Lippard Lab

Patents

Active patents:

  1. Novel Coordination Complexes, and Methods for Preparing by Combinatorial Methods, Assaying and Using Same. Stephen J. Lippard and Christopher J. Ziegler. Patent #6,806,289. October 19, 2004. MIT #8541
  2. Fluorescent Metal Sensors, and Methods of Making and Using the Same. Shawn Burdette and Stephen J. Lippard. Patent #7,018,840. March 28, 2006. MIT #10027
  3. Fluorescein-Based Metal Sensors and Methods of Making and Using the Same. Shawn C. Burdette, Stephen J. Lippard, and Elizabeth M. Nolan. Patent #7,160,732. January 9, 2007. MIT #8910
  4. Sensors, And Methods Of Making And Using The Same. Stephen J. Lippard and Carolyn C. Woodroofe. Patent #7,399,639. July 15, 2008. MIT #10294
  5. Naphthoflurescein-Based Metal Sensors, And Methods Of Making And Using The Same. Christopher J. Chang, Stephen J. Lippard and Elizabeth M. Nolan. Patent #7,488,820. February 10, 2009. MIT #10450
  6. Fluorescein Based Sensors For Tracking Nitric Oxide In Live Cells. Mi Hee Lim and Stephen J. Lippard. Patent #7,494,821. February 24, 2009. MIT #11806
  7. Fluorescein-Based Metal Sensors. Elizabeth M. Nolan and Stephen J. Lippard. Patent #7,615,377. November 10, 2009. MIT #10395
  8. Coordination Complexes, and Methods for Preparing by Combinatorial Methods, Assaying and Using the Same. Christopher J. Ziegler and Stephen J. Lippard. Patent #7,651,979 B2. January 26, 2010. MIT #8541
  9. Sensors for Fluorescence and Magnetic Imaging Resonance Imaging. Xiao-An Zhang, Alan Pradip Jasanoff, and Stephen J. Lippard. Patent #8,133,474 B2. March 13, 2012. MIT #12381
  10. Methods for Mobile Zinc Measurement. Stephen J. Lippard, Xiao-an Zhang, Zdravka Medarova, and Anna Moore. Patent #8,574,914. November 5, 2013. MIT #13859
  11. Nanostructures for Drug Delivery. Stephen J. Lippard, Shanta Dhar, Omid C. Farokhzad, Frank X. Gu, and Nagesh Kolishetti. Patent #8,603,532. December 10, 2013. MIT #13405
  12. Inhibitors of Bacterial Nitric Oxide Synthase, and Related Screening Methods. Lindsey E. McQuade and Stephen J. Lippard. Patent #8,709,743 B2. April 29, 2014. MIT #12903J
  13. Platinum Compounds as Treatment for Cancers, and Related Methods, Kits, and Compositions. Justin Wilson and Stephen J. Lippard. Patent #8,729,286 B2. May 20, 2014. MIT #15010
  14. Zinc-Responsive Peptides, and Methods of Use Thereof. Robert J. Radford and Stephen J. Lippard. Patent #8,883,962. November 11, 2014. MIT #15316
  15. Functionalized Polymeric Nanoparticles as Vehicles for Targeted Delivery of Platinum Drugs. Shanta Dhar, Omid C. Farokhzad, Frank X. Gu, Nagesh Kolishetti, and Stephen J. Lippard. Patent #8,906,417 B2. December 9, 2014. MIT #13405J
  16. Platinum(IV) Complexes for Use in Dual Mode Pharmaceutical Therapy. Shanta Dhar, and Stephen J. Lippard. Patent #9,265,747. February 23, 2016. MIT #13271
  17. Anticancer Drug-Containing Plant Virus Particles. Nicole F. Steinmetz, Stephen J. Lippard, Anna Czapar, and Yaorong Zheng. Patent #10,624,975. April 21, 2020. MIT #17741J
  18. Compositions and Methods for Selectively Sequestering Metal Ions. Matthew D. Shoulders, Stephen J. Lippard, Elizabeth M. Nolan, Christopher E. R. Richardson and Lisa S. Cunden. Patent #10,946,361. March 16, 2021. MIT #19701

Pending patents:

