane Monooxygenase Hydroxylase. Douglas A. Whittington, Amy C. Rosenzweig, Christin A. Frederick, and Stephen J. Lippard, Biochemistry, 40, 3476-3482 (2001).
Decomposition of Alkyl-Substitued Urea Molecules at a Hydroxide-Bridged Dinickel Center. Amy M. Barrios and Stephen J. Lippard, Inorg. Chem., 40, 1250-1255 (2001).
Oxygen Kinetic Isotope Effects in Soluble Methane Monooxygenase. Shannon S. Stahl, Wilson A. Francisco, Maarten Merkx, Judith P. Klinman, and Stephen J. Lippard, J. Biol. Chem., 276, 4549-4553 (2001).
X-ray Crystal Structure of Alcohol Products Bound at the Active Site of Soluble Methane Monooxygenase Hydroxylase. Douglas A. Whittington, Matthew H. Sazinsky, and Stephen J. Lippard, J. Am. Chem. Soc., 123, 1794-1795 (2001).
Crystal Structure Determination of a (μ-Amido)(μ-hydroxo)(μ-superoxo)dicobalt(III) Complex from the Werner Collection. Bernhard Spingler, Marie Scanavy-Grigorieff, Alfred Werner, Heinz Berke, and Stephen J. Lippard, Inorg. Chem., 40, 1065-1066 (2001).
Phthalazine-Based Dinucleating Ligands Afford Dinuclear Centers Often Encountered in Metalloenzyme Active Sites. Amy M. Barrios and Stephen J. Lippard, Inorg. Chem., 40, 1060-1064 (2001).
Crystal Structures of the Soluble Methane Monooxygenase Hydroxylase from Methylococcus capsulatus (Bath) Demonstrating Geometrical Variability at the Dinuclear Iron Active Site. Douglas A. Whittington and Stephen J. Lippard, J. Am. Chem. Soc., 123, 827-838 (2001).
2000
Diiron Complexes of 1,8-Naphthyridine-Based Dinucleating Ligands as Models for Hemerythrin. Chuan He, Amy M. Barrios, Dongwhan Lee, Jane Kuzelka, Roman M. Davydov, and Stephen J. Lippard, J. Am. Chem. Soc., 122, 12683-12690 (2000).
Intercalating Residues Determine the Mode of HMG1 Domains A and B Binding to Cisplatin-Modified DNA. Qing He, Uta-Maria Ohndorf, and Stephen J. Lippard, Biochemistry, 39, 14426-14435 (2000).
Synthesis and Characterization of Several Dicopper(I) Complexes and a Spin-Delocalized Dicopper(I,II) Mixed-Valence Complex Using a 1,8-Naphthyridine-Based Dinucleating Ligand. Chuan He and Stephen J. Lippard, Inorg. Chem., 39, 5225-5231 (2000).
High-throughput synthesis and screening of platinum drug candidates. Christopher J. Ziegler, Adam P. Silverman, and Stephen J. Lippard, J. Biol. Inorg. Chem., 5, 774-783 (2000).
Formation of cis-diamminedichloroplatinum(II) 1,2-intrastrand cross-links on DNA is flanking-sequence independent. Judith N. Burstyn, Wendy J. Heiger-Bernays, Seth M. Cohen, and Stephen J. Lippard, Nucleic Acids Res., 28, 4237-4243 (2000).
Design and Synthesis of Multidentate Dinucleating Ligands Based on 1,8-Naphthyridine. Chuan He and Stephen J. Lippard, Tetrahedron, 56, 8245-8252 (2000).
Mixed-Valent Heptairon Chloride Cluster Supported by the Porphyrin-Linked Dicarboxylate Ligand PDK. Xiao-Xiang Zhang and Stephen J. Lippard, Inorg. Chem., 39, 4388-4389 (2000).
Interaction of Urea with a Hydroxide-Bridged Dinuclear Nickel Center: An Alternative Model for the Mechanism of Urease. Amy M. Barrios and Stephen J. Lippard, J. Am. Chem. Soc., 122, 9172-9177 (2000).
Monodentate-Bridged Phosphodiester and Sulfate Complexes: Structural Insights into the Biological Activation of Phosphodiesters, Sulfate, and Sulfate Esters. Chuan He, Victoria Gomez, Bernhard Spingler, and Stephen J. Lippard, Inorg. Chem., 39, 4188-4189 (2000).
HMG-Domain Protein Recognition of Cisplatin 1,2-Intrastrand d(GpG) Cross-Links in Purine-Rich Sequence Contexts. Seth M. Cohen, Yuji Mikata, Qing He, and Stephen J. Lippard, Biochemistry, 39, 11771-11776 (2000).
Aminotroponiminates as Ligands for Potential Metal-Based Nitric Oxide Sensors. Katherine J. Franz, Nisha Singh, Bernhard Spingler, and Stephen J. Lippard, Inorg. Chem., 39, 4081-4092 (2000).
Understanding the dioxygen reaction chemistry of diiron proteins through synthetic modeling studies. J. Du Bois, Tadashi J. Mizoguchi, and Stephen J. Lippard, Coord. Chem. Rev., 200-202, 443-485 (2000).
Synthesis of PDK, a Novel Porphyrin-Linked Dicarboxylate Ligand. Xiao-Xiang Zhang and Stephen J. Lippard, J. Org. Chem., 65, 5298-5305 (2000).
The Quiet Revolution in Chemistry. Stephen J. Lippard, Chem. Eng. News, 78, 64-65 (2000).
Nitrosyl Transfer from Manganese to Iron in Tropocoronand Complexes. Katherine J. Franz and Stephen J. Lippard, Inorg. Chem., 39, 3722-3723 (2000).
Reactivity of μ-Hydroxodizinc(II) Centers in Enzymatic Catalysis through Model Studies. Natalia V. Kaminskaia, Chuan He, and Stephen J. Lippard, Inorg. Chem., 39, 3365-3373 (2000).
Stopped-Flow Fluorescence Studies of HMG-Domain Protein Binding to Cisplatin-Modified DNA. Elizabeth R. Jamieson and Stephen J. Lippard, Biochemistry, 39, 8426-8438 (2000).
Enhanced Binding of the TATA-Binding Protein to TATA Boxes Containing Flanking Cisplatin 1,2-Cross-Links. Seth M. Cohen, Elizabeth R. Jamieson, and Stephen J. Lippard, Biochemistry, 39, 8259-8265 (2000).
Hydrolysis of β-Lactam Antibiotics Catalyzed by Dinuclear Zinc(II) Complexes: Functional Mimics of Metallo-β-lactamases. Natalia V. Kaminskaia, Bernhard Spingler, and Stephen J. Lippard, J. Am. Chem. Soc., 122, 6411-6422 (2000).
Metal-Based NO Sensing by Selective Ligand Dissociation. Katherine J. Franz, Nisha Singh, and Stephen J. Lippard, Angew. Chem., Int. Ed., 39, 2120-2122 (2000).
A New Cell-Permeable Fluorescent Probe for Zn2+. Grant K. Walkup, Shawn C. Burdette, Stephen J. Lippard, and Roger Y. Tsien, J. Am. Chem. Soc., 122, 5644-5645 (2000).
Sequencing and analysis of the Methylococcus capsulatus (Bath) soluble methane monooxygenase genes. David E. Coufal, Jessica L. Blazyk, Douglas A. Whittington, Wayne W. Wu, Amy C. Rosenzweig, and Stephen J. Lippard, Eur. J. Biochem., 267, 2174-2185 (2000).
Steroid hormones induce HMG1 overexpression and sensitize breast cancer cells to cisplatin and carboplatin. Qing He, Cynthia H. Liang, and Stephen J. Lippard, Proc. Natl. Acad. Sci. U. S. A., 97, 5768-5772 (2000).
Valence-Delocalized Diiron(II,III) Cores Supported by Carboxylate-Only Bridging Ligands. Dongwhan Lee, Carsten Krebs, Boi Hanh Huynh, Michael P. Hendrich, and Stephen J. Lippard, J. Am. Chem. Soc., 122, 5000-5001 (2000).
Bio-inorganic chemistry: Newly charted waters: Editorial Overview. Stephen J. Lippard and Jeremy M. Berg, Curr. Opin. Chem. Biol., 4, 137-139 (2000).
DNA Sequence Context Modulates the Impact of a Cisplatin 1,2-d(GpG) Intrastrand Cross-link on the Conformational and Thermodynamic Properties of Duplex DNA. Daniel S. Pilch, Shari U. Dunham, Elizabeth R. Jamieson, Stephen J. Lippard, and Kenneth J. Breslauer, J. Mol. Biol., 296, 803-812 (2000).
Large Scale ab Initio Quantum Chemical Calculation of the Intermediates in the Soluble Methane Monooxygenase Catalytic Cycle. Barry D. Dunietz, Michael D. Beachy, Yixiang Cao, Douglas A. Whittington, Stephen J. Lippard, and Richard A. Friesner, J. Am. Chem. Soc., 122, 2828-2839 (2000).
Modeling Carboxylate-Bridged Dinuclear Active Sites in Metalloenzymes Using a Novel Naphthyridine-Based Dinucleating Ligand. Chuan He and Stephen J. Lippard, J. Am. Chem. Soc., 122, 184-185 (2000).
1999
Cationic Species Can Be Produced in Soluble Methane Monooxygenase-Catalyzed Hydroxylation Reactions; Radical Intermediates Are Not Formed. Seung-Yong Choi, Philip E. Eaton, Daniel A. Kopp, Stephen J. Lippard, Martin Newcomb, and Runnan Shen, J. Am. Chem. Soc., 121, 12198-12199 (1999).
Synthesis of Unsymmetrical Diolate, Oxametallacyclopentene, Amido-Alkoxide and Thiolato-Alkoxide Complexes Using Dialkyl and Diaryl Titanium Aminotroponiminate Complexes: A Route to Unsymmetrical Vicinal Diols. Dietrich P. Steinhuebel and Stephen J. Lippard, J. Am. Chem. Soc., 121, 11762-11772 (1999).
Amide Hydrolysis Effected by a Hydroxo-Bridged Dinickel(II) Complex: Insights into the Mechanism of Urease. Amy M. Barrios and Stephen J. Lippard, J. Am. Chem. Soc., 121, 11751-11757 (1999).
Synthetic and Structural Studies of Titanium Aminotroponiminate Complexes. Dietrich P. Steinhuebel and Stephen J. Lippard, Inorg. Chem., 38, 6225-6233 (1999).
NO Disproportionation Reactivity of Fe Tropocoronand Complexes. Katherine J. Franz and Stephen J. Lippard, J. Am. Chem. Soc., 121, 10504-10512 (1999).
Identification by NMR Spectroscopy of Residues at Contact Surfaces in Large, Slowly Exchanging Macromolecular Complexes. Hiroshi Matsuo, Kylie J. Walters, Kenta Teruya, Takeyuki Tanaka, George T. Gassner, Stephen J. Lippard, Yoshimasa Kyogoku, and Gerhard Wagner, J. Am. Chem. Soc., 121, 9903-9904 (1999).
Formation of Fe(III)Fe(IV) Species from the Reaction between a Diiron(II) Complex and Dioxygen: Relevance to Ribonucleotide Reductase Intermediate X. Dongwhan Lee, J. Du Bois, Doros Petasis, Michael P. Hendrich, Carsten Krebs, Boi Hanh Huynh, and Stephen J. Lippard, J. Am. Chem. Soc., 121, 9893-9894 (1999).
Component Interactions in the Soluble Methane Monooxygenase System from Methylococcus capsulatus (Bath). George T. Gassner and Stephen J. Lippard, Biochemistry, 38, 12768-12785 (1999).
Synthesis and Characterization of (Aminotroponiminato)titanium(IV) Dialkyl Complexes: Control of Reactivity by Ligand Design. Dietrich P. Steinheubel and Stephen J. Lippard, Organometallics, 18, 3959-3961 (1999).
Toxicity of platinum(II) amino acid (N,O) complexes parallels their binding to DNA as measured in a new solid phase assay involving a fluorescent HMG1 protein construct readout. Christopher J. Ziegler, Karen E. Sandman, Cynthia H. Liang, and Stephen J. Lippard, J. Biol. Inorg. Chem., 4, 402-411 (1999).
Structural and Spectroscopic Comparisons between (μ-Oxo)- and (μ-Hydroxo)bis(μ-carboxylato)diiron(III) Complexes That Contain All-Oxygen-Donor Ligands. Tadashi J. Mizoguchi, Roman M. Davydov, and Stephen J. Lippard, Inorg. Chem., 38, 4098-4103 (1999).
Structure, Recognition, and Processing of Cisplatin-DNA Adducts. Elizabeth R. Jamieson and Stephen J. Lippard, Chem. Rev., 99, 2467-2498 (1999).
Rapid fluorescence-based reporter-gene assays to evaluate the cytotoxicity and antitumor drug potential of platinum complexes. Karen E. Sandman, Sudhakar S. Marla, Gregor Zlokarnik, and Stephen J. Lippard, Chem. Biol., 6, 541-551 (1999).
Methylation of Iron–Sulfur Complexes by Trimethyl Phosphate. Jonathan J. Wilker and Stephen J. Lippard, Inorg. Chem., 38, 3569-3574 (1999).
Structure of the soluble methane monooxygenase regulatory protein B. Kylie J. Walters, George T. Gassner, Stephen J. Lippard, and Gerhard Wagner, Proc. Natl. Acad. Sci. U. S. A., 96, 7877-7882 (1999).
Anticancer Activity of Cisplatin and Related Complexes. Andrew Gelasco and Stephen J. Lippard, In: Metallopharmaceuticals I. Topics in Biological Inorganic Chemistry, Michael J. Clarke, Peter J. Sadler, Eds., Springer-Verlag: Heidelberg, 1, 1-43 (1999).
Mutational and structural analyses of the regulatory protein B of soluble methane monooxygenase from Methylococcus capsulatus (Bath). Hans Brandstetter, Douglas A. Whittington, Stephen J. Lippard, and Christin A. Frederick, Chem. Biol., 6, 441-449 (1999).
Dioxygen and alkane activation by iron-containing enzymes. Shannon S. Stahl and Stephen J. Lippard, In: Iron Metabolism: Inorganic Biochemistry and Regulatory Mechanisms, Glória C. Ferreira, José J. G. Moura, and Ricardo Franco, Eds., Wiley-VCH Verlag: Weinheim, Germany, 303-321 (1999).
Basis for recognition of cisplatin-modified DNA by high-mobility-group proteins. Uta-Maria Ohndorf, Mark A. Rould, Qing He, Carl O. Pabo, and Stephen J. Lippard, Nature, 399, 708-712 (1999).
The Reactivity of Well Defined Diiron(III) Peroxo Complexes Toward Substrates: Addition to Electrophiles and Hydrocarbon Oxidation. Daniel D. LeCloux, Amy M. Barrios, and Stephen J. Lippard, Bioorg. Med. Chem., 7, 763-772 (1999).
Structural and Kinetic Studies of a Cisplatin-modified DNA Icosamer Binding to HMG1 Domain B. Elizabeth R. Jamieson, Matthew P. Jacobson, Carmen M. Barnes, Christine S. Chow, and Stephen J. Lippard, J. Biol. Chem., 274, 12346-12354 (1999).
Mechanistic Studies of the Reaction of Reduced Methane Monooxygenase Hydroxylase with Dioxygen and Substrates. Ann M. Valentine, Shannon S. Stahl, and Stephen J. Lippard, J. Am. Chem. Soc., 121, 3876-3887 (1999).
Free Copper Ions in the Cell? Stephen J. Lippard, Science, 284, 748-749, (1999).
Methods for Screening the Potential Antitumor Activity of Platinum Compounds in Combinatorial Libraries. Karen E. Sandman and Stephen J. Lippard, In: Cisplatin: Chemistry and Biochemistry of a Leading Anticancer Drug, Bernhard Lippert, Ed., Wiley-VCH: Weinheim, Germany, 523-536 (1999).
The Response of Cellular Proteins to Cisplatin-Damaged DNA. Deborah B. Zamble and Stephen J. Lippard, In: Cisplatin: Chemistry and Biochemistry of a Leading Anticancer Drug, Bernhard Lippert, Ed., Wiley-VCH: Weinheim, Germany, 73-110 (1999).
Oxidation of Ultrafast Radical Clock Substrate Probes by the Soluble Methane Monooxygenase from Methylococcus capsulatus (Bath). Ann M. Valentine, Marie-Helene LeTadic-Biadatti, Patrick H. Toy, Martin Newcomb, and Stephen J. Lippard, J. Biol. Chem., 274, 10771-10776 (1999).
Reactions of Nitric Oxide with the Reduced Non-Heme Diiron Center of the Soluble Methane Monooxygenase Hydroxylase. David E. Coufal, Pedro Tavares, Alice S. Pereira, Boi Hanh Huynh, and Stephen J. Lippard, Biochemistry, 38, 4504-4513 (1999).
An EPR Study of the Dinuclear Iron Site in the Soluble Methane Monooxygenase from Methylococcus capsulatus (Bath) Reduced by One Electron at 77 K: The Effects of Component Interactions and the Binding of Small Molecules to the Diiron(III) Center. Roman Davydov, Ann M. Valentine, Sonja Komar-Panicucci, Brian M. Hoffman, and Stephen J. Lippard, Biochemistry, 38, 4188-4197 (1999).
Synthesis of Unsymmetrical Vicinal Diols Using Titanium Aminotroponiminate Alkyl Complexes. Dietrich P. Steinhuebel and Stephen J. Lippard, Organometallics, 18, 109-111 (1999).
Single d(GpG)/cis-Diammineplatinum(II) Adduct-Induced Inhibition of DNA Polymerization. Zucai Suo, Stephen J. Lippard, and Kenneth A. Johnson, Biochemistry, 38, 715-726 (1999).
1998
Mixed-Valence CuI–CuII and Heterodimetallic CuI–MII Bis(carboxylate-bridged) Complexes: Structural, Electrochemical, and Spectroscopic Investigations. Daniel D. LeCloux, Roman Davydov, and Stephen J. Lippard, Inorg. Chem., 37, 6814-6826 (1998).
Structural and Functional Models of the Dioxygen-Activating Centers of Non-Heme Diiron Enzymes Ribonucleotide Reductase and Soluble Methane Monooxygenase. Dongwhan Lee and Stephen J. Lippard, J. Am. Chem. Soc., 120, 12153-12154 (1998).
Synthetic Models of the Deoxy and Oxy Forms of the Non-Heme Dioxygen-Binding Protein Hemerythrin. Tadashi J. Mizoguchi and Stephen J. Lippard, J. Am. Chem. Soc., 120, 11022-11023 (1998).
Synthesis and Triiron Complexes of PDK, a New Porphyrin-Linked Dicarboxylate Ligand. Xiao-Xiang Zhang, Peter Fuhrmann, and Stephen J. Lippard, J. Am. Chem. Soc., 120, 10260-10261 (1998).
A Novel Nonairon(III) Citrate Complex: A "Ferric Triple-Decker." Avi Bino, Itzhak Shweky, Shmuel Cohen, Erika R. Bauminger, and Stephen J. Lippard, Inorg. Chem., 37, 5168-5172 (1998).
Small Molecule Binding to the Mixed-Valent Diiron Center of Methane Monooxygenase Hydroxylase from Methylococcus capsulatus (Bath) as Revealed by ENDOR Spectroscopy. Jean-Paul Willems, Ann M. Valentine, Ryszard Gurbiel, Stephen J. Lippard, and Brian M. Hoffman, J. Am. Chem. Soc., 120, 9410-9416 (1998).
Disproportionation of Nitric Oxide Promoted by a Mn Tropocoronand. Katherine J. Franz and Stephen J. Lippard, J. Am. Chem. Soc., 120, 9034-9040 (1998).
Modeling the Diiron Centers of Non-Heme Iron Enzymes. Preparation of Sterically Hindered Diiron(II) Tetracarboxylate Complexes and Their Reactions with Dioxygen. Daniel D. LeCloux, Amy M. Barrios, Tadashi J. Mizoguchi, and Stephen J. Lippard, J. Am. Chem. Soc., 120, 9001-9014 (1998).
Synthesis and Characterization of Spin-Delocalized Carboxylate-Bridged Cu(I)–Cu(II) Mixed-Valence Complexes Having Only Oxygen Donor Ligands. Daniel D. LeCloux, Roman Davydov, and Stephen J. Lippard, J. Am. Chem. Soc., 120, 6810-6811 (1998).
Amino Acid Side Chain Movements in the Active Site of the Hydroxylase Enzyme from Soluble Methane Monooxygenase. Douglas A. Whittington and Stephen J. Lippard, In: Spectroscopic Methods in Bioinorganic Chemistry, Edward I. Solomon and Keith O. Hodgson, Eds., ACS Symp. Ser., 692, 334-347 (1998).
NMR Solution Structure of a DNA Dodecamer Duplex Containing a cis-Diammineplatinum(II) d(GpG) Intrastrand Cross-Link, the Major Adduct of the Anticancer Drug Cisplatin. Andrew Gelasco and Stephen J. Lippard, Biochemistry, 37, 9230-9239 (1998).
Substrate binding and C-H bond activation in the soluble methane monooxygenase hydroxylase. Douglas A. Whittington, Ann M. Valentine, and Stephen J. Lippard, J. Biol. Inorg. Chem., 3, 307-313 (1998).
Solution Structure of a DNA Duplex Containing a Nitroxide Spin-Labeled Platinum d(GpG) Intrastrand Cross-Link Refined with NMR-Derived Long-Range Electron-Proton Distance Restraints. Shari U. Dunham, Stephen U. Dunham, Christopher J. Turner, and Stephen J. Lippard, J. Am. Chem. Soc., 120, 5395-5406 (1998).
p53-dependent and -independent responses to cisplatin in mouse testicular teratocarcinoma cells. Deborah B. Zamble, Tyler Jacks, and Stephen J. Lippard, Proc. Natl. Acad. Sci. U. S. A., 95, 6163-6168 (1998).
Synthesis and Reactivity of Cationic Group 4 Tropocoronand Complexes. Michael J. Scott and Stephen J. Lippard, Organometallics, 17, 1769-1773 (1998).
Telomere loss in cells treated with cisplatin. Toru Ishibashi and Stephen J. Lippard, Proc. Natl. Acad. Sci. U. S. A., 95, 4219-4223 (1998).
A mechanism-based, solution-phase method for screening combinatorial mixtures of potential platinum anticancer drugs. Karen E. Sandman, Peter Fuhrmann, and Stephen J. Lippard, J. Biol. Inorg. Chem., 3, 74-80 (1998).
Synthesis, characterization, and reactivity of organometallic Zr(IV) carboxylate complexes. Dietrich P. Steinhuebel, Peter Fuhrmann, and Stephen J. Lippard, Inorg. Chim. Acta, 270, 527-536 (1998).
Generation of a Mixed-Valent Fe(III)Fe(IV) Form of Intermediate Q in the Reaction Cycle of Soluble Methane Monooxygenase, an Analog of Intermediate X in Ribonucleotide Reductase R2 Assembly. Ann M. Valentine, Pedro Tavares, Alice S. Pereira, Roman Davydov, Carsten Krebs, Brian M. Hoffman, Dale E. Edmondson, Boi Hanh Huynh, and Stephen J. Lippard, J. Am. Chem. Soc., 120, 2190-2191 (1998).
Reactivity of the Coordinated η2-Ketone in the Tropocoronand Complex [Hf(TC-3,5)(η2-OC(CH2Ph)2)]: N–C Coupling, C–C Coupling, and Insertion into the C–O Bond. Michael J. Scott and Stephen J. Lippard, Organometallics, 17, 466-474 (1998).
Aminoguanidinium Hydrolysis Effected by a Hydroxo-Bridged Dicobalt(II) Complex as a Functional Model for Arginase and Catalyzed by Mononuclear Cobalt(II) Complexes. Chuan He and Stephen J. Lippard, J. Am. Chem. Soc., 120, 105-113 (1998).
Human Testis-Determining Factor SRY Binds to the Major DNA Adduct of Cisplatin and a Putative Target Sequence with Comparable Affinities. Elizabeth E. Trimmer, Deborah B. Zamble, Stephen J. Lippard, and John M. Essigmann, Biochemistry, 37, 352-362 (1998).
1997
Structure and Biochemistry of Methane Monooxygenase Enzyme Systems. Amy C. Rosenzweig and Stephen J. Lippard, In: Transition Metals in Microbial Metabolism, Günther Winkelmann, Carl J. Carrano, Eds., Harwood Academic Publishers: Amsterdam, 257-279 (1997).
Isocyanide Insertion Reactions with Organometallic Group 4 Tropocoronand Complexes: Formation of η2-Iminoacyl, Enediamido, η2-Imine, and μ-Imido Products. Michael J. Scott and Stephen J. Lippard, Organometallics, 16, 5857-5868 (1997).
A Cyclic Octadecairon(III) Complex, the Molecular 18-Wheeler. Stephen P. Watton, Peter Fuhrmann, Laura E. Pence, Andrea Caneschi, Andrea Cornia, Gian Luca Abbati, and Stephen J. Lippard, Angew. Chem., Int. Ed., 36, 2774-2776 (1997).
Binding of tsHMG, a Mouse Testis-Specific HMG-Domain Protein, to Cisplatin-DNA Adducts. Uta-Maria Ohndorf, Joyce P. Whitehead, Nalini L. Raju, and Stephen J. Lippard, Biochemistry, 36, 14807-14815 (1997).
Principles of small molecule activation by metalloenzymes as exemplified by the soluble methane monooxygenase from Methylococcus capsulatus (Bath). Ann M. Valentine and Stephen J. Lippard, J. Chem. Soc., Dalton Trans., 3925-3931 (1997).
Synthesis and characterization of Zr(IV) and Hf(IV) tropocoronand complexes. Michael J. Scott and Stephen J. Lippard, Inorg. Chim. Acta, 263, 287-299 (1997).
Crystal Structures of the Methane Monooxygenase Hydroxylase From Methylococcus capsulatus (Bath): Implications for Substrate Gating and Component Interactions. Amy C. Rosenzweig, Hans Brandstetter, Douglas A. Whittington, Pär Nordlund, Stephen J. Lippard, and Christin A. Frederick, Proteins, 29, 141-152 (1997).
(μ-Oxo)bis(μ-carboxylato)bis(2,2’-bipyridyl)bis(X)diiron(III) Complexes, X = NCS-, NCSe-, and N3-: Synthetic Models of Pseudohalide Derivatives of Carboxylate-Bridged Diiron Proteins. Tadashi J. Mizoguchi and Stephen J. Lippard, Inorg. Chem., 36, 4526-4533 (1997).
DNA Sequence Context and Protein Composition Modulate HMG-Domain Protein Recognition of Cisplatin-Modified DNA. Shari U. Dunham and Stephen J. Lippard, Biochemistry, 36, 11428-11436 (1997).
Synthesis and Characterization of a Novel Class of Dicopper(I) Bis(carboxylate)-Bridged Complexes. Daniel D. LeCloux and Stephen J. Lippard, Inorg. Chem., 36, 4035-4046 (1997).
Tuning of Electronic Properties and Reactivity in Four-Coordinate Cobalt(III) Complexes by the Tetraazamacrocyclic Tropocoronand Ligand. Linda H. Doerrer, Maria T. Bautista, and Stephen J. Lippard, Inorg. Chem., 36, 3578-3579 (1997).
Differences in the Reactivity of [Ag(PBu3)I]4 and [Cu(PBu3)I]4 in Promoting Conjugate Addition. R. Bryan Klassen and Stephen J. Lippard, Organometallics, 16, 3623-3627 (1997).
Zinc and Cadmium Tropocoronand Complexes: Effect of Metal Ion Radius on Macrocyclic Ligand Twist and Fold. Linda H. Doerrer and Stephen J. Lippard, Inorg. Chem., 36, 2554-2563 (1997).
Methyl Transfer to Mercury Thiolates: Effects of Coordination Number and Ligand Dissociation. Jonathan J. Wilker, Karen E. Wetterhahn, and Stephen J. Lippard, Inorg. Chem., 36, 2079-2083 (1997).
Coupling of Carbon Monoxide to Isocyanides and Enones Induced by Alkyl Zr(IV) and Hf(IV) Tropocoronand Complexes. Michael J. Scott and Stephen J. Lippard, J. Am. Chem. Soc., 119, 3411-3412 (1997).
Alkyl Transfer to Metal Thiolates: Kinetics, Active Species Identification, and Relevance to the DNA Methyl Phosphotriester Repair Center of Escherichia coli Ada. Jonathan J. Wilker and Stephen J. Lippard, Inorg. Chem., 36, 969-978 (1997).
Tritiated Chiral Alkanes as Substrates for Soluble Methane Monooxygenase from Methylococcus capsulatus (Bath): Probes for the Mechanism of Hydroxylation. Ann M. Valentine, Barrie Wilkinson, Katherine E. Liu, Sonja Komar-Panicucci, Nigel D. Priestley, Philip G. Williams, Hiromi Morimoto, Heinz G. Floss, and Stephen J. Lippard, J. Am. Chem. Soc., 119, 1818-1827 (1997).
A Hexairon(III) Complex with Three Nonplanar η2-μ4-Peroxo Ligands Bridging Two Basic Iron Acetate Units. Itzhak Shweky, Laura E. Pence, Georgia C. Papaefthymiou, Roberta Sessoli, Joanne W. Yun, Avi Bino, and Stephen J. Lippard, J. Am. Chem. Soc., 119, 1037-1042 (1997).
Non-Kramers ESEEM of Integer-Spin Diferrous Carboxylate-Bridged Clusters in Proteins. Bradley E. Sturgeon, Peter E. Doan, Katherine E. Liu, Doug Burdi, Wing H. Tong, Judith M. Nocek, Nishi Gupta, JoAnne Stubbe, Donald M. Kurtz, Jr., Stephen J. Lippard, and Brian M. Hoffman, J. Am. Chem. Soc., 119, 375-386 (1997).
Kinetic Studies of Reactions of Dioxygen with Carboxylate-Bridged Diiron(II) Complexes Leading to the Formation of (μ-Oxo)diiron(III) Complexes. Andrew L. Feig, Axel Masschelein, Andreja Bakac, and Stephen J. Lippard, J. Am. Chem. Soc., 119, 334-342 (1997).
Synthesis, Characterization, and Magnetic Studies of Two Novel Isostructural Pentanuclear Iron(II) Complexes. Susanna Herold and Stephen J. Lippard, Inorg. Chem., 36, 50-58 (1997).
Carboxylate-Bridged Diiron(II) Complexes: Synthesis, Characterization and O2-Reactivity of Models for the Reduced Diiron Centers in Methane Monooxygenase and Ribonucleotide Reductase. Susanna Herold and Stephen J. Lippard, J. Am. Chem. Soc., 119, 145-156 (1997).
Cisplatin and Related Drugs. Pieter Pil and Stephen J. Lippard, In: Encyclopedia of Cancer, Joseph R. Bertino, Ed., Academic Press: San Diego, CA, 1, 392-410 (1997).
1996
Carboxylate- and Phosphate Ester-Bridged Dimagnesium(II), Dizinc(II) and Dicalcium(II) Complexes. Models for Intermediates in Biological Phosphate Ester Hydrolysis. Joanne W. Yun, Tomoaki Tanase, and Stephen J. Lippard, Inorg. Chem., 35, 7590-7600 (1996).
Crystal Structure of the Anticancer Drug Cisplatin Bound to Duplex DNA. Patricia M. Takahara, Christin A. Frederick, and Stephen J. Lippard, J. Am. Chem. Soc., 118, 12309-12321 (1996).
A Carboxylate-Bridged Non-Heme Diiron Dinitrosyl Complex. Andrew L. Feig, Maria T. Bautista, and Stephen J. Lippard, Inorg. Chem., 35, 6892-6898 (1996).
Cisplatin-DNA Structure and Function. Stephen J. Lippard, Helix, 5, 34-35 (1996).
Repair of Cisplatin-DNA Adducts by the Mammalian Excision Nuclease. Deborah B. Zamble, David Mu, Joyce T. Reardon, Aziz Sancar, and Stephen J. Lippard, Biochemistry, 35, 10004-10013 (1996).
Influence of cisplatin intrastrand crosslinking on the conformation, thermal stability, and energetics of a 20-mer DNA duplex. Nataša Poklar, Daniel S. Pilch, Stephen J. Lippard, Elizabeth A. Redding, Shari U. Dunham, and Kenneth J. Breslauer, Proc. Natl. Acad. Sci. U. S. A., 93, 7606-7611 (1996).
Regiochemical Variations in Reactions of Methylcubane with tert-Butoxyl Radical, Cytochrome P-450 Enzymes, and a Methane Monooxygenase System. Seung-Yong Choi, Philip E. Eaton, Paul F. Hollenberg, Katherine E. Liu, Stephen J. Lippard, Martin Newcomb, David A. Putt, Subhash P. Upadhyaya, and Yusheng Xiong, J. Am. Chem. Soc., 118, 6547-6555 (1996).
Carboxylate Shifts in the Active Site of the Hydroxylase Component of Soluble Methane Monooxygenase from Methylococcus capsulatus (Bath). Amy C. Rosenzweig, Christin A. Frederick, and Stephen J. Lippard, In: Microbial Growth on C1 Compounds: Proceedings of the 8th International Symposium, Mary E. Lidstrom and F. Robert Tabita, Eds., Kluwer Academic Publishers: Dordrecht, The Netherlands, 141-149 (1996).
Zinc-Containing Carboxylate-Bridged Heterodimetallic Complexes and Their Reactions with Phosphodiester Ligands. Tomoaki Tanase, Joanne W. Yun, and Stephen J. Lippard, Inorg. Chem., 35, 3585-3594 (1996).
Magnetic properties of dodecanuclear mixed valence iron clusters. Andrea Caneschi, Andrea Cornia, Stephen J. Lippard, Georgia C. Papaefthymiou, and Roberta Sessoli, Inorg. Chim. Acta, 243, 295-304 (1996).
Automated Solid-Phase Synthesis of Site-Specifically Platinated Oligodeoxyribonucleotides. Rajesh Manchanda, Stephen U. Dunham, and Stephen J. Lippard, J. Am. Chem. Soc., 118, 5144-5145 (1996).
Structure and Mössbauer Spectrum of a (μ-1,2-Peroxo)bis(μ-carboxylato)diiron(III) Model for the Peroxo Intermediate in the Methane Monooxygenase Hydroxylase Reaction Cycle. Kimoon Kim and Stephen J. Lippard, J. Am. Chem. Soc., 118, 4914-4915 (1996).
Binding of Ixr1, a Yeast HMG-Domain Protein, to Cisplatin-DNA Adducts in Vitro and in Vivo. Megan M. McA'Nulty, Joyce P. Whitehead, and Stephen J. Lippard, Biochemistry, 35, 6089-6099 (1996).
Synthesis, Structural Studies, and Magnetic Exchange Interactions in Low-Valent Manganese Alkoxide Cubes. Laura E. Pence, Andrea Caneschi, and Stephen J. Lippard, Inorg. Chem., 35, 3069-3072 (1996).
Mechanistic Studies of the Formation and Decay of Diiron(III) Peroxo Complexes in the Reaction of Diiron(II) Precursors with Dioxygen. Andrew L. Feig, Michael Becker, Siegfried Schindler, Rudi van Eldik, and Stephen J. Lippard, Inorg. Chem., 35, 2590-2601 (1996).
Proteins That Bind to and Mediate the Biological Activity of Platinum Anticancer Drug-DNA Adducts. Joyce P. Whitehead and Stephen J. Lippard, In: Metal Ions in Biological Systems: Interactions of Metal Ions with Nucleotides, Nucleic Acids, and Their Constituents, Astrid Sigel and Helmut Sigel, Eds., Marcel Dekker: New York, 32, 687-726 (1996).
Photoreactivity of Platinum(II) in Cisplatin-Modified DNA Affords Specific Cross-Links to HMG Domain Proteins. Stefanie A. Kane and Stephen J. Lippard, Biochemistry, 35, 2180-2188 (1996).
The HMG-domain protein Ixr1 blocks excision repair of cisplatin-DNA adducts in yeast. Megan M. McA'Nulty and Stephen J. Lippard, Mutat. Res., DNA Repair, 362, 75-86 (1996).
Investigation of the Dinuclear Fe Center of Methane Monooxygenase by Advanced Paramagnetic Resonance Techniques: On the Geometry of DMSO Binding. Victoria J. DeRose, Katherine E. Liu, Stephen J. Lippard, and Brian M. Hoffman, J. Am. Chem. Soc., 118, 121-134 (1996).
1995
Mutagenic and genotoxic effects of DNA adducts formed by the anticancer drug cisdiamminedichloroplatinum(II). Kevin J. Yarema, Stephen J. Lippard, and John M. Essigmann, Nucleic Acids Res., 23, 4066-4072 (1995).
DNA Adducts of cis-Diamminedichloroplatinum(II) and Its Trans Isomer Inhibit RNA Polymerase II Differentially in Vivo. Jill A. Mello, Stephen J. Lippard, and John M. Essigmann, Biochemistry, 34, 14783-14791 (1995).