  1. Soluble Nanoparticles as Delivery Systems for Prodrugs. Hongjie Dai, Rodney Feazell, and Stephen J. Lippard. May 6, 2008. MIT #12688J
  2. Polyvalent Oligonucleotide Gold Nanoparticle Conjugates as Delivery Vehicles for Platinum(IV) Warheads. Weston L. Daniel, Shanta Dhar, David A. Giljohann, Stephen J. Lippard, and Chad A. Mirkin. September 1, 2010. MIT #13912J
  3. Highly Potent Monofunctional Platinum(II) Anticancer Agents, cDACP (Acroplatin) and Cdpncp (Phenanthroplatin). Ga Young Park and Stephen J. Lippard. June 21, 2011. MIT #14702
  4. Particles for Multiple Agent Delivery. Omid C. Farokhzad, Nagesh Kolishetti, Shanta Dhar, Stephen J. Lippard, Robert S. Langer, Pedro M. Valencia. January 17, 2013. MIT #14034J
  5. Use of Chelators of Divalent Cations to Promote Nerve Regeneration. Larry I. Benowitz, Stephen J. Lippard, Paul Rosenberg, Yiqing Li, and Zhen Huang. June 26, 2014. MIT #15360J

Patent in progress:

  1. Monofunctional Platinum Anticancer Agents, Including Quinoplatin. Stephen J. Lippard and Ga Young Park. Not filed. MIT #14576

Expired patents:

  1. Platinum-Intercalative Complexes for the Treatment of Cancer. Bruce Bowler and Stephen J. Lippard. Patent #4,843,161. June 27, 1989. MIT #3891
  2. Catalytic Enantioselective Addition of Hydrocarbon Equivalents to Alpha, Beta-Unsaturated Carbonyl Compounds. Kwang-hyun Ahn, Stephen J. Lippard, and Gilberto M. Villacorta. Patent #4,962,214. October 9, 1990. MIT #4462
  3. Reductive Coupling of Carbon Compounds via Transition Metal Complexes. Patricia A. Bianconi, Stephen J. Lippard, Chebolu P. Rao, and Raymond N. Vrtis. Patent #5,026,884. June 25, 1991. MIT #4419
  4. Enantioselective Addition of Hydrocarbons to Alpha, Beta-Unsaturated Carbonyl Compounds. Kwang-hyun Ahn, Stephen J. Lippard, and Gilberto M. Villacorta. Patent #5,162,586. November 10, 1992. MIT #4462
  5. Nucleic Acids Encoding DNA Structure-Specific Recognition Protein and Uses Thereof. Steven J. Brown, Suzanne L. Bruhn, Brian A. Donahue, John M. Essigmann, Patti J. Kellett, Stephen J. Lippard, Pieter M. Pil, and Jeffrey H. Toney. Patent #5,359,047. October 25, 1994. MIT #4787
  6. Enantioselective Addition of Hydrocarbons to Alpha, Beta-Unsaturated Carbonyl Compounds. Kwang-hyun Ahn, Stephen J. Lippard, and Gilberto M. Villacorta. Patent #5,440,062. August 8, 1995. MIT #4462
  7. DNA Structure Specific Recognition Protein Complexes. Steven J. Brown, Suzanne L. Bruhn, Brian A. Donahue, John M. Essigmann, Patti J. Kellett, Stephen J. Lippard, Pieter M. Pil, and Jeffrey H. Toney. Patent #5,670,621. Sep- tember 23, 1997. MIT #6701
  8. Photo-Potentiation of Cisplatin Chemotherapy. Stefanie A. Kane and Stephen J. Lippard. Patent #6,030,783. February 29, 2000. MIT #6807
  9. Uses for DNA Structure-Specific Recognition Protein. Steven J. Brown, Suzanne L. Bruhn, Brian A. Donahue, John M. Essigmann, Patti J. Kellett, Stephen J. Lippard, Pieter M. Pil, and Jeffrey H. Toney. Patent #6,475,791. November 5, 2002. MIT #6701
  10. Coordination Complexes Having Tethered Therapeutic Agents and/or Targeting Moieties, and Methods of Making and Using the Same. Stephen J. Lippard, Carmen M. Barnes, Ariel Haskel, and Katie R. Barnes. Patent #7,138,520 B2. November 21, 2006. MIT #10066