Synthesis, Tuning of the Stereochemistry, and Physical Properties of Cobalt(II) Tropocoronand Complexes. B. Scott Jaynes, Linda H. Doerrer, Shuncheng Liu, and Stephen J. Lippard, Inorg. Chem., 34, 5735-5744 (1995).
Long-Range Distance Constraints in Platinated Nucleotides: Structure Determination of the 5' Orientational Isomer of cis-[Pt(NH3)(4-aminoTEMPO){d(GpG)}]+ from Combined Paramagnetic and Diamagnetic NMR Constraints with Molecular Modeling. Stephen U. Dunham and Stephen J. Lippard, J. Am. Chem. Soc., 117, 10702-10712 (1995).
Kinetic and Spectroscopic Characterization of Intermediates and Component Interactions in Reactions of Methane Monooxygenase from Methylococcus capsulatus (Bath). Katherine E. Liu, Ann M. Valentine, Danli Wang, Boi Hanh Huynh, Dale E. Edmondson, Athanasios Salifoglou, and Stephen J. Lippard, J. Am. Chem. Soc., 117, 10174-10185 (1995).
Cisplatin and DNA repair in cancer chemotherapy. Deborah B. Zamble and Stephen J. Lippard, Trends Biochem. Sci., 20, 435-439 (1995).
Crystal structure of double-stranded DNA containing the major adduct of the anticancer drug cisplatin. Patricia M. Takahara, Amy C. Rosenzweig, Christin A. Frederick, and Stephen J. Lippard, Nature, 377, 649-652 (1995).
Surface and Electrostatic Contributions to DNA-Promoted Reactions of Platinum(II) Complexes with Short Oligonucleotides: A Kinetic Study. Sofi K. C. Elmroth and Stephen J. Lippard, Inorg. Chem., 34, 5234-5243 (1995).
Dimolybdenum(II) Calixarene Complexes: Synthesis, Structure, Raman Spectroscopy, and Bonding. Jacqueline A. Acho, Tong Ren, Joanne W. Yun, and Stephen J. Lippard, Inorg. Chem., 34, 5226-5233 (1995).
Modeling Phenoxyl Radical Metalloenzyme Active Sites. David P. Goldberg and Stephen J. Lippard, Adv. Chem. Ser., 246, 61-81 (1995).
Studies of the Soluble Methane Monooxygenase Protein System: Structure, Component Interactions, and Hydroxylation Mechanism. Katherine E. Liu and Stephen J. Lippard, Adv. Inorg. Chem., 42, 263-289 (1995).
Dinuclear Manganese(II) Complexes with the {Mn2(μ-carboxylato)2}2+ Core and Their Transformation to (μ-Oxo)bis(μ-carboxylato)dimanganese(III) Complexes. Tomoaki Tanase and Stephen J. Lippard, Inorg. Chem., 34, 4682-4690 (1995).
Modeling the DNA Methylphosphotriester Repair Site in Escherichia coli Ada. Why Zinc and Four Cysteines? Jonathan J. Wilker and Stephen J. Lippard, J. Am. Chem. Soc., 117, 8682-8683 (1995).
Alkali metal-responsive geometric and spectral changes in a cobalt(II) complex of a constrained dicarboxylate: a carboxylate shift-mediated metallochromoionophore. Stephen P. Watton, Mindy I. Davis, Laura E. Pence, Julius Rebek, Jr., and Stephen J. Lippard, Inorg. Chim. Acta, 235, 195-204 (1995).
Mono- and Dinuclear Zinc Complexes of XDK, H2XDK = m-Xylenediamine Bis(Kemp's triacid imide), and Their Reaction with Phosphate Esters. Tomoaki Tanase, Joanne W. Yun, and Stephen J. Lippard, Inorg. Chem., 34, 4220-4229 (1995).
Geometry of the soluble methane monooxygenase catalytic diiron center in two oxidation states. Amy C. Rosenzweig, Pär Nordlund, Patricia M. Takahara, Christin A. Frederick, and Stephen J. Lippard, Chem. Biol., 2, 409-418 (1995).
Consequences of HMG-Domain Protein Binding to Cisplatin-Modified DNA. Megan M. McA'Nulty, and Stephen J. Lippard, Nucleic Acids Mol. Biol., 9, 264-284 (1995).
Carboxylate-Bridged Diiron(II) Complexes, Including a New Model for Reduced Methane Monooxygenase Hydroxylase and the R2 Protein of Ribonucleotide Reductase. Susanna Herold, Laura E. Pence, and Stephen J. Lippard, J. Am. Chem. Soc., 117, 6134-6135 (1995).
A Decanuclear Manganese Cluster with Oxo and Halide Bridging Ligands: Magnetic Behavior of an S ≥ 12 System. David P. Goldberg, Andrea Caneschi, Christopher D. Delfs, Roberta Sessoli, and Stephen J. Lippard, J. Am. Chem. Soc., 117, 5789-5800 (1995).
Ferromagnetic versus Antiferromagnetic Exchange in Five Structurally Analogous Carboxylate-Bridged Trinuclear Ferrous Complexes. David P. Goldberg, Joshua Telser, Cecilia M. Bastos, and Stephen J. Lippard, Inorg. Chem., 34, 3011-3024 (1995).
At Last–the Crystal Structure of Urease. Stephen J. Lippard, Science, 268, 996-997, (1995).
Reactions of Low-Valent Group V Dicarbonyl Phosphine Complexes with Carbon-Based Electrophiles to Produce Metal Alkyl, Acyl, Carbyne, and Acetylene Complexes. Brian S. Bronk, John D. Protasiewicz, Laura E. Pence, and Stephen J. Lippard, Organometallics, 14, 2177-2187 (1995).
Pentamethylcyclopentadienyl and Cyclopentadienyl Tantalum and Niobium Calixarene Compounds and Their Water and Acetonitrile Inclusion Complexes. Jacqueline A. Acho, Linda H. Doerrer, and Stephen J. Lippard, Inorg. Chem., 34, 2542-2556 (1995).
X-ray Absorption Spectroscopy Studies of the Diiron Center in Methane Monooxygenase in the Presence of Substrate and the Coupling Protein of the Enzyme System. Jane G. DeWitt, Amy C. Rosenzweig, Athanasios Salifoglou, Britt Hedman, Stephen J. Lippard, and Keith O. Hodgson, Inorg. Chem., 34, 2505-2515 (1995).
Characterization of a Diiron(III) Peroxo Intermediate in the Reaction Cycle of Methane Monooxygenase Hydroxylase from Methylococcus capsulatus (Bath). Katherine E. Liu, Ann M. Valentine, Di Qiu, Dale E. Edmondson, Evan H. Appelman, Thomas G. Spiro, and Stephen J. Lippard, J. Am. Chem. Soc., 117, 4997-4998 (1995).
Carboxylate- and Phosphodiester-Bridged Dinuclear Magnesium(II) Complexes. Joanne W. Yun, Tomoaki Tanase, Laura E. Pence, and Stephen J. Lippard, J. Am. Chem. Soc., 117, 4407-4408 (1995).
A (μ-Oxo)bis(μ-carboxylato)diiron(III) Complex with a Tethered Phenoxyl Radical as a Model for the Active Site of the R2 Protein of Ribonucleotide Reductase. David P. Goldberg, Dionysios Koulougliotis, Gary W. Brudvig, and Stephen J. Lippard, J. Am. Chem. Soc., 117, 3134-3144 (1995).
A Single HMG Domain in High-Mobility Group 1 Protein Binds to DNAs as Small as 20 Base Pairs Containing the Major Cisplatin Adduct. Christine S. Chow, Carmen M. Barnes, and Stephen J. Lippard, Biochemistry, 34, 2956-2964 (1995).
Reductive Coupling of Group 5 Dicarbonyls to Disiloxyacetylene Complexes: Ring Formation and Effects of Increasing Steric Demands. Brian S. Bronk, John D. Protasiewicz, and Stephen J. Lippard, Organometallics, 14, 1385-1392 (1995).
A Cyclic Hexairon(III) Complex with an Octahedrally Coordinated Sodium Ion at the Center, an Example of the [12]Metallacrown-6 Structure Type. Andrea Caneschi, Andrea Cornia, and Stephen J. Lippard, Angew. Chem., Int. Ed., 34, 467-469 (1995).
Calixarene complexes of the molybdenum-molybdenum quadruple bond. Jacqueline A. Acho and Stephen J. Lippard, Inorg. Chim. Acta, 229, 5-8 (1995).
Platinum Anticancer Drugs. Stephen J. Lippard, In: Bioinorganic Chemistry: An Inorganic Perspective of Life. NATO ASI Series, Dimitris P. Kessissoglou, Ed., Kluwer Academic Publishers: Dordrecht, The Netherlands, 459, 131-140 (1995).
Methane Monooxygenase. Stephen J. Lippard, In: Bioinorganic Chemistry: An Inorganic Perspective of Life. NATO ASI Series, Dimitris P. Kessissoglou, Ed., Kluwer Academic Publishers: Dordrecht, The Netherlands, 459, 1-12 (1995).
1994
HMG Domain Proteins Induce Sharp Bends in Cisplatin-Modified DNA. Christine S. Chow, Joyce P. Whitehead, and Stephen J. Lippard, Biochemistry, 33,15124-15130 (1994).
Syntheses, Structures, and Magnetic Properties of Two Dinuclear Iron(III) Citrate Complexes. Itzhak Shweky, Avi Bino, David P. Goldberg, and Stephen J. Lippard, Inorg. Chem., 33, 5161-5162 (1994).
HMG-domain proteins specifically inhibit the repair of the major DNA adduct of the anticancer drug cisplatin by human excision nuclease. Juch-Chin Huang, Deborah B. Zamble, Joyce T. Reardon, Stephen J. Lippard, and Aziz Sancar, Proc. Natl. Acad. Sci. U. S. A., 91, 10394-10398 (1994).
Platinum-Based Anticancer Drugs. Steven J. Brown, Christine S. Chow, and Stephen J. Lippard, In: Encyclopedia of Inorganic Chemistry, R. Bruce King, Ed., John Wiley & Sons Ltd.: Chichester, England, 6, 3305-3315 (1994).
Carboxylate-Bridged Heterodimetallic Complexes. Tomoaki Tanase, Stephen P. Watton, and Stephen J. Lippard, J. Am. Chem. Soc., 116, 9401-9402 (1994).
Mechanistic Studies of the Reaction of Dioxygen with Dinuclear Iron(II) Compounds to Form (μ-Peroxo)diiron(III) Complexes. Andrew L. Feig and Stephen J. Lippard, J. Am. Chem. Soc., 116, 8410-8411 (1994).
Polyiron Oxo Chemistry at the Molecular/Solid-State Boundary: Synthesis, Structure, and Magnetic and Mössbauer Properties of [Fe16MO10(OH)10(O2CPh)20] Complexes, M = Mn, Fe, or Co. Wolfgang Micklitz, Vickie McKee, R. Lynn Rardin, Laura E. Pence, Georgia C. Papaefthymiou, Simon G. Bott, and Stephen J. Lippard, J. Am. Chem. Soc., 116, 8061-8069 (1994).
Determining the Structure of a Hydroxylase Enzyme That Catalyzes the Conversion of Methane to Methanol in Methanotrophic Bacteria. Amy C. Rosenzweig and Stephen J. Lippard, Acc. Chem. Res., 27, 229-236 (1994).
Spectroscopic Detection of Intermediates in the Reaction of Dioxygen with the Reduced Methane Monooxygenase Hydroxylase from Methylococcus capsulatus (Bath). Katherine E. Liu, Danli Wang, Boi Hanh Huynh, Dale E. Edmondson, Athanasios Salifoglou, and Stephen J. Lippard, J. Am. Chem. Soc., 116, 7465-7466 (1994).
ESEEM and ENDOR Magnetic Resonance Studies of the Non-Kramers Doublet in the Integer-Spin Diiron(II) Forms of Two Methane Monooxygenase Hydroxylases and Hemerythrin Azide. Brian M. Hoffman, Bradley E. Sturgeon, Peter E. Doan, Victoria J. DeRose, Katherine E. Liu, and Stephen J. Lippard, J. Am. Chem. Soc., 116, 6023-6024 (1994).
Metals in Medicine. Stephen J. Lippard, In: Bioinorganic Chemistry, Ivano Bertini, Harry B. Gray, Stephen J. Lippard, Joan S. Valentine, Eds., University Science Books: Mill Valley, CA, 505-583 (1994).
Nuclear Hyperfine Coupling of Nitrogen in the Coordination Sphere of the Diiron Center of Methane Monooxygenase Hydroxylase. Christopher J. Bender, Amy C. Rosenzweig, Stephen J. Lippard, and Jack Peisach, J. Biol. Chem., 269, 15993-15998 (1994).
Synthesis, Structure, and Reactivity of (μ-Oxo)bis(μ-carboxylato)diiron(III) Complexes of a Dinucleating Dicarboxylate Ligand, Stable Models for Non-heme Diiron Protein Cores. Stephen P. Watton, Axel Masschelein, Julius Rebek, Jr., and Stephen J. Lippard, J. Am. Chem. Soc., 116, 5196-5205 (1994).
Structural and Biological Consequences of Platinum Anticancer Drug Binding to DNA. Stephen J. Lippard, In: Proceedings of the Robert A. Welch Foundation 37th Conference on Chemical Research, 40 Years of the DNA Double Helix, October 1993, 49-60 (1994).
Reactions of Non-Heme Iron(II) Centers with Dioxygen in Biology and Chemistry. Andrew L. Feig and Stephen J. Lippard, Chem. Rev., 94, 759-805 (1994).
Platinum Binding to d(GpG) Target Sequences and Phosphorothioate Linkages in DNA Occurs More Rapidly with Increasing Oligonucleotide Length. Sofi K. C. Elmroth and Stephen J. Lippard, J. Am. Chem. Soc., 116, 3633-3634 (1994).
Electrophile-Promoted Carbyne-CO Coupling at a Tantalum Center. John D. Protasiewicz, Brian S. Bronk, Axel Masschelein, and Stephen J. Lippard, Organometallics, 13, 1300-1311 (1994).
Synthesis and Structural Characterization of [Cr(t-C4H9HNC≡CNH-t-C4H9)(CN-t-C4H9)4I]I. Reductive Coupling of Isocyanide Ligands in a First Row Transition Metal Complex. Jacqueline A. Acho and Stephen J. Lippard, Organometallics, 13, 1294-1299 (1994).
Synthesis, Structure, and Electronic Properties of a Mixed-Valent Dodecairon Oxo Complex, a Model for the Biomineralization of Ferritin. Kingsley L. Taft, Georgia C. Papaefthymiou, and Stephen J. Lippard, Inorg. Chem., 33, 1510-1520 (1994).
Effects of DNA Adduct Structure and Distribution on the Mutagenicity and Genotoxicity of Two Platinum Anticancer Drugs. Kevin J. Yarema, Jennifer M. Wilson, Stephen J. Lippard, and John M. Essigmann, J. Mol. Biol., 236, 1034-1048 (1994).
Synthesis and Characterization of Hydroxo-Bridged Diiron(III) Complexes Containing Carboxylate or Phosphate Ester Bridges: Comparisons to Diiron(III) Proteins. Petra N. Turowski, William H. Armstrong, Shuncheng Liu, Seth N. Brown, and Stephen J. Lippard, Inorg. Chem., 33, 636-645 (1994).
[Fe(OMe)2(O2CCH2Cl)]10, a Molecular Ferric Wheel. Kingsley L. Taft, Christopher D. Delfs, Georgia C. Papaefthymiou, Simon Foner, Dante Gatteschi, and Stephen J. Lippard, J. Am. Chem. Soc., 116, 823-832 (1994).
1993
Iron and Manganese Alkoxide Cubes. Kingsley L. Taft, Andrea Caneschi, Laura E. Pence, Christopher D. Delfs, Georgia C. Papaefthymiou, and Stephen J. Lippard, J. Am. Chem. Soc., 115, 11753-11766 (1993).
Synthesis, Characterization, DNA Binding Properties, and Solution Thermochromism of Platinum(II) Complexes of the Ethidium Cation: Regiospecifity in a DNA-Promoted Reaction. Tong Ren, Daniel P. Bancroft, Wesley I. Sundquist, Axel Masschelein, Michael V. Keck, and Stephen J. Lippard, J. Am. Chem. Soc., 115, 11341-11352 (1993).
Crystal structure of a bacterial non-haem iron hydroxylase that catalyses the biological oxidation of methane. Amy C. Rosenzweig, Christin A. Frederick, Stephen J. Lippard, and Pär Nordlund, Nature, 366, 537-543 (1993).
Methane Monooxygenase: Models and Mechanisms. Katherine E. Liu, Andrew L. Feig, David P. Goldberg, Stephen P. Watton, and Stephen J. Lippard, In: The Activation of Dioxygen and Homogeneous Catalytic Oxidation, Derek H.R. Barton, Arthur E. Martell, and Donald T. Sawyer, Eds., Plenum Press: New York, 301-320 (1993).
[Ni2(OAc)3(urea)(tmen)2](OTf) and [Ni(OAc)(urea)2(tmen)](OTf), Model Complexes for the Enzyme Urease. Heather E. Wages, Kingsley L. Taft, and Stephen J. Lippard, Inorg. Chem., 32, 4985-4987 (1993).
High-mobility-group 1 protein mediates DNA bending as determined by ring closures. Pieter M. Pil, Christine S. Chow, and Stephen J. Lippard, Proc. Natl. Acad. Sci. U. S. A., 90, 9465-9469 (1993).
A Decanuclear Mixed-Valent Manganese Complex with a High Spin Multiplicity in the Ground State. David P. Goldberg, Andrea Caneschi, and Stephen J. Lippard, J. Am. Chem. Soc., 115, 9299-9300 (1993).
Molecular Aspects of Platinum-DNA Interactions. Kenneth M. Comess and Stephen J. Lippard, In: Molecular Aspects of Anticancer Drug-DNA Interactions, Stephen Neidle, Michael J. Waring, Eds., Macmillan: London, 1, 134-168 (1993).
Intramolecular Conjugate Addition Reactions via Organozinc Compounds. Brian S. Bronk, Stephen J. Lippard, and Rick L. Danheiser, Organometallics, 12, 3340-3349 (1993).
Bioinorganic Chemistry: A Maturing Frontier. Stephen J. Lippard, Science, 261, 699-700 (1993).
Ixr1, a Yeast Protein That Binds to Platinated DNA and Confers Sensitivity to Cisplatin. Steven J. Brown, Patti J. Kellett, and Stephen J. Lippard, Science, 261, 603-605 (1993).
Proton ENDOR Identification of Bridging Hydroxide Ligands in Mixed-Valent Diiron Centers of Proteins: Methane Monooxygenase and Semimet Azidohemerythrin. Victoria J. DeRose, Katherine E. Liu, Donald M. Kurtz, Jr., Brian M. Hoffman, and Stephen J. Lippard, J. Am. Chem. Soc., 115, 6440-6441 (1993).
Stereochemical Control of Reactivity in Co(III) Alkyl Complexes of the Tropocoronand Ligand System. B. Scott Jaynes, Tong Ren, Axel Masschelein, and Stephen J. Lippard, J. Am. Chem. Soc., 115, 5589-5599 (1993).
Complexes of a Pendant Phenoxyl Radical Ligand, Including a New Model for the Ribonucleotide Reductase R2 Protein. David P. Goldberg, Stephen P. Watton, Axel Masschelein, LeAnn Wimmer, and Stephen J. Lippard, J. Am. Chem. Soc., 115, 5346-5347 (1993).
Isolation and characterization of cDNA clones encoding the Drosophila homolog of the HMG-box SSRP family that recognizes specific DNA structures. Suzanne L. Bruhn, David E. Housman, and Stephen J. Lippard, Nucleic Acids Res., 21, 1643-1646 (1993).
13C NMR Spectra of Carboxylate-Bridged Paramagnetic Dinuclear and Tetranuclear Iron Oxo Complexes. Robert H. Beer and Stephen J. Lippard, Inorg. Chem., 32, 1030-1032 (1993).
Synthesis of Polyamino Amido Derivatives of Ethidium. Michael V. Keck and Stephen J. Lippard, Tet. Lett., 34, 1415-1416 (1993).
15 Years of Reductive Coupling: What Have We Learned? Edmund M. Carnahan, John D. Protasiewicz, and Stephen J. Lippard, Acc. Chem. Res., 26, 90-97 (1993).
A Mixed-Valent Polyiron Oxo Complex That Models the Biomineralization of the Ferritin Core. Kingsley L. Taft, Georgia C. Papaefthymiou, and Stephen J. Lippard, Science, 259, 1302-1305 (1993).
Radical Clock Substrate Probes and Kinetic Isotope Effect Studies of the Hydroxylation of Hydrocarbons by Methane Monooxygenase. Katherine E. Liu, Cathy C. Johnson, Martin Newcomb, and Stephen J. Lippard, J. Am. Chem. Soc., 115, 939-947 (1993).
Mutagenicity and Genotoxicity of the Major DNA Adduct of the Antitumor Drug cis-Diamminedichloroplatinum(II). Lisa J. N. Bradley, Kevin J. Yarema, Stephen J. Lippard, and John M. Essigmann, Biochemistry, 32, 982-988 (1993).
Kinetic, Spectroscopic, and Structural Evidence for Carbene-Carbyne Intermediates in Carbyne/CO Coupling. John D. Protasiewicz, Axel Masschelein, and Stephen J. Lippard, J. Am. Chem. Soc., 115, 808-810 (1993).
1992
Fast atom bombardment and high performance tandem mass spectrometry of platinum(II) oligodeoxyribonucleotide fragments. Catherine E. Costello, Kenneth M. Comess, Adam S. Plaziak, Daniel P. Bancroft, and Stephen J. Lippard, Int. J. Mass Spectrom. Ion Processes, 122, 255-279 (1992).
Synthesis and Characterization of Seven-Coordinate Tantalum(I) and Niobium(I) Complexes with Cis Carbonyl and Alkyl Isocyanide Ligands. Edmund M. Carnahan, R. Lynn Rardin, Simon G. Bott, and Stephen J. Lippard, Inorg. Chem., 31, 5193-5201 (1992).
An intrastrand d(GpG) platinum crosslink in duplex M13 DNA is refractory to repair by human cell extracts. David E. Szymkowski, Kevin Yarema, John M. Essigmann, Stephen J. Lippard, and Richard D. Wood, Proc. Natl. Acad. Sci. U. S. A., 89, 10772-10776 (1992).
Tuning the Stereochemistry of Pentacoordinate Co(III) Halide Complexes: A Rare Case of Trigonal Bipyramidal Stereochemistry for Cobalt(III). B. Scott Jaynes, Tong Ren, Shuncheng Liu, and Stephen J. Lippard, J. Am. Chem. Soc., 114, 9670-9671 (1992).
Synthesis and DNA-Binding Properties of a Cisplatin Analogue Containing a Tethered Dansyl Group. John F. Hartwig, Pieter M. Pil, and Stephen J. Lippard, J. Am. Chem. Soc., 114, 8292-8293 (1992).
Crystallization and Preliminary X-ray Analysis of the Methane Monooxygenase Hydroxylase Protein from Methylococcus capsulatus (Bath). Amy C. Rosenzweig, Christin A. Frederick, and Stephen J. Lippard, J. Mol. Biol., 227, 583-585 (1992).
Synthesis and Structural Characterization of Low-Valent Group V Phosphine Complexes. John D. Protasiewicz, Patricia A. Bianconi, Ian D. Williams, Shuncheng Liu, Ch. Pulla Rao, and Stephen J. Lippard, Inorg. Chem., 31, 4134-4142 (1992).
Dinuclear Manganese(II) Complexes with Water and Carboxylate Bridges. Shi-Bao Yu, Stephen J. Lippard, Itzhak Shweky, and Avi Bino. Inorg. Chem., 31, 3502-3504 (1992).
Models of the Oxidized Forms of Polyiron Oxo Proteins: Synthetic Routes to (μ-oxo)bis(μ-carboxylato)diiron(III) Complexes with Neutral Monodentate and Bidentate Capping Ligands. Kingsley L. Taft, Axel Masschelein, Shuncheng Liu, Stephen J. Lippard, Diana Garfinkel-Shweky, and Avi Bino, Inorg. Chim. Acta, 198-200, 627-631 (1992).
DNA Binding Properties of cis-[Pt(NH3)(C6H11NH2)Cl2], a Metabolite of an Orally Active Platinum Anticancer Drug. John F. Hartwig and Stephen J. Lippard, J. Am. Chem. Soc., 114, 5646-5654 (1992).
Synthesis and Characterization of Trinuclear Iron(II) and Manganese(II) Carboxylate Complexes: Structural Trends in Low Valent Iron and Manganese Carboxylates. R. Lynn Rardin, Peter Poganiuch, Avi Bino, David P. Goldberg, William B. Tolman, Shuncheng Liu, and Stephen J. Lippard, J. Am. Chem. Soc., 114, 5240-5249 (1992).
Formation of Highly Functionalized Metal-Bound Acetylenes by Reductive Coupling of Carbon Monoxide and Methyl Isocyanide Ligands. Edmund M. Carnahan and Stephen J. Lippard, J. Am. Chem. Soc., 114, 4166-4174 (1992).
Replication Inhibition and Translesion Synthesis on Templates Containing Site-Specifically Placed cis-Diamminedichloroplatinum(II) DNA Adducts. Kenneth M. Comess, Judith N. Burstyn, John M. Essigmann, and Stephen J. Lippard, Biochemistry, 31, 3975-3990 (1992).
Unwinding of Supercoiled DNA by Platinum-Ethidium and Related Complexes. Michael A. Keck and Stephen J. Lippard, J. Am. Chem. Soc., 114, 3386-3390 (1992).
Specific Binding of Chromosomal Protein HMG1 to DNA Damaged by the Anticancer Drug Cisplatin. Pieter M. Pil and Stephen J. Lippard, Science, 256, 234-237 (1992).
Isolation and characterization of human cDNA clones encoding a high mobility group box protein that recognizes structural distortions to DNA caused by binding of the anticancer agent cisplatin. Suzanne L. Bruhn, Pieter M. Pil, John M. Essigmann, David E. Housman, and Stephen J. Lippard, Proc. Natl. Acad. Sci. U. S. A., 89, 2307-2311 (1992).
Linear CO-Bridged, Dinuclear Tantalum Siloxycarbyne Complexes. Raymond N. Vrtis, Simon G. Bott, and Stephen J. Lippard, Organometallics, 11, 270-277 (1992).
1991
Studies of Methane Monooxygenase and Alkane Oxidation Model Complexes. Amy C. Rosenzweig, Xudong Feng, and Stephen J. Lippard, In: Applications of Enzyme Biotechnology, Jeffery W. Kelly, Thomas O. Baldwin, Eds., Plenum Press: New York, 69-85 (1991).
Platinum DNA Chemistry. Stephen J. Lippard In: Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy , Stephen B. Howell, Ed., Plenum Press: New York, 1-12 (1991).
X-ray Absorption, Mössbauer, and EPR Studies of the Dinuclear Iron Center in the Hydroxylase Component of Methane Monooxygenase. Jane G. DeWitt, James G. Bentsen, Amy C. Rosenzweig, Britt Hedman, Jeffrey Green, Simon Pilkington, Georgia C. Papaefthymiou, Howard Dalton, Keith O. Hodgson, and Stephen J. Lippard, J. Am. Chem. Soc., 113, 9219-9235 (1991).
Synthesis of Thioether Derivatives of Ethidium Bromide. Gregory T. Whiteker and Steven J. Lippard, Tett. Lett., 32, 5019-5020 (1991).
DNA Unwinding Produced by Site-Specific Intrastrand Cross-links of the Antitumor Drug cis-Diamminedichloroplatinum(II). Steven F. Bellon, Julia H. Coleman, and Stephen J. Lippard, Biochemistry, 30, 8026-8035 (1991).
Vanadium Promoted Reductive Coupling of CO and Facile Hydrogenation to Form cis-Disiloxyethylenes. John D. Protasiewicz and Stephen J. Lippard, J. Am. Chem. Soc., 113, 6564-6570 (1991).
Monodentate Carboxylate Complexes and the Carboxylate Shift: Implications for Polymetalloprotein Structure and Function. R. Lynn Rardin, William B. Tolman, and Stephen J. Lippard, New J. Chem., 15, 417-430 (1991).
Redox Properties of the Hydroxylase Component of Methane Monooxygenase from Methylococcus capsulatus (Bath). Katherine E. Liu and Stephen J. Lippard, J. Biol. Chem., 266, 12836-12839 (1991).
A Trinuclear, Oxo-Centered Mixed-Valence Iron Complex with Unprecedented Carboxylate Coordination: [Fe3O(O2CCH3)6(TACN)]·2CHCl3. Peter Poganiuch, Shuncheng Liu, Georgia C. Papaefthymiou, and Stephen J. Lippard, J. Am. Chem. Soc., 113, 4645-4651 (1991).
Reaction Chemistry of [M(R3SiOCCOSiR3)(dmpe)2Cl] (M = Ta, Nb): Isolation and Structural Characterization of the First (Dihydroxyacetylene)metal Complexes and Removal of the Disiloxyacetylene Ligand as an Alkene. Raymond N. Vrtis, Simon G. Bott, R. Lynn Rardin, and Stephen J. Lippard, Organometallics, 10, 1364-1373 (1991).
Effects of a Bridging Dicarboxylate Ligand on the Synthesis and Physical Properties of (μ-Oxo)bis(μ-carboxylato)diiron(III) Complexes. Robert H. Beer, William B. Tolman, Simon G. Bott, and Stephen J. Lippard, Inorg. Chem., 30, 2082-2092 (1991).
Mechanistic Studies of the Reductive Coupling of Isocyanides in Seven-co-ordinate Molybdenum Complexes; X-Ray Crystal Structures of [Mo(CNBut)6] and [Mo{≡CN(But)(SiMe2But)}(CNBut)5][O3SCF3]. Edmund M. Carnahan and Stephen J. Lippard, J. Chem. Soc., Dalton Trans., 699-706 (1991).
Magnetostructural Correlations in Magnetically Coupled (μ-Oxo)diiron(III) Complexes. Sergiu M. Gorun and Stephen J. Lippard, Inorg. Chem., 30, 1625-1630 (1991).
Mechanistic Studies of a Novel Class of Trisubstituted Platinum(II) Antitumor Agents. L. Steven Hollis, Wesley I. Sundquist, Judith N. Burstyn, Wendy H. Heiger-Bernays, Steven F. Bellon, Kazi J. Ahmed, Alan R. Amundsen, Eric W. Stern, and Stephen J. Lippard, Cancer Res., 51, 1866-1875 (1991).
Synthesis and Structure of Seven-Coordinate Rhenium(III) Mixed Halo-Phosphine Isocyanide Complexes. Steve Warner, Linda K. Cheatham, Thomas H. Tulip, Ian D. Williams, and Stephen J. Lippard, Inorg. Chem., 30, 1221-1226 (1991).
Mechanistic Studies of the Reductive Coupling of Carbon Monoxide in Seven-Coordinate Niobium(I) and Tantalum(I) Dicarbonyl Complexes. Raymond N. Vrtis, Shuncheng Liu, Ch. Pulla Rao, Simon G. Bott, and Stephen J. Lippard, Organometallics, 10, 275-285 (1991).
Models of the Reduced Forms of Polyiron-Oxo Proteins: An Asymmetric, Triply Carboxylate Bridged Diiron(II) Complex and Its Reaction with Dioxygen. William B. Tolman, Shuncheng Liu, James G. Bentsen, and Stephen J. Lippard, J. Am. Chem. Soc., 113, 152-164 (1991).
1990
Reductive Coupling of Carbon Monoxide and Alkyl Isocyanide Ligands in Early Transition Metal Complexes: A Review. Raymond N. Vrtis and Stephen J. Lippard, Isr. J. Chem., 30, 331-341 (1990).
Synthesis and Structure of [Fe(OMe)2(O2CCH2Cl)]10, a Molecular Ferric Wheel. Kingsley L. Taft and Stephen J. Lippard, J. Am. Chem. Soc., 112, 9629-9630 (1990).
Enantioselective Conjugate Addition of Grignard Reagents to Enones Catalyzed by Chiral Cuprate Complexes. Kwang-Hyun Ahn, R. Bryan Klassen, and Stephen J. Lippard, Organometallics, 9, 3178-3181 (1990).
Biological Processing of DNA Modified by Platinum Compounds. Suzanne L. Bruhn, Jeffrey H. Toney, and Stephen J. Lippard, Prog. Inorg. Chem., 38, 477-516 (1990).
Molecular Structure of the Complex Formed Between the Anticancer Drug Cisplatin and d(pGpG): C2221 Crystal Form. Miquell Coll, Suzanne E. Sherman, Dan Gibson, Stephen J. Lippard, and Andrew H.-J. Wang, J. Biomol. Struct. Dyn., 8, 315-330 (1990).
Structure of Tetramethyl Reductic Acid (TMRA, 4,4,5,5-Tetramethyl-2,3-dihydroxy-2-cyclopenten-1-one), a Reductate Ligand Involved in Dioxygen Activation by Multinuclear Iron Complexes. Xudong Feng, Simon G. Bott, and Stephen J. Lippard, Acta Cryst., C46, 1671-1674 (1990).
Interaction of Platinum Antitumor Compounds with DNA. Christopher A. Lepre and Stephen J. Lippard, Nucleic Acids. Mol. Biol., 4, 9-38 (1990).
Effect of the Antitumor Drug cis-Diamminedichloroplatinum(II) and Related Platinum Complexes on Eukaryotic DNA Replication. Wendy J. Heiger-Bernays, John M. Essigmann, and Stephen J. Lippard, Biochemistry, 29, 8461-8466 (1990).
195Pt NMR Kinetic and Mechanistic Studies of cis- and trans-Diamminedichloroplatinum(II) Binding to DNA. Daniel P. Bancroft, Christopher A. Lepre, and Stephen J. Lippard, J. Am. Chem. Soc., 112, 6860-6871 (1990).
Synthesis and Characterization of the Linear Trinuclear Complexes [M(II)3(O2CCH3)6(biphme)2], M = Mn, Fe. R. Lynn Rardin, Avi Bino, Peter Poganiuch, William B. Tolman, Shuncheng Liu, and Stephen J. Lippard, Angew. Chem., Int. Ed., 29, 812-814 (1990).
μ-Hydroxobis(μ-formato)hexaaquadichromium(III), an Intermediate in the Formation of Basic Chromium Carboxylates. Petra N. Turowski, Avi Bino, and Stephen J. Lippard, Angew. Chem., Int. Ed., 29, 811-812 (1990).
Bending studies of DNA site-specifically modified by cisplatin, trans-diamminedichloroplatinum(II) and cis-[Pt(NH3)2(N3-cytosine)Cl]+. Steven F. Bellon and Stephen J. Lippard, Biophys. Chem., 35, 179-188 (1990).
Characterization of a DNA Damage-Recognition Protein from Mammalian Cells That Binds Specifically to Intrastrand d(GpG) and d(ApG) DNA Adducts of the Anticancer Drug Cisplatin. Brian A. Donahue, Marianne Augot, Steven F. Bellon, Daniel K. Treiber, Jeffrey H. Toney, Stephen J. Lippard, and John M. Essigmann, Biochemistry, 29, 5872-5880 (1990).
Reductive Coupling of Carbon Monoxide with Methyl Isocyanide in a Seven-Coordinate Niobium Complex. Edmund M. Carnahan and Stephen J. Lippard, J. Am. Chem. Soc., 112, 3230-3231 (1990).
The Coordination Chemistry of Platinum Anticancer Drugs and Related Compounds with DNA. Wesley I. Sundquist and Stephen J. Lippard, Coord. Chem. Rev., 100, 293-322 (1990).
Identification and Characterization of a Novel Linkage Isomerization in the Reaction of trans-Diamminedichloroplatinum(II) with 5'-d(TCTACGCGTTCT). Kenneth M. Comess, Catherine E. Costello, and Stephen J. Lippard, Biochemistry, 29, 2102-2110 (1990).
Synthesis, Isomer Separation, and Metal Complexation Studies of Aza- and Oxaphosphands, a Class of Hard/Soft Dinucleating Phosphine Macrocycles. Liwen Wei, Andrew Bell, Kwang-Hyun Ahn, Mark M. Holl, Steve Warner, Ian D. Williams, and Stephen J. Lippard, Inorg. Chem., 29, 825-837 (1990).
Synthesis, Characterization, and Biological Activity of cis-Diammineplatinum(II) Complexes of the DNA Intercalators 9-Aminoacridine and Chloroquine. Wesley I. Sundquist, Daniel P. Bancroft, and Stephen J. Lippard, J. Am. Chem. Soc., 112, 1590-1596 (1990).
Synthesis and Characterization of trans-[Pt(NH3)2Cl2] Adducts of d(CCTCGAGTCTCC)·d(GGAGACTCGAGG). Christopher A. Lepre, Laurent Chassot, Catherine E. Costello, and Stephen J. Lippard, Biochemistry, 29, 811-823 (1990).
Phosphate Ester and Phosphinate Binding to the (μ-Oxo)diiron(III) Core: Synthesis and Characterization of [Fe2O{O2P(OC6H5)2}2(HBpz3)2] and [Fe2O{O2P(C6H5)2}2(HBpz3)2]. Petra N. Turowski, William H. Armstrong, Mary E. Roth, and Stephen J. Lippard, J. Am. Chem. Soc., 112, 681-690 (1990).
1989
A General Method for Assembling (μ-Oxo)bis(μ-carboxylato)diiron(III) Complexes with Labile Terminal Sites Using a Bridging Dicarboxylate Ligand. Robert H. Beer, William B. Tolman, Simon G. Bott, and Stephen J. Lippard, Inorg. Chem., 28, 4557-4558 (1989).
Structure of 1-[(R)-α-Methylbenzylamino]-7-[(R)-α-methylbenzylimino]-1,3,5-cycloheptatriene, H(CHIRAMT), a Ligand used for Enantioselective Conjugate Addition Cuprate Catalysis. Simon G. Bott, Kwang-Hyun Ahn, and Stephen J. Lippard, Acta Cryst., C45, 1738-1740 (1989).
Isolation of cDNAs encoding a human protein that binds selectively to DNA modified by the anticancer drug cis-diamminedichloroplatinum(II). Jeffrey H. Toney, Brian A. Donahue, Patti J. Kellett, Suzanne L. Bruhn, John M. Essigmann, and Stephen J. Lippard, Proc. Natl. Acad. Sci. U. S. A., 86, 8328-8332 (1989).
Self-Assembly and Dioxygen Reactivity of an Asymmetric, Triply Bridged Diiron(II) Complex with Imidazole Ligands and an Open Coordination Site. William B. Tolman, Avi Bino, and Stephen J. Lippard, J. Am. Chem. Soc., 111, 8522-8523 (1989).
Synthesis and Properties of a Novel Oxo-Bridged Dinuclear Iron(III) Complex Containing Only Oxygen Donating Ligands. Xudong Feng, Simon G. Bott, and Stephen J. Lippard, J. Am. Chem. Soc., 111, 8046-8047 (1989).
Heptadecanuclear Mixed Metal Iron Oxo-Hydroxo Complexes, [Fe16MO10(OH)10(O2CPh)20], M = Mn or Co, Structurally Comprised of Two Fragments Derived from [Fe11O6(OH)6(O2CPh)15]. Wolfgang Micklitz and Stephen J. Lippard, J. Am. Chem. Soc., 111, 6856-6858 (1989).
Synthesis and Structures of New Six-Coordinate 16- and 17-Valence-Electron Rhenium Phosphine Complexes and Their Use in Preparing Seven-Coordinate Mixed RNC/CO Rhenium(III) Compounds. Steve Warner and Stephen J. Lippard, Inorg. Chem., 28, 3008-3013 (1989).
A Dinucleating Hexaimidazole Ligand and Its Dicopper(II) Methanol Inclusion Complex. William B. Tolman, R. Lynn Rardin, and Stephen J. Lippard, J. Am. Chem. Soc., 111, 4532-4533 (1989).
Isomerization of Binuclear Amidate-Bridged Platinum(II) Amine Complexes: A 195Pt NMR Investigation. Thomas V. O'Halloran and Stephen J. Lippard, Inorg. Chem., 28, 1289-1295 (1989).
cis-Diammineplatinum α-Pyridone Blue. Pradip K. Mascharak and Stephen J. Lippard, Inorg. Synth., 25, 94-97 (1989).
Synthesis, Characterization, and DNA-Binding Properties of (1,2-Diaminoethane)platinum(II) Complexes Linked to the DNA Intercalator Acridine Orange by Trimethylene and Hexamethylene Chains. Bruce E. Bowler, Kazi J. Ahmed, Wesley I. Sundquist, L. Steven Hollis, Edward E. Whang, and Stephen J. Lippard, J. Am. Chem. Soc., 111, 1299-1306 (1989).
Synthesis, Structure, and Reactions of Rhenium Aminocarbyne Complexes Formed from [ReCl2(CNR)3(PMePh2)2]+ (R = t-Bu or Me) Cations under Reductive Coupling Conditions. Steve Warner and Stephen J. Lippard, Organometallics, 8, 228-236 (1989).
Characterization of a Novel μ4-Peroxide Tetrairon Unit of Possible Relevance to Intermediates in Metal-Catalyzed Oxidations of Water to Dioxygen. Wolfgang Micklitz, Simon G. Bott, James G. Bentsen, and Stephen J. Lippard, J. Am. Chem. Soc., 111, 372-374 (1989).
1988
DNA Promotes the Reaction of cis-Diamminedichloroplatinum(II) with the Exocyclic Amino Groups of Ethidium Bromide. Wesley I. Sundquist, Daniel P. Bancroft, Laurent Chassot, and Stephen J. Lippard, J. Am. Chem. Soc., 110, 8559-8560 (1988).
Synthesis and Stabilization of Tantalum-Coordinated Dihydroxyacetylene from Two Reductively Coupled Carbon Monoxide Ligands. Raymond N. Vrtis, Ch. Pulla Rao, Simon G. Bott, and Stephen J. Lippard, J. Am. Chem. Soc., 110, 7564-7566 (1988).
Crystal and Molecular Structure of cis-[Pt(NH3)2{d(pGpG)}], the Principal Adduct Formed by cis-Diamminedichloroplatinum(II) with DNA. Suzanne E. Sherman, Dan Gibson, Andrew H.-J. Wang, and Stephen J. Lippard, J. Am. Chem. Soc., 110, 7368-7381 (1988).
A Novel Hexairon(III) Aggregate Prepared from a Basic Iron(III) Benzoate. Possible Building Blocks in Ferritin Core Formation. Wolfgang Micklitz and Stephen J. Lippard, Inorg. Chem., 27, 3067-3069 (1988).
Chemical and Biological Studies of the Major DNA Adduct of cis-Diamminedichloroplatinum(II), cis-[Pt(NH3)2{d(GpG)}], Built into a Specific Site in a Viral Genome. Lisa J. Naser, Ann L. Pinto, Stephen J. Lippard, and John M. Essigmann, Biochemistry, 27, 4357-4367 (1988).
The major adduct of the antitumor drug cis-diamminedichloroplatinum(II) with DNA bends the duplex by ≈40° toward the major groove. Janet A. Rice, Donald M. Crothers, Ann L. Pinto, and Stephen J. Lippard, Proc. Natl. Acad. Sci. U. S. A., 85, 4158-4161 (1988).
Synthesis and Reactivity of Binuclear Tropocoronand and Related Organocopper(I) Complexes. Catalytic Enantioselective Conjugate Addition of Grignard Reagents to 2-Cyclohexen-1-one. Gilberto M. Villacorta, Ch. Pulla Rao, and Stephen J. Lippard, J. Am. Chem. Soc., 110, 3175-3182 (1988).
Synthesis and Characterization of [d(ApGpGpCpCpT)]2 and Its Adduct with the Anticancer Drug cis-Diamminedichloroplatinum(II). John P. Caradonna and Stephen J. Lippard, Inorg. Chem., 27, 1454-1466 (1988).
Carbynes Generated From Metal Carbonyl and Isocyanide Complexes; Intermediates in the Reductive Coupling of CO and CNR Ligands. Raymond N. Vrtis, Ch. Pulla Rao, Steve Warner, and Stephen J. Lippard, J. Am. Chem. Soc., 110, 2669-2670 (1988).
Extrachromosomal Probes with Site-Specific Modifications: Construction of Defined DNA Substrates for Repair and Mutagenesis Studies. Lisa J. Naser, Ann L. Pinto, Stephen J. Lippard, and John M. Essigmann, In: DNA Repair: A Laboratory Manual of Research Procedures, Vol. 3, Errol C. Frieberg, Philip C. Hanawalt, Eds., Marcel Dekker: New York, 205-127 (1988).
Oxo-Bridged Polyiron Centers in Biology and Chemistry. Stephen J. Lippard, Angew. Chem., Int. Ed., 27, 344-361 (1988).
Structural Characterization by EXAFS Spectroscopy of the Binuclear Iron Center in Protein A of Methane Monooxygenase from Methylococcus capsulatus (Bath). Agneta Ericson, Britt Hedman, Keith O. Hodgson, Jeffrey Green, Howard Dalton, James G. Bentsen, Robert H. Beer, and Stephen J. Lippard, J. Am. Chem. Soc., 110, 2330-2332 (1988).
Synthesis, Structure, and Characterization of the Tetranuclear Iron(III) Oxo Complex [Fe4O2(BICOH)2(BICO)2(O2CPh)4]Cl2. Sergiu M. Gorun and Stephen J. Lippard, Inorg. Chem., 27, 149-156 (1988).
Synthesis, Structure Determination, and Stereoisomerism of Dirhodium(I) Tetracarbonyl Tropocoronand Complexes. Gilberto M. Villacorta and Stephen J. Lippard, Inorg. Chem., 27, 144-149 (1988).
1987
Monoclonal antibodies to DNA modified with cis or trans-diamminedichloroplatinum(II). Wesley I. Sundquist, Stephen J. Lippard, and B. David Stollar, Proc. Natl. Acad. Sci. U. S. A., 84, 8225-8229 (1987).
Synthesis and Characterization of (μ-Hydroxo)bis(μ-acetato)diiron(II) and (μ-oxo)bis(μ-acetato)diiron(III) 1,4,7-Trimethyl-1,4,7-triazacyclononane Complexes as Models for Binuclear Iron Centers in Biology; Properties of the Mixed Valence Diiron(II,III) Species. JudithAnn R. Hartman, R. Lynn Rardin, Phalguni Chaudhuri, Klaus Pohl, Karl Wieghardt, Bernhard Nuber, Johannes Weiss, Georgia C. Papaefthymiou, Richard B. Frankel, and Stephen J. Lippard, J. Am. Chem. Soc., 109, 7387-7396 (1987).
Dicopper(I) Carbonyl Tropocoronands. Preparation, Structural Characteristics, and Reactivity of Neutral Binuclear Cu-CO Macrocyclic Compounds. Gilberto M. Villacorta and Stephen J. Lippard, Inorg. Chem., 26, 3672-3676 (1987).
Alkyne-Bridged Dicopper(I) Complexes of the Tropocoronand Macrocycles. Gilberto M. Villacorta, Dan Gibson, Ian D. Williams, Edward Whang, and Stephen J. Lippard, Organometallics, 6, 2426-2431 (1987).
Tetranuclear Iron-Oxo Complexes. Synthesis, Structure, and Properties of Species Containing the Nonplanar {Fe4O2}8+ Core and Seven Bridging Carboxylate Ligands. William H. Armstrong, Mary E. Roth, and Stephen J. Lippard, J. Am. Chem. Soc., 109, 6318-6326 (1987).
Structural Aspects of Platinum Anticancer Drug Interactions with DNA. Suzanne E. Sherman and Stephen J. Lippard, Chem. Rev., 87, 1153-1181 (1987).
Synthesis and 1H NMR Spectroscopic Characterization of trans-[Pt(NH3)2-{d(ApGpGpCpCpT)-N7-A(1),N7-G(3)}]. Christopher A. Lepre, Kenneth G. Strothkamp, and Stephen J. Lippard, Biochemistry, 26, 5651-5657 (1987).
Reductive Coupling of Carbon Monoxide Ligands to Form Coordinated Bis(trimethylsiloxy)ethyne in Seven-Coordinate Niobium(I) and Tantalum(I) [M(CO)2(dmpe)2Cl] Complexes. Patricia A. Bianconi, Raymond N. Vrtis, Ch. Pulla Rao, Ian D. Williams, Mary P. Engeler, and Stephen J. Lippard, Organometallics, 6, 1968-1977 (1987).
Molecular Mechanics Modeling of Oligonucleotide Adducts of the Antitumor Drug cis-Diamminedichloroplatinum(II). Jiří Kozelka, Sharon Archer, Gregory A. Petsko, Stephen J. Lippard, and Gary J. Quigley, Biopolymers, 26, 1245-1271 (1987).
Synthesis and NMR Structural Studies of the Adduct of trans-Diamminedichloroplatinum(II) with the DNA Fragment d(GpCpG). Dan Gibson and Stephen J. Lippard, Inorg. Chem., 26, 2275-2279 (1987).
Synthesis, Structure, and Magnetic and Mössbauer Properties of Mononuclear and Asymmetric, Oxo-Bridged Trinuclear Iron(III) Complexes of a New Polyimidazole Ligand. Sergiu M. Gorun, Georgia C. Papaefthymiou, Richard B. Frankel, and Stephen J. Lippard, J. Am. Chem. Soc., 109, 4244-4255 (1987).
Chemistry and molecular biology of platinum anticancer drugs. Stephen J. Lippard, Pure Appl. Chem., 59, 731-742 (1987).
Synthesis, Structure, and Properties of an Undecairon(III) Oxo-Hydroxo Aggregate: An Approach to the Polyiron Core in Ferritin. Sergiu M. Gorun, Georgia C. Papaefthymiou, Richard B. Frankel, and Stephen J. Lippard, J. Am. Chem. Soc., 109, 3337-3348 (1987).
Solvolysis Reactions of cis- and trans-Diamminedichloroplatinum(II) in Dimethyl Sulfoxide. Structural Characterization and DNA Binding of trans-[Pt(NH3)2(Me2SO)Cl]+. Wesley I. Sundquist, Kazi J. Ahmed, L. Steven Hollis, and Stephen J. Lippard, Inorg. Chem., 26, 1524-1528 (1987).
Multiple Heavy-atom Reagents for Macromolecular X-ray Structure Determination. Thomas V. O'Halloran, Stephen J. Lippard, Timothy J. Richmond, and Aaron Klug, J. Mol. Biol., 194, 705-712 (1987).
Synthesis, Structure Determination, and Electronic Structure Characterization of Two Mixed-Valence Tetranuclear Platinum Blues with Bridging α-Pyridonate or 1-Methyluracilate Ligands. Thomas V. O'Halloran, Pradip K. Mascharak, Ian D. Williams, Michael M. Roberts, and Stephen J. Lippard, Inorg. Chem., 26, 1261-1270 (1987).
Binuclear Manganese(III) Complexes of Potential Biological Significance. John E. Sheats, Roman S. Czernuszewicz, G. Charles Dismukes, Arnold L. Rheingold, Vasili Petrouleas, JoAnne Stubbe, William H. Armstrong, Robert H. Beer, and Stephen J. Lippard, J. Am. Chem. Soc., 109, 1435-1444 (1987).
1986
Aza- and Oxaphosphands, a New Class of Hard/Soft Binucleating Phosphine Macrocycles. Liwen Wei, Andrew Bell, Steve Warner, Ian D. Williams, and Stephen J. Lippard, J. Am. Chem. Soc., 108, 8302-8303 (1986).
Site-Specifically Platinated DNA, a New Probe of the Biological Activity of Platinum Anticancer Drugs. Ann L. Pinto, Lisa J. Naser, John M. Essigmann, and Stephen J. Lippard, J. Am. Chem. Soc., 108, 7405-7407 (1986).
Tropocoronands: a versatile macrocyclic ligand system for mononuclear and binuclear metal complexes. Gilberto M. Villacorta and Stephen J. Lippard, Pure Appl. Chem., 58, 1477-1484 (1986).
EXAFS Studies of Binuclear Iron Complexes as Models for Hemerythrin and Related Proteins. Britt Hedman, Man Sung Co, William H. Armstrong, Keith O. Hodgson, and Stephen J. Lippard, Inorg. Chem., 25, 3708-3711 (1986).
Reductive Coupling of Isocyanide Ligands in Seven-Coordinate Molybdenum(II) Mixed Isocyanide-Bipyridine Complexes. Steve Warner and Stephen J. Lippard, Organometallics, 5, 1716-1725 (1986).
Modulation of Platinum Antitumor Drug Binding to DNA by Linked and Free Intercalators. Bruce E. Bowler and Stephen J. Lippard, Biochemistry, 25, 3031-3038 (1986).
High-Salt and Low-Salt Models for Kinked Adducts of cis-Diamminedichloroplatinum(II) with Oligonucleotide Duplexes. Jiří Kozelka, Gregory A. Petsko, Gary J. Quigley, and Stephen J. Lippard, Inorg. Chem., 25, 1075-1077 (1986).
Binding of cis- and trans-Diamminedichloroplatinum(II) to Deoxyribonucleic Acid Exposes Nucleosides As Measured Immunochemically with Anti-Nucleoside Antibodies. Wesley I. Sundquist, Stephen J. Lippard, and B. David Stollar, Biochemistry, 25, 1520-1524 (1986).
Synthesis, Structure, and 195Pt NMR Solution Studies of a Reactive Binuclear Platinum(III) Complex: [Pt2(en)2(C5H4NO)2(NO2)(NO3)](NO3)2·0.5H2O. Thomas V. O'Halloran, Michael M. Roberts, and Stephen J. Lippard, Inorg. Chem., 25, 957-964 (1986).
The bioinorganic chemistry of rust. Stephen J. Lippard, Chem. Br., 22, 221-228 (1986).
A new synthetic approach to the ferritin core uncovers the soluble iron(III) oxo-hydroxo aggregate [Fe11O6(OH)6(O2CPh)15]. Sergiu M. Gorun and Stephen J. Lippard, Nature, 319, 666-668 (1986).
Preparation and Structural Characterization of a Novel Hexanuclear Complex of Platinum(II) with 2-Aminoethanethiolate. Dan Gibson and Stephen J. Lippard, Inorg. Chem., 25, 219-222 (1986).
Reductive Coupling of Two Carbon Monoxide Ligands to Form a Coordinated Alkyne. Patricia A. Bianconi, Ian D. Williams, Mary P. Engeler, and Stephen J. Lippard, J. Am. Chem. Soc., 108, 311-313 (1986).
1985
In Vivo Effects of cis- and trans-Diamminedichloroplatinum(II) on SV40 Chromosomes: Differential Repair, DNA-Protein Cross-Linking, and Inhibition of Replication. Richard B. Ciccarelli, Mark J. Solomon, Alexander Varshavsky, and Stephen J. Lippard, Biochemistry, 24, 7533-7540 (1985).
Dicopper(I) Tropocoronands: Synthesis, X-ray Crystal Structure, and Spectral Properties of Neutral Binuclear Copper(I) Complexes Bridged by Symmetrically Substituted Alkynes. Gilberto M. Villacorta, Dan Gibson, Ian D. Williams, and Stephen J. Lippard, J. Am. Chem. Soc., 107, 6732-6734 (1985).
Copper(II) Tropocoronands: Synthesis, Structure, and Properties of Mononuclear Complexes. William M. Davis, Arie Zask, Koji Nakanishi, and Stephen J. Lippard, Inorg. Chem., 24, 3737-3743 (1985).
Tropocoronands as Binucleating Ligands. Synthesis, Structure, and Properties of a (μ-acetato)(μ-methoxo)dicopper(II) Derivative. William M. Davis and Stephen J. Lippard, Inorg. Chem., 24, 3688-3691 (1985).
X-ray Structure of the Major Adduct of the Anticancer Drug Cisplatin with DNA: cis-[Pt(NH3)2{d(pGpG)}]. Suzanne E. Sherman, Dan Gibson, Andrew H.-J. Wang, and Stephen J. Lippard, Science, 230, 412-417 (1985).
Binding of the Antitumor Drug cis-Diamminedichloroplatinum(II) (Cisplatin) to DNA. Ann L. Pinto and Stephen J. Lippard, Biochim. Biophys. Acta, 780, 167-180 (1985).
Sequence-dependent termination of in vitro DNA synthesis by cis- and trans-diamminedichloroplatinum(II). Ann L. Pinto and Stephen J. Lippard, Proc. Natl. Acad. Sci. U. S. A., 82, 4616-4619 (1985).
Synthesis, Structure, and Magnetic Properties of an Asymmetric μ3-Oxotriiron(III) Complex: A New Type of {Fe3O}7+ Core. Sergiu M. Gorun and Stephen J. Lippard, J. Am. Chem. Soc., 107, 4568-4570 (1985).
Electronic and Vibrational Spectroscopic Analysis of the (μ-Oxo)bis(μ-carboxylato)diiron(III) Core: A Study of [Fe2O(O2CCH3)2(TACN)2]2+. Alan Spool, Ian D. Williams, and Stephen J. Lippard, Inorg. Chem., 24, 2156-2162 (1985).
Molecular Mechanics Calculations on cis-[Pt(NH3)2{d(GpG)}] Adducts in Two Oligonucleotide Duplexes. Jiří Kozelka, Gregory A. Petsko, Stephen J. Lippard, and Gary J. Quigley, J. Am. Chem. Soc., 107, 4079-4081 (1985).
Stereochemical and Electronic Spin State Tuning of the Metal Center in the Nickel(II) Tropocoronands. William M. Davis, Michael M. Roberts, Arie Zask, Koji Nakanishi, Tetsuo Nozoe, and Stephen J. Lippard, J. Am. Chem. Soc., 107, 3864-3870 (1985).
Carboxylate Bridge Exchange Reactions in the {Fe2O(O2CR)2}2+ Core. Synthesis, Structure and Properties of Phosphodiester-Bridged Complexes. William H. Armstrong and Stephen J. Lippard, J. Am. Chem. Soc., 107, 3730-3731 (1985).
The Chemistry of Platinum in the +3 Oxidation State. Thomas V. O'Halloran and Stephen J. Lippard, Isr. J. Chem., 25, 130-137 (1985).
Convenient, High-Yield Synthesis of (Et4N)2[Fe2OCl6]. William H. Armstrong and Stephen J. Lippard, Inorg. Chem., 24, 981-982 (1985).
Synthesis and Reactions of Seven-Coordinate Technetium and Rhenium Alkyl Isocyanide Complexes. James P. Farr, Michael J. Abrams, Catherine E. Costello, Alan Davison, Stephen J. Lippard, and Alun G. Jones, Organometallics, 4, 139-142 (1985).
1984
Crystal Structures of Two Titanium Tartrate Asymmetric Epoxidation Catalysts. Ian D. Williams , Steven F. Pedersen , K. Barry Sharpless, and Stephen J. Lippard, J. Am. Chem. Soc., 106, 6430–6431 (1984)
Characterization of a Platinum Pyrimidine Blue: Synthesis, Structure, and Physical Properties of cis-Diammineplatinum 1-Methyluracil Blue. Pradip K. Mascharak, Ian D. Williams, and Stephen J. Lippard, J. Am. Chem. Soc., 106, 6428-6430 (1984).
Correlation between Metal-Metal Distances and Optical Spectroscopy in the Platinum Blues: Synthesis, Crystal Structure, and Electronic Spectrum of Ethylenediamineplatinum α-Pyridone Blue. Thomas V. O'Halloran, Michael M. Roberts, and Stephen J. Lippard, J. Am. Chem. Soc., 106, 6427-6428 (1984).
A Molecule Containing the OWOWO Unit. Synthesis, Structure, and Spectroscopy of W2O3(CH2CMe3)6. Irene Feinstein-Jaffe, Dan Gibson, Stephen J. Lippard, Richard R. Schrock, and Alan Spool, J. Am. Chem. Soc., 106, 6305-6310 (1984).
Synthesis and DNA Binding and Photonicking Properties of Acridine Orange Linked by a Polymethylene Tether to (1,2-Diaminoethane)dichloroplatinum(II). Bruce E. Bowler, L. Steven Hollis, and Stephen J. Lippard, J. Am. Chem. Soc., 106, 6102-6104 (1984).
Electronic Structure and Optical Spectrum of cis-Diammineplatinum α-Pyridone Blue: Metal-Metal Bonding and Charge Transfer in a Four-Atom Pt(2.25) Chain. Alvin P. Ginsberg, Thomas V. O'Halloran, Phillip E. Fanwick, L. Steven Hollis, and Stephen J. Lippard, J. Am. Chem. Soc., 106, 5430-5439 (1984).
Unusual Redox and Chemical Properties of a Sterically Constrained N3CuII Center. Preparation, Structure, and Solution Studies of (Nitrato)(1,4,7-triazacyclododecane)copper(II) Nitrate. Harald Gampp, Michael M. Roberts, and Stephen J. Lippard, Inorg. Chem., 23, 2793-2798 (1984).
Reversible Protonation of the Oxo Bridge in a Hemerythrin Model Compound. Synthesis, Structure, and Properties of (μ-Hydroxo)bis(μ-acetato)bis[hydrotris(1-pyrazolyl)borato]diiron(III), [(HB(pz)3)Fe(OH)(O2CCH3)2Fe(HB(pz)3]+. William H. Armstrong and Stephen J. Lippard, J. Am. Chem. Soc., 106, 4632-4633 (1984).
Synthesis and structure of [(η5-C5H5)Nb(CNCMe3)4Cl][NbOCl4(THF)]·THF. Helen C. Aspinall, Michael M. Roberts, and Stephen J. Lippard, Inorg. Chem., 23, 1782-1784 (1984).
Assembly and Characterization of an Accurate Model for the Diiron Center in Hemerythrin. William H. Armstrong, Alan Spool, Georgia C. Papaefthymiou, Richard B. Frankel, and Stephen J. Lippard, J. Am. Chem. Soc., 106, 3653-3667 (1984).
Magnetic, ESR, Electrochemical, and Potentiometric Titration Studies of the Imidazolate-Bridged Dicopper(II) Ion in a Binucleating Macrocycle. Peter K. Coughlin and Stephen J. Lippard, Inorg. Chem., 23, 1446-1451 (1984).
Thiocyanate Cleaves the Imidazolate-Bridged Dicopper(II) Center in a Binucleating Macrocycle To Form [Cu2(SCN)4⊂A']. Model Chemistry for Superoxide Dismutase. Andrea E. Martin and Stephen J. Lippard, J. Am. Chem. Soc., 106, 2579-2583 (1984).
Copper(II) Chemistry in Hexaaza Binucleating Macrocycles: Hydroxide and Acetate Derivatives. Peter K. Coughlin and Stephen J. Lippard, J. Am. Chem. Soc., 106, 2328-2336 (1984).
Synthesis and Structure of the Imidazolate-Bridged Dicopper(II) Ion in Two Binucleating Macrocycles. Peter K. Coughlin, Andrea E. Martin, John C. Dewan, Ei-Ichi Watanabe, John E. Bulkowski, Jean-Marie Lehn, and Stephen J. Lippard, Inorg. Chem., 23, 1004-1009 (1984).
Stereochemistry of Imidazolate-Bridged Copper(II) Complexes: [Cu2bpim(im)]2(NO3)4·3H2O, C44H50Cu4N20O15, [Cu(pip)]2(im)(NO3)3·2.5H2O, C29H34Cu2N11O11.5, [Cu(pmdt)]2(2-Meim)(ClO4)3, C22H51Cl3Cu2N8O12, and [Cu(pmdt)]2(Bzim)(ClO4)3·H2O, C25H53Cl3Cu2N8O13. Gary Kolks and Stephen J. Lippard, Acta Cryst., C40, 261-271 (1984).
Chemical and Biological Studies of cis-Diamminedichloroplatinum(II) Binding to DNA. John P. Caradonna and Stephen J. Lippard In: Platinum Coordination Complexes in Cancer Chemotherapy, Miles P. Hacker, Edwin. B. Douple and Irwin H. Krakoff, Eds., Martinus Nijhoff: Boston, 14-26 (1984).
1983
Synthesis and Structures of Platinum(III) Complexes of α-Pyridone, [X(NH3)2-Pt(C5H4NO)2Pt(NH3)2X](NO3)2·nH2O (X- = Cl-, NO2-, Br-). L. Steven Hollis, Michael M. Roberts, and Stephen J. Lippard, Inorg. Chem., 22, 3637-3644 (1983).
Alteration and activation of sequence-specific cleavage of DNA by bleomycin in the presence of the antitumor drug cis-diamminedichloroplatinum(II). Pradip K. Mascharak, Yukio Sugiura, June Kuwahara, Tadashi Suzuki, and Stephen J. Lippard, Proc. Natl. Acad. Sci. U. S. A., 80, 6795-6798 (1983).
Reactions of Homoleptic (Alkyl isocyanide)molybdenum(II) Cations [Mo(CNR)7]2+ with 2,2'-Bipyridine and Related Ligands (N-N). Substitution Chemistry and Dealkylation to Form Cyano-Bridged Complexes of the Type [{Mo(CNCMe3)4(N-N)}2(μ-CN)](PF6)3. Andrew Bell, Stephen J. Lippard, Michael Roberts, and Richard A. Walton, Organometallics, 2, 1562-1572 (1983).
Further Studies of Seven-Coordinate Complexes with Stoichiometry (Bidentate ligand)pentakis(unidentate ligand)metal. Crystal Structure of [Mo(dppm)L5](PF6)2, with L = Cyclohexyl Isocyanide. Peter W. R. Corfield, John C. Dewan, and Stephen J. Lippard, Inorg. Chem., 22, 3424-3429 (1983).
Use of Antibodies to Probe the Stereochemistry of Antitumor Platinum Drug Binding to Deoxyribonucleic Acid. Stephen J. Lippard, H. Michael Ushay, Carolyn M. Merkel, and Miriam C. Poirier, Biochemistry, 22, 5165-5168 (1983).
Mononuclear Complexes of cis-Diammineplatinum(II) and -(IV) with α-Pyridone. Structures of cis-[Pt(NH3)2(C5H4NOH)2]Cl2, mer-[Pt(NH3)2(C5H4NO)Cl3], and cis-[Pt(NH3)2(C5H4NOH)Cl](NO3). L. Steven Hollis and Stephen J. Lippard, Inorg. Chem., 22, 2708-2713 (1983).
Redox Properties of cis-Diammineplatinum α-Pyridone Blue and Related Complexes. Synthesis, Structure, and Electrochemical Behavior of cis-Diammineplatinum(III) Dimers with Bridging α-Pyridonate Ligands. L. Steven Hollis and Stephen J. Lippard, Inorg. Chem., 22, 2605-2614 (1983).
Reaction of α-Pyridone with Diaquo(ethylenediamine)platinum(II). Synthesis and Structure of the Head-to-Head Isomer of Bis(μ-2-pyridonato-N,O)bis[(ethylenediamine)platinum(II)] Nitrate. L. Steven Hollis and Stephen J. Lippard, Inorg. Chem., 22, 2600-2604 (1983).
(μ-Oxo)bis(μ-acetato)bis(tri-1-pyrazolylborato)diiron(III), [(HBpz3)FeO-(CH3CO2)2Fe(HBpz3)]: Model for the Binuclear Iron Center of Hemerythrin. William H. Armstrong and Stephen J. Lippard, J. Am. Chem. Soc., 105, 4837-4838 (1983).
Aqueous Chemistry of (2,2',2"-Terpyridine)gold(III). Preparation and Structures of [Au(terpy)Cl]Cl2·3H2O and the Mixed-Valence Au(I)-Au(III) Salt, [Au(terpy)Cl]2[AuCl2]3[AuCl4]. L. Steven Hollis and Stephen J. Lippard, J. Am. Chem. Soc., 105, 4293-4299 (1983).
Synthesis, Structure, and 195Pt NMR Studies of Binuclear Complexes of cis-Diammineplatinum(II) with Bridging α-Pyridonate Ligands. L. Steven Hollis and Stephen J. Lippard, J. Am. Chem. Soc., 105, 3494-3503 (1983).
Ethidium Bromide Alters the Binding Mode of cis-Diamminedichloroplatinum(II) to pBR322 DNA. Carolyn M. Merkel and Stephen J. Lippard, Cold Spring Harbor Symp. Quant. Biol., 47, 355-360 (1983).
195Pt NMR Investigation of the Head-to-Head to Head-to-Tail Isomerization of α-Pyridonate-Bridged Ethylenediamineplatinum(II) Dimer. Thomas V. O'Halloran and Stephen J. Lippard, J. Am. Chem. Soc., 105, 3341-3342 (1983).
Geometric Isomerism in Seven-Coordinate Tungsten(II) Mixed Carbonyl-Iodide-tert-Butyl Isocyanide Complexes. John C. Dewan, Michael M. Roberts, and Stephen J. Lippard, Inorg. Chem., 22, 1529-1533 (1983).
Copper(II) Chemistry in Binucleating Macrocycles. Andrea E. Martin and Stephen J. Lippard, In: Copper Coordination Chemistry: Biochemical and Inorganic Perspectives, Kenneth D. Karlin, Jon A. Zubieta, Eds., Adenine Press: New York, 395-408 (1983).
Tropocoronands, a New Class of Metal-Complexing Macrocycles Derived from Aminotroponeiminates. Seichi Imajo, Koji Nakanishi, Michael Roberts, Stephen J. Lippard, and Tetsuo Nozoe, J. Am. Chem. Soc., 105, 2071-2073 (1983).
Structural Chemistry of Platinum-DNA Adducts. Thomas D. Tullius, H. Michael Ushay, Carolyn M. Merkel, John P. Caradonna, and Stephen J. Lippard, In: Platinum, Gold, and Other Metal Chemotherapeutic Agents, Stephen J. Lippard, Ed., ACS Symp. Ser., 209, 51-74 (1983).
Reinvestigation of 18-Crown-6 Ether/Potassium Superoxide Solutions in Me2SO. Harald Gampp and Stephen J. Lippard, Inorg. Chem., 22, 357-358 (1983).
A Theoretical Prescription for Reductive Coupling of CO or CNR Ligands. Roald Hoffmann, Charles N. Wilker, Stephen J. Lippard, Joseph L. Templeton, and Douglas C. Brower, J. Am. Chem. Soc., 105, 146-147 (1983).
1982
A pH-Dependent Superoxide Dismutase Activity for Zinc-free Bovine Erythrocuprein. Reexamination of the Role of Zinc in the Holoprotein. Michael W. Pantoliano, Joan S. Valentine, Allan R. Burger, and Stephen J. Lippard, J. Inorg. Biochem., 17, 325-341 (1982).
New Chemistry of an Old Molecule: cis-[Pt(NH3)2Cl2]. Stephen J. Lippard, Science, 218, 1075-1082 (1982).
Chemistry of the Imidazolate-Bridged Bimetallic Center in the Cu-Zn Superoxide Dismutase and Its Model Compounds. Kenneth G. Strothkamp and Stephen J. Lippard, Acc. Chem. Res., 15, 318-326 (1982).
Antibodies elicited against cis-diamminedichloroplatinum(II)-modified DNA are specific for cis-diamminedichloroplatinum(II)-DNA adducts formed in vivo and in vitro. Miriam C. Poirier, Stephen J. Lippard, Leonard A. Zwelling, H. Michael Ushay, Donna Kerrigan, Curtis C. Thill, Regina M. Santella, Dezider Grunberger, and Stuart H. Yuspa, Proc. Natl. Acad. Sci. U. S. A., 79, 6443-6447 (1982).
The Antitumor Drug cis-[Pt(NH3)2Cl2] Forms an Intrastrand d(GpG) Cross-Link upon Reaction with [d(ApGpGpCpCpT)]2. John P. Caradonna, Stephen J. Lippard, Michael J. Gait, and Mohinder Singh, J. Am. Chem. Soc., 104, 5793-5795 (1982).
Binding of [(dien)PtCl]Cl to poly(dG-dC)·poly(dG-dC) facilitates the B→Z conformational transition. H. Michael Ushay, Regina M. Santella, John P. Caradonna, Dezider Grunberger, and Stephen J. Lippard, Nucleic Acids Res., 10, 3573-3588 (1982).
Ethidium bromide changes the nuclease-sensitive DNA binding sites of the antitumor drug cis-diamminedichloroplatinum(II). Thomas D. Tullius and Stephen J. Lippard, Proc. Natl. Acad. Sci. U. S. A., 79, 3489-3492 (1982).
Effect of Axial Ligands on the Platinum-Platinum Bond in Binuclear α-Pyridonate-Bridged Platinum(III) Complexes. Structures of [X(NH3)2Pt(C5H4NO)2Pt(NH3)2X](NO3)2·H2O, X = NO3, NO2. L. Steven Hollis and Stephen J. Lippard, Inorg. Chem., 21, 2116-2117 (1982).
Electrochemical Studies of Seven-Coordinate Isocyanide Complexes of Molybdenum(II) and Tungsten(II). Carl Caravana, Christen M. Giandomenico, and Stephen J. Lippard, Inorg. Chem., 21, 1860-1863 (1982).
Stereochemical Studies on Seven-Coordinate Complexes with Stoichiometry (Bidentate ligand)pentakis(unidentate ligand)metal. Crystal Structures of [Mo(dppm)(CNCH3)5](PF6)2 and [Mo(dppe)(CNCH3)5](PF6)2. John C. Dewan, Thomas E. Wood, Richard A. Walton, and Stephen J. Lippard, Inorg. Chem., 21, 1854-1859 (1982).
Structure of a Homoleptic Seven-Coordinate Molybdenum(II) Aryl Isocyanide Complex, [Mo(CNPh)7](PF6)2. John C. Dewan and Stephen J. Lippard, Inorg. Chem., 21, 1682-1684 (1982).
Reductive Coupling of Coordinated Alkyl Isocyanides in Seven-Coordinate Molybdenum(II) and Tungsten(II) Complexes. Removal of the Coupled Ligand as an Oxamide. Christen M. Giandomenico, Chiu T. Lam, and Stephen J. Lippard, J. Am. Chem. Soc., 104, 1263-1271 (1982).
Lyophilization Results in Cleavage of the Active-Site Histidine Bridge in the Four-Copper Form of Bovine Erythrocyte Superoxide Dismutase. Kenneth G. Strothkamp and Stephen J. Lippard, J. Am. Chem. Soc., 104, 852-853 (1982).
Magnetic Exchange in Imidazolate-Bridged Copper(II) Complexes. Gary Kolks, Stephen J. Lippard, Joseph V. Waszczak, and Henry R. Lilienthal, J. Am. Chem. Soc., 104, 717-725 (1982).
Improved Synthesis of Seven-Coordinate Molybdenum(II) and Tungsten(II) Isocyanide Complexes. Dealkylation of Coordinated tert-Butyl Isocyanide. Christen M. Giandomenico, Lawrence H. Hanau, and Stephen J. Lippard, Organometallics, 1, 142-148 (1982).
Crystal Structure of the Homoleptic Seven-Coordinate Complex Heptakis(tert-butyl isocyanide)chromium(II) Hexafluorophosphate, [Cr(CN-t-Bu)7](PF6)2. John C. Dewan, William S . Mialki, Richard A. Walton, and Stephen J. Lippard, J. Am. Chem. Soc., 104, 133-136 (1982).
1981
Anion Binding to the Four-Copper Form of Bovine Erythrocyte Superoxide Dismutase: Mechanistic Implications. Kenneth G. Strothkamp and Stephen J. Lippard, Biochemistry, 20, 7488-7493 (1981).
Dealkylation and Reductive Coupling of tert-Butyl Isocyanide Ligands in Heptakis(tert-butyl) isocyanide)molybdenum(II). Structure of Seven-Coordinate Cyanotetrakis(tert-butyl isocyanide)((N,N'-di-tert-butyldiamino)acetylene)molybdenum(II) Tetraphenylborate. John C. Dewan, Christen M. Giandomenico, and Stephen J. Lippard, Inorg. Chem., 20, 4069-4074 (1981).
Structural Studies of Three Seven-Coordinate Isocyanide Complexes of Molybdenum(II) and Tungsten(II). David J. Szalda, John C. Dewan, and Stephen J. Lippard, Inorg. Chem., 20, 3851-3857 (1981).
Synthesis, Structure, and Electrochemical Behavior of cis-Diammineplatinum(III) Dimers with Bridging α-Pyridonate Ligands. L. Steven Hollis and Stephen J. Lippard, J. Am. Chem. Soc., 103, 6761-6763 (1981).
Binding of the Antitumor Drug cis-Diamminedichloroplatinum(II) to DNA and to the Nucleosome Core Particle. Stephen J. Lippard, In: Biomolecular Stereodynamics, Volume II, Ramaswamy H. Sarma, Ed., Adenine Press: New York, 165-183 (1981).
Synthesis and Structure of Hexakis(tert-butyl isocyanide)vanadium(II) Hexacarbonylvanadate(-I). Lance D. Silverman, Peter W. R. Corfield, and Stephen J. Lippard, Inorg. Chem., 20, 3106-3109 (1981).
Synthetic, Spectroscopic, and Solution Studies of Imidazolate-Bridged Dicopper(II) Complexes. Gary Kolks, Charles R. Frihart, Peter K. Coughlin, and Stephen J. Lippard, Inorg. Chem., 20, 2933-2940 (1981).
Synthesis, Structure, and Properties of an Imidazolate-Bridged Copper(II)-Cobalt(III) Complex. William M. Davis, John C. Dewan, and Stephen J. Lippard, Inorg. Chem., 20, 2928-2932 (1981).
Crystal and Molecular Structure of Triiodo(η5-Methylcyclopentadienyl)dicarbonylmolybdenum(IV), (η5-CH3C5H4)Mo(CO)2I3. Brian S. Erler, John C. Dewan, Stephen J. Lippard, and David R. Tyler, Inorg. Chem., 20, 2719-2722 (1981).
cis-Diamminedichloroplatinum(II) Binds in a Unique Manner to Oligo(dG)·Oligo(dC) Sequences in DNA – A New Assay Using Exonuclease III. Thomas D. Tullius and Stephen J. Lippard, J. Am. Chem. Soc., 103, 4620-4622 (1981).
Inhibition of the BamHI Cleavage and Unwinding of pBR322 Deoxyribonucleic Acid by the Antitumor Drug cis-Dichlorodiammineplatinum(II). H. Michael Ushay, Thomas D. Tullius, and Stephen J. Lippard, Biochemistry, 20, 3744-3748 (1981).
A Monohydroxo Bridged, Strongly Antiferromagnetically Coupled Dicopper(II) Center in a Binucleating Macrocycle. Comparisons with Binuclear Copper Sites in Biology. Peter K. Coughlin and Stephen J. Lippard, J. Am. Chem. Soc., 103, 3228-3229 (1981).
Synthesis, Structure, and Reactions of [Mo(SnCl3)(CN-t-Bu)6][(Ph3B)2CN], Containing a Potentially Useful New Anion for Crystallizations. Christen M. Giandomenico, John C. Dewan, and Stephen J. Lippard, J. Am. Chem. Soc., 103, 1407-1412 (1981).
New Reaction Chemistry of cis-Diammineplatinum(II) with α-Pyridone. Crystalline Relatives of the α-Pyridone Blue. L. Steven Hollis and Stephen J. Lippard, J. Am. Chem. Soc., 103, 1230-1232 (1981).
Structure Determinations of Halotetrakis(tert-butyl isocyanide)((N,N'-di-tert-butyldiamino)acetylene)molybdenum(II) Complexes. Peter W. R. Corfield, Laima M. Baltusis, and Stephen J. Lippard, Inorg. Chem., 20, 922-929 (1981).
1980
Binding of a Platinum Antitumor Drug to its Likely Biological Targets. Stephen J. Lippard, In: Inorganic Chemistry in Biology and Medicine, Arthur E. Martell, Ed., ACS Symp. Ser., 140, 147-156 (1980).
Enhanced Stability of the Imidazolate-Bridged Dicopper(II) Ion in a Binucleating Macrocycle. Peter K. Coughlin, Stephen J. Lippard, Andrea E. Martin, and John E. Bulkowski, J. Am. Chem. Soc., 102, 7616-7617 (1980).
An Asymmetric Imidazolate-Bridged Dicopper(II) Complex. Robert N. Katz, Gary Kolks, and Stephen J. Lippard, Inorg. Chem., 19, 3845-3847 (1980).
Polymetallic Centers in Biology. Stephen J. Lippard, In: Mixed Valence Compounds, Theory and Applications in Chemistry, Physics, Geology and Biology, David B. Brown, Ed., D. Reidel: Dordrecht, Holland, 427-450 (1980).
Molecular Structure and Ligand-Exchange Reactions of Trichlorotris(tert-butyl isocyanide)vanadium(III). Synthesis of the Hexakis(tert-butyl isocyanide)vanadium(II) Cation. Lance D. Silverman, John C. Dewan, Christen M. Giandomenico, and Stephen J. Lippard, Inorg. Chem., 19, 3379-3383 (1980).
Aqueous Platinum(II) Chemistry; Binding to Biological Molecules. Mary Howe-Grant and Stephen J. Lippard, In: Metal Ions in Biological Systems: Metal Complexes as Anticancer Agents, Helmut Sigel, Ed., Marcel Dekker: New York, 11, 63-125 (1980).
Nuclear Magnetic Resonance Study of the Exchangeable Histidine Protons in Bovine and Wheat Germ Superoxide Dismutases. Allan R. Burger, Stephen J. Lippard, Michael W. Pantoliano, and Joan S. Valentine, Biochemistry, 19, 4139-4143 (1980).
Synthesis and Structure of Fe(L'H)(NO)2, a Tetracoordinate Complex Having a Twelve-Membered Chelate Ring, and Its Conversion to Pentacoordinate FeL'(NO) through Formal Loss of "HNO" (L' = -SCH2CH2NMeCH2CH2CH2NMeCH2CH2S-). Laima M. Baltusis, Kenneth D. Karlin, Harold N. Rabinowitz, John C. Dewan, and Stephen J. Lippard, Inorg. Chem., 19, 2627-2632 (1980).
Metallointercalation Reagents: Thiolato Complexes of (2, 2' :6', 2"-Terpyridine)Platinum(II). Mary Howe-Grant and Stephen J. Lippard, Inorg. Synth., 20, 101-105 (1980).
Reactions of Superoxide Anion with Copper(II) Salicylate Complexes. Chi-Lin O'Young and Stephen J. Lippard, J. Am. Chem. Soc., 102, 4920-4924 (1980).
A Tricopper(II) Complex Containing a Triply Bridging Carbonate Group. Gary Kolks, Stephen J. Lippard, and Joseph V. Waszczak, J. Am. Chem. Soc., 102, 4832-4833 (1980).
Structure of the Imidazolate-Bridged Dicopper(II) Cation Cu2(bpim)3+. John C. Dewan and Stephen J. Lippard, Inorg. Chem., 19, 2079-2082 (1980).
Synthesis and Physical Properties of Hexakis(isothiocyanato)technetate(III) and -(IV) Complexes. Structure of the [Tc(NCS)6]3- Ion. Harvey S. Trop, Alan Davison, Alun G. Jones, Michael A. Davis, David J. Szalda, and Stephen J. Lippard, Inorg. Chem., 19, 1105-1110 (1980).
Sequence Dependent Binding of cis-Dichlorodiammineplatinum(II) to DNA. Gary L. Cohen, Jay A. Ledner, William R. Bauer, H. Michael Ushay, Carl Caravana, and Stephen J. Lippard, J. Am. Chem. Soc., 102, 2487-2488 (1980).
Heavy Metal Interactions with Nucleic Acids. Jacqueline K. Barton and Stephen J. Lippard, In: Nucleic Acid-Metal Ion Interactions, Thomas G. Spiro, Ed., Met. Ions Biol., 1, 31-113 (1980).
Synthesis and Structure of a Bis[terpyridineplatinum(II)] Complex and Its Evaluation as a Metallointercalator. John C. Dewan, Stephen J. Lippard, and William R. Bauer, J. Am. Chem. Soc., 102, 858-860 (1980).
1979
Binding of Platinum(II) Intercalation Reagents to Deoxyribonucleic Acid. Dependence on Base-Pair Composition, Nature of the Intercalator, and Ionic Strength. Mary Howe-Grant and Stephen J. Lippard, Biochemistry, 18, 5762-5769 (1979). Ibid, 19, 4385 (1980).
Binding of cis- and trans-dichlorodiammineplatinum(II) to the nucleosome core. Stephen J. Lippard and James D. Hoeschele, Proc. Natl. Acad. Sci. U. S. A., 76, 6091-6095 (1979).
Visualization of Polymercurimethane-Labeled fd Bacteriophage in the Scanning Transmission Electron Microscope. James J. Lipka, Stephen J. Lippard, and Joseph S. Wall, Science, 206, 1419-1421 (1979).
Chemical and Spectroscopic Characterization of cis-Diammineplatinum α-Pyridone Blue in Aqueous Solution. Comparison with Other Platinum Blues. Jacqueline K. Barton, Carl Caravana, and Stephen J. Lippard, J. Am. Chem. Soc., 101, 7269-7277 (1979).
Specific Heavy Metal Labeling of the 3'-Terminus of Phosphorothioate Modified Yeast tRNAPhe. David J. Szalda, Frtiz Eckstein, Hans Sternbach, and Stephen J. Lippard, J. Inorg. Biochem., 11, 279-282 (1979).
pH-dependent migration of copper(II) to the vacant zinc-binding site of zinc-free bovine erythrocyte superoxide dismutase. Joan S. Valentine, Michael W. Pantoliano, Peter J. McDonnell, Allan R. Burger, and Stephen J. Lippard, Proc. Natl. Acad. Sci. U. S. A., 76, 4245-4249 (1979).
Synthesis and Structure of Diiododicarbonyltris(tert-butyl isocyanide)tungsten(II), an Example of the 4:3 Piano Stool Seven-Coordinate Geometry. Evan B. Dreyer, Chiu T. Lam, and Stephen J. Lippard, Inorg. Chem., 18, 1904-1908 (1979).
Cooperative Binding of a Platinum Metallointercalation Reagent to Poly(A)·Poly(U). Jacqueline K. Barton and Stephen J. Lippard, Biochemistry, 18, 2661-2668 (1979).
Solid State Structure, Magnetic Susceptibility, and Single Crystal ESR Properties of cis-Diammineplatinum α-Pyridone Blue. Jacqueline K. Barton, David J. Szalda, Harold N. Rabinowitz, Joseph V. Waszczak, and Stephen J. Lippard, J. Am. Chem. Soc., 101, 1434-1441 (1979).
Binding of cis- and trans-Dichlorodiammineplatinum(II) to DNA: Evidence for Unwinding and Shortening of the Double Helix. Gary L. Cohen, William R. Bauer, Jacqueline K. Barton, and Stephen J. Lippard, Science, 203, 1014-1016 (1979).
Synthesis and Structure of the Imidazolate Bridged Dicopper(II) Ion Incorporated Into a Circular Cryptate Macrocycle. Peter K. Coughlin, John C. Dewan, Stephen J. Lippard, Eiichi Watanabe, and Jean-Marie Lehn, J. Am. Chem. Soc., 101, 265-266 (1979).
1978
Electron Spin Resonance, Magnetic, and X-ray Crystallographic Studies of a Binuclear, Imidazolate Bridged Copper(II) Complex, [(TMDT)2Cu2(im)(ClO4)2](ClO4). Chi-Lin O'Young, John C. Dewan, Henry R. Lilienthal, and Stephen J. Lippard, J. Am. Chem. Soc., 100, 7291-7300 (1978).
A Crystalline Platinum Blue: Its Molecular Structure, Chemical Reactivity, and Possible Relevance to the Mode of Action of Antitumor Platinum Drugs. Jacqueline K. Barton and Stephen J. Lippard, Ann. N. Y. Acad. Sci., 313, 686-700 (1978).
Synthesis and Characterization of Seven-Coordinate Molybdenum(II) and Tungsten(II) Isocyanide Complexes. Chiu T. Lam, Miroslav Novotny, David L. Lewis, and Stephen J. Lippard, Inorg. Chem., 17, 2127-2133 (1978).
Relationship of cis-Diammineplatinum α-Pyridone Blue to Other Platinum Blues. An X-Ray Photoelectron Study. Jacqueline K. Barton, Stephen A. Best, Stephen J. Lippard, and Richard A. Walton, J. Am. Chem. Soc., 100, 3785-3788 (1978).
Platinum Complexes: Probes of Polynucleotide Structure and Antitumor Drugs. Stephen J. Lippard, Acc. Chem. Res., 11, 211-217 (1978).
Study of the Binding of cis- and trans-Dichlorodiammineplatinum(II) to Calf Thymus DNA by Extended X-Ray Absorption Fine Structure Spectroscopy. Boon-Keng Teo, Peter Eisenberger, Joseph Reed, Jacqueline K. Barton, and Stephen J. Lippard, J. Am. Chem. Soc., 100, 3225-3227 (1978).
Transition Metal Hydroborate Complexes. 10. Crystal and Molecular Structure of Tris(tetrahydroborato)tris(tetrahydrofuran)yttrium(III). Bernice G. Segal and Stephen J. Lippard, Inorg. Chem., 17, 844-850 (1978).
Tetrakis(acetoxymercuri)methane: A polymetallic reagent for labeling sulfur in nucleic acids. Kenneth G. Strothkamp, J. Lehmann, and Stephen J. Lippard, Proc. Natl. Acad. Sci. U. S. A., 75, 1181-1184 (1978).
Binding of the Antitumor Drug Platinum Uracil Blue to Closed and Nicked Circular Duplex DNAs. William R. Bauer, Steven L. Gonias, Siu K. Kam, Kun C. Wu, and Stephen J. Lippard, Biochemistry, 17, 1060-1068 (1978).
1977
X-Ray Crystal Structure of a 2:2 Chloroterpyridineplatinum(II)-Adenosine-5'-monophosphate Intercalation Complex. Yau-Shing Wong and Stephen J. Lippard, J. Chem. Soc., Chem. Commun., 824-825 (1977).
Synthesis and Characterization of the Pentacoordinate Mononitrosyliron Complexes Fe(NO)[SCH2CH2N(CH3)(CH2)nN(CH3)CH2CH2S], n = 2, 3. Kenneth D. Karlin, Harold N. Rabinowitz, David L. Lewis, and Stephen J. Lippard, Inorg. Chem., 16, 3262-3267 (1977).
Magnetic Exchange Interactions in Imidazolate Bridged Copper(II) Complexes. Gary Kolks and Stephen J. Lippard, J. Am. Chem. Soc., 99, 5804-5806 (1977).
Physical and Chemical Studies of Bovine Erythrocyte Superoxide Dismutase. Stephen J. Lippard, Allan R. Burger, Kamil Ugurbil, Joan S. Valentine, and Michael W. Pantoliano, Adv. Chem. Ser., 162, 251-262 (1977).
Transition Metal Hydroborate Complexes. 9. Preparation, Properties, and Structure of Di-μ-cyanotrihydroborato-bis(2,2',2"-triaminotriethylamine)dinickel(II) Tetraphenylborate. Bernice G. Segal and Stephen J. Lippard, Inorg. Chem., 16, 1623-1629 (1977).
Hydrolysis Reactions of 2,4,6-Tris(2-pyrimidyl)- and 2,4,6-Tris(2-pyridyl)-1,3,5-triazines with Divalent Copper. Structure of a Bis(2-pyrimidylcarbonyl)aminatocopper(II) Complex. Elliot I. Lerner and Stephen J. Lippard, Inorg. Chem., 16, 1546-1551 (1977).
Heavy-Metal Complexes of 2,4,6-Tris(2-pyrimidyl)-1,3,5-triazine. Structure of a Dilead Derivative. Elliot I. Lerner and Stephen J. Lippard, Inorg. Chem., 16, 1537-1546 (1977).
Synthesis and Crystal Structure of cis-Diammineplatinum α-Pyridone Blue. Jacqueline K. Barton, Harold N. Rabinowitz, David J. Szalda, and Stephen J. Lippard, J. Am. Chem. Soc., 99, 2827-2829 (1977).
Nuclear Magnetic Resonance and Chemical Modification Studies of Bovine Erythrocyte Superoxide Dismutase: Evidence for Zinc-Promoted Organization of the Active Site Structure. Stephen J. Lippard, Allan R. Burger, Kamil Ugurbil, Michael W. Pantoliano, and Joan S. Valentine, Biochemistry, 16, 1136-1141 (1977).
Oxidative Addition of Nitrosonium Ion to Sulfur-Bridged Binuclear Iron(II) and Cobalt(II) Complexes. Harold N. Rabinowitz, Kenneth D. Karlin, and Stephen J. Lippard, J. Am. Chem. Soc., 99, 1420-1426 (1977).
Reductive Coupling of Adjacent Ligands in a Seven-Coordinate Molybdenum(II) Isocyanide Complex. Chiu T. Lam, Peter W. R. Corfield, and Stephen J. Lippard, J. Am. Chem. Soc., 99, 617-618 (1977).
1976
Stereochemical Requirements for Intercalation of Platinum Complexes into Double-Stranded DNAs. Stephen J. Lippard, Peter J. Bond, Kun C. Wu, and William R. Bauer, Science, 194, 726-728 (1976).
Orbitally Dependent Exchange in Two Sulfur-Bridged Binuclear Iron(II) Complexes. Magnetic Exchange in Transition Metal Complexes. 11. Alvin P. Ginsberg, Malcolm E. Lines, Kenneth D. Karlin, Stephen J. Lippard, and Francis J. DiSalvo, J. Am. Chem. Soc., 98, 6958-6966 (1976).
Sulfur-Bridged Binuclear Iron(II) Complexes. Effect of Ligand Constraints on Their Physical Properties; Reactions with Carbon Monoxide and Alkyl Isocyanides. Kenneth D. Karlin and Stephen J. Lippard, J. Am. Chem. Soc., 98, 6951-6957 (1976).
Metallointercalation Reagents. Synthesis, Characterization, and Structural Properties of Thiolato(2,2',2"-terpyridine)platinum(II) Complexes. Karen W. Jennette, John T. Gill, Janet A. Sadownick, and Stephen J. Lippard, J. Am. Chem. Soc., 98, 6159-6168 (1976).
Binding of Platinum and Palladium Metallointercalation Reagents and Antitumor Drugs to Closed and Open DNAs. Mary Howe-Grant, Kun C. Wu, William R. Bauer, and Stephen J. Lippard, Biochemistry, 15, 4339-4346 (1976).
Imidazolate-Bridged Complexes of Copper(II). Gary Kolks, Charles R. Frihart, Harold N. Rabinowitz, and Stephen J. Lippard, J. Am. Chem. Soc., 98, 5720-5721 (1976).
Platinum binds selectively to phosphorothioate groups in mono- and polynucleotides: A general method for heavy metal staining of specific nucleotides. Kenneth G. Strothkamp and Stephen J. Lippard, Proc. Natl. Acad. Sci. U.S.A., 73, 2536-2540 (1976).
2,4,6-Tris(2-pyrimidyl)- and 2,4,6-Tris(2-pyridyl)-1,3,5-triazines Hydrolyze in the Presence of Copper(II) to Form a Novel Bis(aryl)carboximidato Chelate Complex. Elliot I. Lerner and Stephen J. Lippard, J. Am. Chem. Soc., 98, 5397-5398 (1976).
Structural Determinations of Four Mono- and Binuclear Tertiary Phosphine and Arsine Complexes of Copper(I) Chloride. John T. Gill, James J. Mayerle, Peter S. Welcker, David F. Lewis, David A. Ucko, D. J. Barton, D. Stowens, and Stephen J. Lippard, Inorg. Chem., 15, 1155-1168 (1976).
Crystal and Molecular Structure of trans-Oxochlorotetrakis(methyl isocyanide)molybdenum(IV) Triiodide. Chiu T. Lam, David L. Lewis, and Stephen J. Lippard, Inorg. Chem., 15, 989-991 (1976).
Seven and Eight Coordinate Molybdenum Complexes, and Related Molybdenum(IV) Oxo Complexes, with Cyanide and Isocyanide Ligands. Stephen J. Lippard, Prog. Inorg. Chem., 21, 91-103 (1976).
1975
X-ray fiber diffraction evidence for neighbor exclusion binding of a platinum metallointercalation reagent to DNA. Peter J. Bond, Robert Langridge, Karen W. Jennette, and Stephen J. Lippard, Proc. Natl. Acad. Sci. U.S.A., 72, 4825-4829 (1975).
Reaction of Diethylamine with Mercaptide-Bridged Binuclear Cobalt(III) and Iron(III) Thioxanthate Complexes. Crystal Structure of Co2(SC2H5)2(S2CSC2H5)[S2CN(C2H5)2]3. Robert A. Winograd, David L. Lewis, and Stephen J. Lippard, Inorg. Chem., 14, 2601-2609 (1975).
13C Magnetic Resonance Investigation of Mercury(II) Binding to Nucleosides and Thiolated Nucleosides in Dimethyl Sulfoxide. Karen W. Jennette, Stephen J. Lippard, and David A. Ucko, Biochim. Biophys. Acta, 402, 403-412 (1975).
The Structure of Heptakis(tert-butyl isocyanide)molybdenum(II) Hexafluorophosphate, a Seven-Coordinate Complex with C2v Monocapped Trigonal Prismatic Geometry. David L. Lewis and Stephen J. Lippard, J. Am. Chem. Soc., 97, 2697-2702 (1975).
Transition Metal Hydroborate Complexes. VIII. Structure of {[(C6H5)3P]2Cu}2B10H10·CHCl3. Bonding Analogies between Boron Hydrides and nido-Metalloboranes. John T. Gill and Stephen J. Lippard, Inorg. Chem., 14, 751-761 (1975).
Raman and Infrared Spectra of Hf(BH4)4 and Hf(BD4)4. Evidence for Hf-B Bonding. Timothy A. Keiderling, W. T. Wozniak, R. S. Gay, Donald Jurkowitz, Elliot R. Bernstein, Stephen J. Lippard, and Thomas G. Spiro, Inorg. Chem., 14, 576-579 (1975).
1974
Metallointercalation Reagents. 2-Hydroxyethanethiolato(2,2',2"-terpyridine)-platinum(II) Monocation Binds Strongly to DNA by Intercalation. Karen W. Jennette, Stephen J. Lippard, G. A. Vassiliades, and William R. Bauer, Proc. Natl. Acad. Sci. U.S.A., 71, 3839-3843 (1974).
Addition of Nitrosonium Ion to Mercaptide-Bridged Binuclear Iron(II) and Cobalt(II) Complexes. Kenneth D. Karlin, David L. Lewis, Harold N. Rabinowitz, and Stephen J. Lippard, J. Am. Chem. Soc., 96, 6519-6521 (1974).
Crystal and Molecular Structure of Tris(ethyl thioxanthato)cobalt(III). A Reinvestigation. Ting-i Li and Stephen J. Lippard, Inorg. Chem., 13, 1791-1792 (1974).
Mercury(II) Binding to s4U in E. coli tRNAVal. Helen R. Sunshine and Stephen J. Lippard, Nucleic Acids Res., 1, 673-688 (1974).
Effect of Ligand Constraints on the Geometry of Two Sulfur-Bridged Binuclear Iron(II) Complexes. The Structures of Bis{μ-[N,N'-dimethyl-N,N'-bis(β-mercaptoethyl)ethylenediamine]}-diiron(II) and Bis{μ-[N,N'-dimethyl-N,N'-bis(β-mercaptoethyl)-1,3-propanediamine]}diiron(II). Wei-jen Hu and Stephen J. Lippard, J. Am. Chem. Soc., 96, 2366-2372 (1974).
Synthesis and Properties of Cationic Molybdenum(IV) Oxohaloisocyanide Complexes. Miroslav Novotny and Stephen J. Lippard, Inorg. Chem., 13, 828-831 (1974).
Transition Metal Hydroborate Complexes. VII. Preparation, Properties, and Structure of Bis(cyanotrihydroborato)-1,1,4,7,7-pentamethyldiethylenetriaminecopper(II). Bernice G. Segal and Stephen J. Lippard, Inorg. Chem., 13, 822-828 (1974).
Synthesis and Molecular Structure of Bis(6-mercapto-9-benzylpurine)palladium(II)-Dimethylacetamide. Howard I. Heitner and Stephen J. Lippard, Inorg. Chem., 13, 815-822 (1974).
Mössbauer Spectroscopy Studies of Beef-Heart Cytochrome c Oxidase. George Lang, Stephen J. Lippard, and Steffen Rosén, Biochim. Biophys. Acta, 336, 6-14 (1974).
Transition Metal Hydroborate Complexes. VI. The Solid-State Structure of μ-Bis(cyanotrihydroborato)tetrakis(triphenylphosphine)dicopper(I). Kenneth M. Melmed, Ting-i Li, James J. Mayerle, and Stephen J. Lippard, J. Am. Chem. Soc., 96, 69-75 (1974). Ibid, 97, 1987-1988 (1975)
1973
Synthesis and Stereochemistry of π-Allylmonothio-β-diketonatopalladium(II)-Olefin Insertion Products. Janet A. Sadownick and Stephen J. Lippard, Inorg. Chem., 12, 2659-2665 (1973).
Iron-Sulfur Coordination Compounds and Proteins. Stephen J. Lippard, Acct. Chem. Res., 6, 282-288 (1973).
Heptakis(alkyl isocyanide)molybdenum(II) Complexes. Miroslav Novotny and Stephen J. Lippard, J. Chem. Soc., Chem. Commun., 202 (1973).
Transition Metal Hydroborate Complexes. V. Crystal Structure of Tetrahydroboratobis(cyclopentadienyl)titanium(III). Kenneth M. Melmed, Dmitri Coucouvanis, and Stephen J. Lippard, Inorg. Chem., 12, 232-236 (1973).54.
1972
Metal Binding by Thionucleosides. Howard I. Heitner, Stephen J. Lippard, and Helen R. Sunshine, J. Am. Chem. Soc., 94, 8936-8937 (1972).
14-Coordinate Uranium(IV). The Structure of Uranium Borohydride by Single-Crystal Neutron Diffraction. Elliot R. Bernstein, Walter C. Hamilton, Timothy A. Keiderling, Sam J. La Placa, Stephen J. Lippard, and James J. Mayerle, Inorg. Chem., 11, 3009-3016 (1972).
Reactions of Eight-Coordinate Metal Cyanide Complexes. IV. Synthesis and Spectroscopic and Structural Properties of Tetracyanotetrakis(alkyl isocyanide)molybdenum(IV) Complexes. Miroslav Novotny, David F. Lewis, and Stephen J. Lippard, J. Am. Chem. Soc., 94, 6961-6968 (1972).
Crystal and Molecular Structure of Monothiodibenzoylmethanato-π-syn-1-tert-butyl-2-methallylpalladium(II). Stephen J. Lippard and Sheila M. Morehouse, J. Am. Chem. Soc., 94, 6956-6960 (1972).
Synthesis and Solution Behavior of Some π-Allyl Monothiodibenzoylmethanatopalladium(II) Complexes. Stephen J. Lippard and Sheila M. Morehouse, J. Am. Chem.Soc., 94, 6949-6956 (1972).
Synthesis and Fluxional Properties of Monothio-β-diketonatorhodium(I) Diolefin Complexes. Howard I. Heitner and Stephen J. Lippard, Inorg. Chem., 11, 1447-1453 (1972).
The Crystal and Molecular Structure of Tris(tert-butyl thioxanthato)iron(III). David F. Lewis, Stephen J. Lippard, and Jon A. Zubieta, Inorg. Chem., 11, 823-828 (1972).
The Behavior of Tertiary Phosphine and Arsine Complexes of Copper(I) in Chloroform Solution. Stephen J. Lippard and James J. Mayerle, Inorg. Chem., 11, 753-759 (1972).
Structure of Uranium Borohydride by Single-Crystal X-Ray Diffraction. Elliot R. Bernstein, Timothy A. Keiderling, Stephen J. Lippard, and James J. Mayerle, J. Am. Chem. Soc., 94, 2552-2553 (1972).
Synthesis and Study of Monomeric and Sulfur-Bridged Dimeric Cobalt(III) Thioxanthate Complexes and Their Relationship to Sulfur-Bridged Iron(III) Dimers. David F. Lewis, Stephen J. Lippard, and Jon A. Zubieta, J. Am. Chem. Soc., 94, 1563-1575 (1972).
Reactions of Eight-Coordinate Metal Cyanide Complexes. III. Synthesis and Structure of Iodohexakis(tert-butyl isocyanide)molybdenum(II) Iodide. David F. Lewis and Stephen J. Lippard, Inorg. Chem., 11, 621-626 (1972).
Transition Metal Hydroborate Complexes. IV. Cyanotrihydroborate Complexes of the Group Ib Metals. Stephen J. Lippard and Peter S. Welcker, Inorg. Chem., 11, 6-11 (1972).
1971
Factors Influencing the Stereochemistry of Four-Coordinate Copper(I)-Phosphine Complexes. Stephen J. Lippard and Gus J. Palenik, Inorg. Chem., 10, 1322-1324 (1971).
1970
Crystal and Molecular Structure of [1.1.1]Ferrocenophane. Stephen J. Lippard and Geoffrey Martin, J. Am. Chem. Soc., 92, 7291-7296 (1970).
The Crystal and Molecular Structure of Bis(ethyl thioxanthato)-μ-bis(ethyl thioxanthato)-μ'-bis(ethylthio)-diiron(III). Dmitri Coucouvanis, Stephen J. Lippard, and Jon A. Zubieta, Inorg. Chem., 9, 2775-2781 (1970).
Structure of Dichlorotris(triphenylphosphine)dicopper(I)-Benzene, a Chloride-Bridged Dimer Containing both Three- and Four-Coordinate Copper. David F. Lewis, Stephen J. Lippard, and Peter S. Welcker, J. Am. Chem. Soc., 92, 3805-3807 (1970).
Intramolecular Rearrangements in Asymmetric Rhodium(I) Diolefin Complexes. Howard I. Heitner and Stephen J. Lippard, J. Am. Chem. Soc., 92, 3486-3488 (1970).
Sulfur-Bridged Dimeric Complexes of Iron(III). Dmitri Coucouvanis, Stephen J. Lippard, and Jon A. Zubieta, J. Am. Chem. Soc., 92, 3342-3347 (1970).
Transition-metal Cyanotrihydroborate Complexes. Stephen J. Lippard and Peter S. Welcker, J. Chem. Soc. D, 515 (1970).
Reactions of Eight-Coordinate Metal Cyanide Complexes. II. Interaction of Octacyanomolybdate(IV) with Uranyl Salts. Mark Allen and Stephen J. Lippard, Inorg. Chem., 9, 991-993 (1970).
1969
Transition Metal Borohydride Complexes. III. The Structure of Octahydrotriboratobis(triphenylphosphine)copper(I). Stephen J. Lippard and Kenneth M. Melmed, Inorg. Chem., 8, 2755-2762 (1969).
The Solid-State Structure of Monothiodibenzoylmethanato-π-methallylpalladium(II). Stephen J. Lippard and Sheila M. Morehouse, J. Am. Chem. Soc., 91, 2504-2509 (1969).
A Dimeric Iron(III) Complex Containing Two Ethyl Mercaptide and Two Ethyl Thioxanthate Groups as Bridging Ligands. Dimitri Coucouvanis, Stephen J. Lippard, and Jon A. Zubieta, J. Am. Chem. Soc., 91, 761-762 (1969).
Metal Pi-Organic Complexes: Nature of Bonding and their Role in Chemistry. Stephen J. Lippard, Ann. N. Y. Acad. Sci., 153, 677-688 (1969).
The Crystal and Molecular Structure of Thio-p-toluoyldisulfidobis(dithio-p-toluato)iron(III). Dimitri Coucouvanis and Stephen J. Lippard, J. Am. Chem. Soc., 91, 307-311 (1969).
1968
Comment on the Choice of an Eight-Coordinate Polyhedron. Stephen J. Lippard and Brian J. Russ, Inorg. Chem., 7, 1686-1688 (1968).
Preparation and Structural Characterization of Six-Coordinate Iron(III) Complexes Containing the Fe-S-S Linkage. Dimitri Coucouvanis and Stephen J. Lippard, J. Am. Chem. Soc., 90, 3281-3282 (1968).
Transition Metal Borohydride Complexes. II. The Reaction of Copper(I) Compounds with Boron Hydride Anions. Stephen J. Lippard and David A. Ucko, Inorg. Chem., 7, 1051-1056 (1968).
1967
Studies of Iron Tricarbonyl Cyclooctatetraene Complexes. Robert H. Grubbs, Ronald Breslow, Rolfe Herber, and Stephen J. Lippard, J. Am. Chem. Soc., 89, 6864-6870 (1967).
Stereochemically Dynamic Organometallic Compounds. Stephen J. Lippard, Trans. N. Y. Acad. Sci., 29, 917-919 (1967).
Transition Metal Borohydride Complexes. I. The Solid State Structure of Borohydridobis(triphenylphosphine)copper(I). Stephen J. Lippard and Kenneth M. Melmed, Inorg. Chem., 6, 2223-2228 (1967).
Eight-Coordination Chemistry. Stephen J. Lippard, Prog. Inorg. Chem., 8, 109-193 (1967).
Reactions of Eight-Coordinate Metal Cyanide Complexes. I. Molybdenum(IV) and Tungsten (IV) Oxocyanide Complexes. Stephen J. Lippard and Brian J. Russ, Inorg. Chem., 6, 1943-1947 (1967).
Preparation and Characterization of Octahydrotriboratobis(triphenylphosphine)copper(I). Stephen J. Lippard and David A. Ucko, Chem. Commun. (London), 983 (1967).
The Crystal and Molecular Structure of an Oxo-bridged Binuclear Iron(III) Complex, [(HEDTA)FeOFe(HEDTA)]2-. Stephen J. Lippard, Harvey Schugar, and Cheves Walling, Inorg. Chem., 6, 1825-1831 (1967).
Transition Metal Borohydride Complexes. I. The Structure of Borohydridobis(triphenylphosphine)copper(I). Stephen J. Lippard and Kenneth M. Melmed, J. Am. Chem. Soc., 89, 3929-3930 (1967).
Molybdenum(IV) and Tungsten(IV) Oxocyanide Complexes. Stephen J. Lippard, H. Nozaki, and Brian J. Russ, Chem. Commun. (London), 118-119 (1967).
1966
A Volatile Inorganic Salt, Cs[Y(CF3COCHCOCF3)4]. Stephen J. Lippard, J. Am. Chem. Soc., 88, 4300-4301 (1966).
Geometric Isomerism in Eight-Coordinate Complexes, Especially Rare Earth β-Diketonates. Stephen J. Lippard, In: Proceedings of the IX International Conference on Coordination Chemistry, Walter Schneider, Ed., Verlag Helvetica Chimica Acta: Basle, Switzerland, 476 (1966).